Abstract:
AIM:To evaluate the relationship of plasma endothelin-1 (ET-1) levels, a marker of endothelial dysfunction, and urinary albumin excretion in patients with type 2 diabetes mellitus (DM). METHODS:Cross-sectional study was conducted in 279 patients (132 males, mean age: 58.7+/-11.0 years, mean DM duration: 11.3+/-8.1 years). Urinary albumin excretion, ET-1, and insulin were measured. Insulin sensitivity was estimated by homeostasis model assessment (HOMA-ir) index. RESULTS:ET-1 was associated with urinary albumin excretion after controlling for age, gender, body mass index, blood pressure, HbA1c test, and total cholesterol (R=0.436; adjusted R(2)=0.190, P<0.01). Furthermore, there was a progressive increase in plasma ET-1 levels from patients with normoalbuminuria (n=187, 0.92+/-0.50pg/ml), microalbuminuria (n=68, 1.13+/-0.52pg/ml) to macroalbuminuria (n=24, 1.93+/-1.10pg/ml, P<0.01). CONCLUSION:There is an independent association of plasma ET-1 levels with urinary albumin excretion. In addition, plasma ET-1 levels started to increase in the normal values of urinary albumin excretion suggesting that in patients with type 2 DM endothelial dysfunction is already present, in urinary albumin excretion values considered normal.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Zanatta CM,Gerchman F,Burttet L,Nabinger G,Jacques-Silva MC,Canani LH,Gross JLdoi
10.1016/j.diabres.2007.12.024subject
Has Abstractpub_date
2008-05-01 00:00:00pages
299-304issue
2eissn
0168-8227issn
1872-8227pii
S0168-8227(08)00006-5journal_volume
80pub_type
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journal_title:Diabetes research and clinical practice
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doi:10.1016/0168-8227(95)01067-n
更新日期:1995-05-01 00:00:00
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journal_title:Diabetes research and clinical practice
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更新日期:2016-07-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:Diabetes research and clinical practice
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doi:10.1016/0168-8227(94)90050-7
更新日期:1994-01-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,评审
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更新日期:1996-06-01 00:00:00
abstract:BACKGROUND AND AIMS:The data regarding comparison of efficacy of metformin with glimepiride, newest Sulfonylurea, or with the use of both drugs in combination with insulin is rare in the literature. Therefore, we assessed the daily insulin dose, hypoglycemic events and body weight on achieving desirable glycemic contro...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2005.10.024
更新日期:2006-06-01 00:00:00
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journal_title:Diabetes research and clinical practice
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更新日期:2018-10-01 00:00:00
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journal_title:Diabetes research and clinical practice
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更新日期:2011-06-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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更新日期:1987-09-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/s0168-8227(02)00130-4
更新日期:2002-11-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,meta分析,评审
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更新日期:2020-01-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 临床试验,杂志文章
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更新日期:1996-10-01 00:00:00
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更新日期:2020-12-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2012.04.015
更新日期:2012-10-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2010.03.029
更新日期:2010-06-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2005.12.014
更新日期:2006-08-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/s0168-8227(87)80043-8
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,随机对照试验
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更新日期:2008-03-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-04-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2014.04.004
更新日期:2014-06-01 00:00:00
abstract::Optical measurement of skin auto-fluorescence (SAF), most likely emanating from accumulated advanced glycation end-products (AGEs), has been proposed for the noninvasive diagnosis of glucose intolerance in clinical settings. Here, we developed a novel imaging system with transmission geometry for SAF measurement and c...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2016.03.014
更新日期:2016-06-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2005.11.002
更新日期:2006-06-01 00:00:00
abstract::Four patients who exhibited the greatest decline in the estimated glomerular filtration rate [12.3-23.5 ml/min/1.73 m(2)/year] among 320 patients with type 2 diabetes and were followed for a median of 6.8 years had several clinical features in common, including marked albuminuria, microhematuria, retinopathy and poor ...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2013.01.031
更新日期:2013-05-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2020.108299
更新日期:2020-08-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
abstract::The aim of the present study was to evaluate the risk for vascular morbidity or death and retinopathy in relation to urinary albumin concentration. To that end, we performed a 5-year follow-up study of all type 2 diabetic patients attending the outpatient-clinic. A total of 444 (98.4%) out of 451 adult patients initia...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/0168-8227(96)01218-1
更新日期:1996-04-01 00:00:00
abstract:AIM:This study aimed to determine the prevalence of gestational diabetes mellitus (GDM) among women attending public health centers in Rwanda using the World Health Organization (WHO) 2013 diagnostic criteria. METHODS:A cross-sectional analysis was performed on 281 pregnant women attending antenatal care at urban and ...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2019.03.035
更新日期:2019-05-01 00:00:00
abstract::The effects of exercise on alterations in the amount of B-cell mass, insulin content and fibrous tissue present in the pancreas were examined for a diabetic state induced by a 70% pancreatectomy and a prediabetic state in Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a model for the spontaneous development of non-ins...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/s0168-8227(96)01357-5
更新日期:1997-02-01 00:00:00