Abstract：
:Insulin's indispensible nature is recognised by its inclusion in the World Health Organization's Essential Medicines List. Despite this insulin is still not available on an uninterrupted basis in many parts of the developing world. The International Insulin Foundation has conducted in-country assessments and based on these findings, the barriers to access to insulin were more to do with problems linked distribution, tendering and government policies than purely accessibility and affordability issues. Lack of insulin leads to poor outcomes for people with diabetes, but access to medicines alone cannot improve levels of health in resource poor settings. Aspects such as strong political will and local champions, data, trained healthcare workers and diabetes associations are just as necessary. Strengthening health systems and developing sustainable and locally owned solutions are vital to improve health and health care for people with diabetes and other chronic conditions in resource poor settings.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Beran D,Yudkin JSdoi
10.1016/j.diabres.2010.03.029subject
Has Abstractpub_date
2010-06-01 00:00:00pages
217-21issue
3eissn
0168-8227issn
1872-8227pii
S0168-8227(10)00173-7journal_volume
88pub_type
杂志文章abstract：:Diabetes mellitus is associated with increased frequency, severity and more rapid progression of cardiovascular diseases. Metabolic perturbations from hyperglycemia result in disturbed endothelium-dependent relaxation, activation of coagulation pathways, depressed fibrinolysis, and other abnormalities in vascular home...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/s0168-8227(99)00036-4
更新日期：1999-09-01 00:00:00
abstract：AIM:To investigate the relationship between nocturnal blood pressure and chronically elevated blood glucose to determine if these elevated blood glucose concentrations contribute to a non-dipping blood pressure, especially in high-risk groups such as Africans. METHODS:Nocturnal blood pressures and blood glucose levels...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2011.05.011
更新日期：2011-08-01 00:00:00
abstract：AIMS:Thiazide diuretics are recommended as first line antihypertensive treatment, but may contribute to new onset diabetes. We aimed to describe change in fasting glucose (FG) during prolonged thiazide treatment in an observational setting. METHODS:We conducted an observational, non-randomized, open label, follow-up s...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2014.04.004
更新日期：2014-06-01 00:00:00
abstract：:Glomerular hyperfiltration plays a pathogenic role in the early stages of diabetic nephropathy. Experimental studies in laboratory animals suggest that nitric oxide (NO) might be involved in the pathogenesis of glomerular hyperfiltration. We performed a cross-sectional study to determine the relationship between diabe...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,多中心研究
doi：10.1016/s0168-8227(01)00260-1
更新日期：2001-09-01 00:00:00
abstract：:Amputation has been known to be a rare adverse event of sodium glucose co-transporter-2 (SGLT2) inhibitors. It remains unclear whether the SGLT2 inhibitor as a class or specific categories of the SGLT2 inhibitors are linked with an increased risk of amputation. The objective of this meta-analysis was to investigate th...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,meta分析
doi：10.1016/j.diabres.2020.108136
更新日期：2020-05-01 00:00:00
abstract：:Corosolic acid (CRA) is a substance extracted from Lagerstroemia speciosa L. and has been reported to have biological activities in in vitro and experimental animal studies. In this study, 31 subjects were orally administered 10mg CRA or a placebo, on different occasions, in a capsule 5min before the 75-g oral glucose...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2006.01.010
更新日期：2006-08-01 00:00:00
abstract：AIMS:Diabetes and its complications have a significant economic impact on individuals and their families, health systems and national economies. METHODS:The direct health expenditure of diabetes was calculated relying on the following inputs: diagnosed and undiagnosed diabetes prevalence estimates, United Nations popu...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2020.108072
更新日期：2020-04-01 00:00:00
abstract：:We report a case of nephrotic syndrome complicating pregnancy in a woman with CSII-treated type 1 diabetes. This was associated with deteriorating glycaemic control which was successfully managed with continuous intravenous insulin for the two weeks before delivery. ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2011.04.002
更新日期：2011-07-01 00:00:00
abstract：:The In-R1-G9 cell line is one of the clones derived from the In-111-R1 hamster insulinoma cell line and produces glucagon. The secretory responses of In-R1-G9 cells were further examined to characterize the nature of the cells. Vincristine had no effect on glucagon secretion and colchicine enhanced glucagon secretion ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(88)80019-6
更新日期：1988-02-19 00:00:00
abstract：:Korean type 2 diabetics differ from Western diabetics in showing non-obese but centrally obese anthropometry and relatively more insulin secretory defects than insulin resistance. We assessed insulin secretion based on fasting serum C-peptide level and insulin resistance using the short insulin tolerance test (Kitt; r...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2007.01.067
更新日期：2007-09-01 00:00:00
abstract：:There are scant data from African populations on the association between beta-cell function and response to treatment with oral hypoglycaemic agents in Type 2 diabetes mellitus (T2DM). Fasting plasma C-peptide (FCP) and glucagon-stimulated C-peptide (GSCP) levels were measured in 116 Nigerians with T2DM at a universit...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2004.12.006
更新日期：2005-08-01 00:00:00
abstract：AIMS:To determine the relationships between cardiovascular autonomic neuropathy (CAN) and autonomic symptoms, clinical parameters and diabetic complications in type 2 diabetes (T2DM). METHODS:The results of autonomic symptoms, clinical parameters, diabetes complications and cardiovascular reflex (CVR) tests of 674 T2D...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2008.08.012
更新日期：2008-11-01 00:00:00
abstract：AIMS:To evaluate whether progressively higher fasting plasma glucose (FPG) is associated to thickening of the interventricular septum (IVS) among non-diabetic subjects with obesity. METHODOLOGY:We studied 227 consecutive non diabetic patients (155 women and 72 men, age range 18-72 years) with overweight or obesity (BM...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2020.108436
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:While the mechanisms leading to β-cell destruction and clinical onset of T1D are still unclear, the composition of the immune profile is probably important for the outcome of immune activity. The aim of this study was to investigate the composition and possible changes of the immunological profile, spontaneo...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2013.01.014
更新日期：2013-04-01 00:00:00
abstract：:The aim of the present study was to evaluate the risk for vascular morbidity or death and retinopathy in relation to urinary albumin concentration. To that end, we performed a 5-year follow-up study of all type 2 diabetic patients attending the outpatient-clinic. A total of 444 (98.4%) out of 451 adult patients initia...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(96)01218-1
更新日期：1996-04-01 00:00:00
abstract：:The recurrence rate of GDM among women in Japan who had GDM or one abnormal value on 75 g oral glucose tolerance test (OAV) during an initial pregnancy is unclear. We therefore sought to determine the recurrence rate and risk factors of recurrent GDM by evaluating 32 patients with GDM and 37 with OAV in their index pr...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2005.05.011
更新日期：2006-01-01 00:00:00
abstract：AIMS:Diabetes is a major risk factor for heart failure (HF). We examined whether baseline HbA1c level predicts HF incidence independent of other HF risk factors, including baseline cardiac structural and functional abnormalities. METHODS:In patients with type 2 diabetes, multivariable Cox regression models were constr...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2014.02.009
更新日期：2014-05-01 00:00:00
abstract：AIM:To assess the effect of metformin on cancer incidence in type 2 diabetes (T2DM), considering possible interactions with other glucose-lowering drugs and diabetes duration. METHODS:Study cohort included diabetes patients aged 20-84 on December 2009, still alive and resident in Reggio Emilia province as of December ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/j.diabres.2018.04.036
更新日期：2018-09-01 00:00:00
abstract：AIMS:We evaluated the use and annual cost of complementary and alternative medicine (CAM) compared to conventional medicine in type 2 diabetes mellitus (DM) in the Korean population. METHODS:We analyzed the database of 2752 DM patients obtained from the Korean National Diabetes Program (KNDP). The cost data of convent...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2011.03.031
更新日期：2011-07-01 00:00:00
abstract：AIMS:The objective of the present analysis was to evaluate and quantify the risk for gestational diabetes mellitus (GDM) according to maternal age. METHODS:Three electronic databases were searched for publications from inception to July 2018. Odds ratio (OR) and 95% confidence interval (95% CI) were calculated. A dose...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,meta分析
doi：10.1016/j.diabres.2020.108044
更新日期：2020-04-01 00:00:00
abstract：:Both elevated liver enzymes and a family history of diabetes mellitus (FHDM) are independent risk factors for type 2 diabetes. This study evaluates the epidemiological association between elevated liver enzymes and FHDM. Subjects included 3512 women workers without diabetes, hepatitis, a smoking habit, or a history of...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2007.10.032
更新日期：2008-03-01 00:00:00
abstract：:Glucose-induced insulin secretion from beta-cells is often impaired in diabetic condition and by exposure to diabetogenic pharmacological agents. In pancreatic beta-cells, intracellular glucose metabolism regulates exocytosis of insulin granules, according to metabolism-secretion coupling in which glucose-induced mito...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/j.diabres.2007.01.026
更新日期：2007-09-01 00:00:00
abstract：AIMS:Spain has been one of the worst affected countries by the COVID-19 pandemic. A very strict lockdown at home was imposed with a tough restriction of mobility. We aimed to evaluate the impact of this exceptional scenario on glucose profile of patients with T1D prone to hypoglycemia using standalone continuous glucos...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2020.108354
更新日期：2020-09-01 00:00:00
abstract：AIMS:To test whether the genetic variant CCR5Delta32 in the CC-chemokine receptor 5, which is known to lead to CCR5 deficiency, is associated with mortality in type 2 diabetes patients. METHODS:We examined the effect of presence or absence of the CCR5Delta32 on overall and cardiovascular mortality risk in the Zwolle O...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2009.08.013
更新日期：2009-11-01 00:00:00
abstract：:This systematic review with meta-analysis examined whether lifestyle modification (diet and/or exercise) is effective for glycemic control in adults with type 2 diabetes in Southeast Asia. Results showed that lifestyle modification is effective in the short term (3months), but not over the longer term (6months) in thi...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.diabres.2016.10.008
更新日期：2016-12-01 00:00:00
abstract：:Several models of blood glucose meters are available to diabetic patients. They all require several steps for their operation, which increases the potential for user error. A new meter (One Touch TM System, Lifescan Inc., a Johnson & Johnson Company, Mountain View, CA) was designed to minimise the operational steps an...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(89)90045-4
更新日期：1989-06-20 00:00:00
abstract：AIM:To perform a systematic literature review and network meta-analysis (NMA) of randomized controlled trials (RCTs) to estimate effect of SGLT2 inhibitors on fracture risk in patients with T2DM. METHODS:A systematic search was performed on PubMed/Medline and ClinicalTrials.gov from inception to May 2018 to identify R...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2018.10.019
更新日期：2018-12-01 00:00:00
abstract：:For an epidemiological study of childhood diabetes, application forms for medical benefits filed in Osaka Prefecture were collected and analyzed. A total of 465 patients with childhood diabetes under 18 yr of age were identified during the period between 1978 and 1988; 371 (175 boys and 196 girls) of them were classif...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(92)90145-h
更新日期：1992-12-01 00:00:00
abstract：:The aim of this multicentre study was to investigate the effect--in everyday life--of long term administration of acarbose on parameters of glycaemic control, daily insulin requirements, lipid parameters and tolerability in ambulant type 1 diabetic subjects insufficiently controlled with diet and insulin. Furthermore,...
journal_title：Diabetes research and clinical practice
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/s0168-8227(98)00070-9
更新日期：1998-08-01 00:00:00
abstract：OBJECTIVE:The aim of our study was to assess the association between the TLR4 Asp299Gly polymorphism and vascular complications in patients with type 2 diabetes. METHODS:We examined 1090 patients with T2DM and 716 healthy controls. All subjects were genotyped for the Asp299Gly polymorphism by polymerase chain reaction...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2016.04.002
更新日期：2016-06-01 00:00:00
