Abstract：
:Korean type 2 diabetics differ from Western diabetics in showing non-obese but centrally obese anthropometry and relatively more insulin secretory defects than insulin resistance. We assessed insulin secretion based on fasting serum C-peptide level and insulin resistance using the short insulin tolerance test (Kitt; rate constant for plasma glucose disappearance) in 1601 type 2 diabetic Korean patients (831 men and 770 women). Insulin secretory defects were catergorized as severe (C-peptide<1.10 ng/ml), moderate (C-peptide 1.10-1.69 ng/ml), and mild to non-secretory defect (C-peptide> or=1.70 ng/ml). Groups with a Kitt value of less than 2.5%/min were considered insulin-resistant, while those with a Kitt value > or =2.5%/min were considered insulin-sensitive. Overall, 42.5% of patients had a BMI>or =25.0 kg/m(2), and 70.2% had a BMI> or =23.0 kg/m(2); 45.2% (41.7% of men and 58.3% of women) were abdominally obese (waist> or =90 cm in men and 80 cm in women); mean fasting serum C-peptide level was 1.93+/-0.90 ng/ml, and the mean Kitt value was 2.03+/-0.96%/min. Accordingly, 13, 33, and 54% of patients showed a severe, moderate, and mild to non-secretory defect, respectively; 70.6% were insulin-resistant; and 29.4% were insulin-sensitive. Obese type 2 diabetes is recently increasing in Korea, indicating a shift from insulin secretory defects to insulin resistance.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Kim DJ,Song KE,Park JW,Cho HK,Lee KW,Huh KBdoi
10.1016/j.diabres.2007.01.067subject
Has Abstractpub_date
2007-09-01 00:00:00pages
S252-7eissn
0168-8227issn
1872-8227pii
S0168-8227(07)00232-Xjournal_volume
77 Suppl 1pub_type
杂志文章abstract：:Glomerular hyperfiltration plays a pathogenic role in the early stages of diabetic nephropathy. Experimental studies in laboratory animals suggest that nitric oxide (NO) might be involved in the pathogenesis of glomerular hyperfiltration. We performed a cross-sectional study to determine the relationship between diabe...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,多中心研究
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journal_title：Diabetes research and clinical practice
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更新日期：2007-09-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
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更新日期：2007-06-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：1994-11-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：2007-08-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
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更新日期：2018-05-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：2015-03-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：2014-10-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：2013-05-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2018.09.012
更新日期：2018-10-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2015-01-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2012.10.014
更新日期：2013-01-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2020.108216
更新日期：2020-06-01 00:00:00
abstract：:Fifty-nine women with recent gestational diabetes participated in a randomized controlled trial to assess the feasibility and efficacy of a pragmatic diabetes risk reduction intervention. Intervention participants achieved improvements in energy, total and saturated fats, and carbohydrate intake, but no change in phys...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.diabres.2014.09.035
更新日期：2014-12-01 00:00:00
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journal_title：Diabetes research and clinical practice
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更新日期：2020-01-01 00:00:00
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journal_title：Diabetes research and clinical practice
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更新日期：1985-10-01 00:00:00
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更新日期：1993-02-01 00:00:00
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更新日期：1992-03-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,随机对照试验
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更新日期：2010-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.diabres.2007.07.014
更新日期：2008-01-01 00:00:00
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journal_title：Diabetes research and clinical practice
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更新日期：2019-06-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2015-06-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2001-12-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
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更新日期：2018-03-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,多中心研究
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更新日期：2011-11-01 00:00:00
abstract：:The increasing proportions of older persons accounting for global populations, and the implications for increasing rates of chronic diseases such as type 2 diabetes mellitus, continue to be a cause of concern for clinicians. Considering that older persons are a very heterogeneous group of individuals, the management o...
journal_title：Diabetes research and clinical practice
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