当前位置： SCI文献检索 > DIABETES RESEARCH AND CLINICAL PRACTICE期刊下所有文献 > Geographical variation in the progression of type 2 diabetes in Peru: The CRONICAS Cohort Study.

Geographical variation in the progression of type 2 diabetes in Peru: The CRONICAS Cohort Study.

Abstract：

BACKGROUND:The study aims were to estimate the incidence and risk factors for T2D in four settings with different degree of urbanization and altitude in Peru. METHODS:Prospective cohort study conducted in urban, semi-urban, and rural areas in Peru. An age- and sex-stratified random sample of participants was taken from the most updated census. T2D was defined as fasting blood glucose ⩾7.0mmol/L or taking anti-diabetes medication. Exposures were divided into two groups: geographical variables (urbanization and altitude), and modifiable risk factors. Incidence, relative risks (RR), 95% confidence intervals (95%CI), and population attributable fractions (PAF) were estimated. RESULTS:Data from 3135 participants, 48.8% males, mean age 55.6years, was analyzed. Overall baseline prevalence of T2D was 7.1% (95%CI 6.2-8.0%). At follow-up, including 6207 person-years of follow-up, a total of 121 new T2D cases were accrued, equating to an incidence of 1.95 (95%CI 1.63-2.33) per 100 person-years. There was no urban to rural gradient in the T2D incidence; however, compared to sea level sites, participants living in high altitude had a higher incidence of diabetes (RR=1.58; 95%CI 1.01-2.48). Obesity had the highest attributable risk for developing T2D, although results varied by setting, ranging from 14% to 80% depending on urbanization and altitude. CONCLUSIONS:Our results suggest that the incidence of T2D was greater in high altitude sites. New cases of diabetes were largely attributed to obesity, but with substantial variation in the contribution of obesity depending on the environment. These findings can inform appropriate context-specific strategies to reduce the incidence of diabetes.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Bernabé-Ortiz A,Carrillo-Larco RM,Gilman RH,Miele CH,Checkley W,Wells JC,Smeeth L,Miranda JJ,CRONICAS Cohort Study Group.

doi

10.1016/j.diabres.2016.09.007

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

135-145

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(16)30598-8

journal_volume

121

pub_type

杂志文章,多中心研究

在线工具

Geographical variation in the progression of type 2 diabetes in Peru: The CRONICAS Cohort Study.