Abstract:
:The prevalence, age at diagnosis, clinical characteristics and treatment of young diabetics, younger than 40 years were determined on the basis of a cross-sectional study of medical records of 2 health districts in Pahang, Malaysia. There were only 20 insulin-dependent diabetics (IDDM), prevalence 0.07 per 1000 inhabitants. There were 84 non-insulin-dependent diabetics (NIDDM), prevalence 0.3 per 1000 inhabitants. Three of the NIDDM patients could have malnutrition-related diabetes. Many NIDDM patients were asymptomatic which is an important reason why many of them remain undetected in the community. Seventy-four percent of the patients below the age of 30 years at diagnosis had NIDDM, 56% of the patients below the age of 20 years at diagnosis also had NIDDM and 54% of the NIDDM patients had a strong family history of diabetes. Many NIDDM patients were misdiagnosed as IDDM, especially if they were underweight, leading to considerable overuse of insulin. This study confirms that IDDM is rare in Malaysia, as in other Asian countries. Most young diabetics have NIDDM and have a strong family history. This pattern of diabetes in the young is unlike that seen in the West.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Lim TOdoi
10.1016/0168-8227(91)90078-rsubject
Has Abstractpub_date
1991-07-01 00:00:00pages
201-7issue
3eissn
0168-8227issn
1872-8227pii
0168-8227(91)90078-Rjournal_volume
12pub_type
杂志文章abstract::Otsuka Long-Evans Tokushima Fatty (OLETF) rats are a new strain of spontaneous non-insulin-dependent diabetes mellitus (NIDDM) models. To evaluate the role of glucose transporters (GLUT) in the development of diabetes in this model, we examined the action of insulin on the translocation of GLUT4 and GLUT1 in isolated ...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/s0168-8227(97)00101-0
更新日期:1997-12-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is characterised by beta-cell failure in the setting of obesity-related insulin resistance. Progressive beta-cell dysfunction determines the course of the disease, regardless of the treatment used. There is mounting evidence that chronically elevated circulating levels of glucose and fa...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,评审
doi:10.1016/S0168-8227(11)70012-2
更新日期:2011-08-01 00:00:00
abstract:AIMS:To examine the relationship of non-high-density lipoprotein cholesterol (non-HDL-C) level with cardiovascular disease (CVD) risk in type 2 diabetes patients and the general population by conducting a meta-analysis. METHODS:We made a comprehensive literature search for relevant observational studies investigating ...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,meta分析
doi:10.1016/j.diabres.2018.11.002
更新日期:2019-01-01 00:00:00
abstract::Amputation has been known to be a rare adverse event of sodium glucose co-transporter-2 (SGLT2) inhibitors. It remains unclear whether the SGLT2 inhibitor as a class or specific categories of the SGLT2 inhibitors are linked with an increased risk of amputation. The objective of this meta-analysis was to investigate th...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,meta分析
doi:10.1016/j.diabres.2020.108136
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:The relation between diabetes mellitus (DM) and mortality among patients with acute myocardial infarction is still controversial. We evaluated the influence of DM on the in-hospital mortality of acute myocardial infarction (AMI) patients using data from the Tokai Acute Myocardial Infarction Study-II, a multi...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,多中心研究
doi:10.1016/j.diabres.2006.04.011
更新日期:2007-01-01 00:00:00
abstract::There is a growing body of evidence that the insulin-like growth factors (IGF-I and IGF-II) are dynamically involved in the regulation of glucose homeostasis, with one of their binding proteins, IGFBP-1, playing a counterregulatory role. The IGFs are structurally and functionally related to insulin and in the circulat...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,评审
doi:10.1016/0168-8227(94)90121-x
更新日期:1994-02-01 00:00:00
abstract::The aim of this study was to investigate the relationships between daily stress and glycaemic control in 54 people with Type 1 diabetes over 21 days. Measures included daily reports of stress (hassles), four-times-daily blood glucose measurements, and HbA1c levels. Time-series analyses revealed considerable variation ...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2004.04.001
更新日期:2004-12-01 00:00:00
abstract::This paper aims to underscore the importance of insulin intensification, while highlighting the clinical utility of modern premixes through intensification lessons, by utilising data from key clinical trials, and from the recently published large observational PRESENT Study. Insulin intensification is any change made ...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,评审
doi:10.1016/j.diabres.2008.06.010
更新日期:2008-09-01 00:00:00
abstract::Insulin antibodies (IAA) can be detected in the serum of the majority of newly diagnosed IDDM patients prior to insulin therapy. In first degree relatives of IDDM patients, IAA are associated with an increased risk of development of IDDM. However, the disease specificity of IAA, detected by radiobinding assays, has no...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/0168-8227(92)90006-d
更新日期:1992-11-01 00:00:00
abstract::The impact of hypertension, overall obesity and abdominal obesity, individually or collectively, on diabetes incidence over a period of 5 years in residents with different glucose levels is diverse, with abdominal obesity having an impact in both non-diabetic hyperglycaemia and normal groups. ...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2011.08.018
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To investigate factors related to diabetic retinopathy (DR). METHOD:Clinical data of 603 Chinese diabetic patients were analyzed retrospectively. On the basis of its severity, DR was graded as non-diabetic retinopathy (NDR), non proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2011.02.007
更新日期:2011-05-01 00:00:00
abstract:AIMS:Thiol/disulphide homeostasis plays a critical role in antioxidant defense, and detoxification in body. Although alteration of thiol/disulfide homeostasis had been shown in patients with diabetes, the thiol/disulfide balance in patients with type 2 diabetes and nephropathy is not yet known. METHODS:Twenty-six heal...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2019.01.022
更新日期:2019-02-01 00:00:00
abstract::A hypothesis that mitochondrial genome itself is the thrifty genome has been advanced, as both its mutation, or quality, and amount in the peripheral blood, or quantity, are found to have close relationship to diabetes mellitus, or more specifically insulin resistance. Mere presence of relationship, however, does not ...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,评审
doi:10.1016/s0168-8227(01)00336-9
更新日期:2001-12-01 00:00:00
abstract:AIMS:Diabetes therapies that provide durable glycaemic control for people with type 2 diabetes mellitus (T2DM) are needed. We present efficacy results of albiglutide, a glucagon-like peptide-1 receptor agonist, in people with T2DM over a 3-year period. METHODS:Five of the 8 HARMONY phase 3 trials, comparing albiglutid...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.diabres.2017.06.013
更新日期:2017-09-01 00:00:00
abstract:AIMS:To directly compare the effectiveness and safety between two distinct sodium-glucose co-transporter 2 (SGLT2) inhibitors, empagliflozin and dapagliflozin, as part of a quadruple oral antidiabetic agents (OADs) in patients with inadequately controlled type 2 diabetes (T2D). METHODS:This study was an open-labeled, ...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2019.04.008
更新日期:2019-05-01 00:00:00
abstract:AIM:Dyslipidaemia may be a risk factor for diabetic kidney disease. We examined prospectively association between the use of statins and development of renal dysfunction in type 2 diabetes. METHODS:A consecutive cohort of 5264 diabetic patient recruited between 1996 and 2005 underwent detailed assessments. Renal dysfu...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2010.02.006
更新日期:2010-06-01 00:00:00
abstract::This study compared the relative role of insulin resistance and beta-cell dysfunction (both assessed using the HOMA method) with glucose intolerance conditions in the progression to type 2 diabetes among a high risk group of subjects with fasting plasma glucose (FPG) 5.6-7.0 mmol/l in Kinmen, Taiwan. Data were collect...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/s0168-8227(02)00249-8
更新日期:2003-03-01 00:00:00
abstract:AIMS:Dementia and type 2 diabetes (T2D) are two major phenomena in older people. To compare anti-hyperglycemic therapy and diabetes-related comorbidities between elderly T2D patients with or without comorbid dementia. METHODS:215,932 type 2 diabetes patients aged ≥ 40 years (median [Q1;Q3]: 70.4 [61.2;77.7] years) fro...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,多中心研究
doi:10.1016/j.diabres.2015.10.026
更新日期:2016-02-01 00:00:00
abstract::The influence of xenogeneic islet cell surface antibodies (ICSA) on the hormonal secretion of non-B islet cells has not been completely elucidated. Accordingly, we investigated the influence of xenogeneic antiserum on glucagon release from A cells, as representative of non-B islet cells, together with other characteri...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/s0168-8227(87)80020-7
更新日期:1987-05-01 00:00:00
abstract::The aim of this study was to compare the effect of nasally administered glucagon in doses of 1 (A) and 2 mg (B), with 1 mg glucagon administered intramuscularly (C) in 12 C-peptide-negative IDDM patients. Spontaneous recovery (D) from insulin-induced hypoglycaemia in the same patients was used as reference. The mean a...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/0168-8227(92)90042-p
更新日期:1992-07-01 00:00:00
abstract::We retrospectively examined the frequency of bladder cancer in Japanese patients with type 2 diabetes in relation to use of pioglitazone. Among a total of 663 patients identified to be taking pioglitazone, 9 had bladder cancer (1.36%). Overall the hazard ratio of 1.75 [95% CI: 0.89-3.45] for pioglitazone for bladder c...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2012.11.013
更新日期:2013-02-01 00:00:00
abstract:AIMS:We evaluated whether glucose fluctuation (GF) causes vascular endothelial injury and affects glucometabolic factors during lengthy oral glucose tolerance test (OGTT). METHODS:We enrolled consecutive 116 patients with coronary artery disease (CAD) who were performed coronary angiography and 4-h OGTT. Blood samples...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2017.07.007
更新日期:2017-09-01 00:00:00
abstract::This retrospective study aimed to characterize comorbidities and associated with mortality among hospitalized adults with Covid-19 managed as perthe Saudi Ministry of Health protocol in a specialized tertiary hospital in Riyadh, Saudi Arabia. Medical records of 300 adult patients with PCR-confirmed SARS-CoV2 infection...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2020.108538
更新日期:2020-11-12 00:00:00
abstract:AIMS:To evaluate the impact of gestational diabetes mellitus (GDM) and maternal height on offspring birthweight. METHODS:This is an observational cohort study, encompassing 4 111 Finnish primiparous women from Vantaa city, Finland, with singleton deliveries between 2009 and 2015. Data were obtained from the Finnish Me...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2019.01.004
更新日期:2019-02-01 00:00:00
abstract:AIMS:To examine the impact of physical fitness (PF) on the association between fasting serum triglycerides (FTG) and diabetes risk and whether temporal changes in FTG predict diabetes risk in healthy middle-aged men. METHODS:FTG and PF (bicycle exercise test) were measured in 1962 men aged 40-59 years in 1972-1975 (Su...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2013.06.001
更新日期:2013-08-01 00:00:00
abstract::With the objective to determine the frequency of microalbuminuria, macroalbuminuria and the associated clinic and metabolic features among insulin dependent diabetes mellitus (IDDM) Brazilian patients attending at a general University Hospital, a total of 50 outpatients, aged 21.9 +/- 7 years with IDDM duration of 6.8...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/s0168-8227(97)01368-5
更新日期:1997-03-01 00:00:00
abstract:AIMS:To explore the real-world safety and effectiveness of gliclazide modified release (MR) in patients with type 2 diabetes mellitus (T2DM) fasting during Ramadan. METHODS:DIA-RAMADAN (NCT04132934) was a prospective, international, observational study conducted in nine countries. Patients >18 years of age with T2DM (...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2020.108154
更新日期:2020-05-01 00:00:00
abstract::Oral health information was included in 89.5% of diabetes education programs in states with high diabetes prevalence compared to 85.9% in low prevalence states (P = 0.22). Comparing the high to low diabetes prevalence states, there were significant differences in odds for responding "yes" to the topics "show patients ...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2010.09.020
更新日期:2010-12-01 00:00:00
abstract::Serum insulin 1 h post-glucose load is examined in this prospective study of 2971 Caucasoid subjects aged > 20 years in 1966 and followed to 1989. The serum insulin levels as a continuous variable show no significant linear association with coronary heart disease (CHD) deaths in either sex after accounting for age by ...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/0168-8227(94)90139-2
更新日期:1994-11-01 00:00:00
abstract:AIMS:To investigate whether increased risk of severe hypoglycaemia in early pregnancy is related to pregnancy-induced changes in renin-angiotensin system (RAS) activity in women with type 1 diabetes (T1DM). METHODS:Severe hypoglycaemic events the year preceding pregnancy were recorded retrospectively in 107 consecutiv...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2009.01.006
更新日期:2009-04-01 00:00:00