Abstract：
AIMS:To develop a risk "engine" or calculator, integrating the risks of hyperglycemia, maternal BMI and other basic demographic data commonly available at the time of the pregnancy oral glucose tolerance test (OGTT), to predict an individual's absolute risk of specific adverse pregnancy outcomes. METHODS:Data from the Brisbane HAPO cohort was analysed using logistic regression to determine the relationship between four clinical outcomes (primary CS, birth injury, large-for-gestational age, excess neonatal adiposity) with different combinations of OGTT results and maternal demographics (age, height, BMI, parity). Existing sets of international GDM diagnostic criteria were also applied to the cohort. RESULTS:191 (15.3%) women were diagnosed as GDM by one or more existing criteria. All international criteria performed poorly compared to risk models utilising OGTT results only, or OGTT results in combination with maternal demographics. CONCLUSIONS:The risk engine's empirical performance on receiver - operator curve analysis was superior to the existing GDM diagnostic criteria tested. This concept shows promise for use in clinical practice, but further development is required.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
McIntyre HD,Gibbons KS,Lowe J,Oats JJNdoi
10.1016/j.diabres.2018.02.036subject
Has Abstractpub_date
2018-05-01 00:00:00pages
331-338eissn
0168-8227issn
1872-8227pii
S0168-8227(18)30272-9journal_volume
139pub_type
杂志文章,评审abstract：AIM:To assess efficacy/safety of initial linagliptin/metformin single-pill combination (SPC) therapies versus individual drug components over 24weeks in treatment-naïve Asian patients with type 2 diabetes mellitus and insufficient glycemic control. METHODS:Patients (initial glycated hemoglobin [HbA1c] ⩾7.5% to <11.0% ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.diabres.2016.11.026
更新日期：2017-02-01 00:00:00
abstract：:The effect of short-term insulin treatment with a long-acting insulin preparation, Ultratard HM (U-HM) was investigated in eight non-insulin-dependent diabetes mellitus (NIDDM) patients whose previous glycemic control using diet was judged unsatisfactory. The treatment consisted of one daily pre-breakfast injection of...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(87)80058-x
更新日期：1987-11-01 00:00:00
abstract：:We present a boy with mild hyperglycemia detected during an upper respiratory infection. Novel splicing mutation in the intron 1 of the GCK gene (c.45+1G>A) was detected, and was subsequently confirmed in his father. This is the first case of genetically confirmed Macedonian family with MODY. ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2017.04.001
更新日期：2017-08-01 00:00:00
abstract：:Epidemiological studies on diabetes mellitus revealed that the number of patients with diabetes mellitus is gradually increasing in Japan along with development of car society and westernization of food intake. Since prevalence of diabetes mellitus increases with aging, proportion of individuals with diabetes mellitus...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2007.01.070
更新日期：2007-09-01 00:00:00
abstract：:United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) was established in 1949 and has delivered health care services for over 65 years. The epidemiological transition in disease burden is changing the context in which UNRWA's health programme operates and poses new challenges that requ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/j.diabres.2015.01.035
更新日期：2015-04-01 00:00:00
abstract：:To investigate the evolution and significance of Q waves in type 2 diabetes, we studied 36 patients of mean (+/-S.D.) age 69.9+/-7.1 years from the longitudinal observational Fremantle Diabetes Study (FDS). All had (i) neither history/symptoms of coronary heart disease (CHD) nor pathological Q waves at FDS recruitment...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2008.06.016
更新日期：2008-10-01 00:00:00
abstract：AIMS:Media calcification is a predictor of cardiovascular mortality in type 2 diabetes mellitus (T2DM). Undercarboxylation of some vitamin K-dependent proteins, due to genetic polymorphisms of VKORC1, can lead to calcification. We examined a potential association between VKORC1 -1639 G>A polymorphism and T2DM and, also...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2011.06.021
更新日期：2011-11-01 00:00:00
abstract：AIM:To explore the association of Ramadan fasting with symptoms of depression, anxiety, and stress in people with diabetes. METHODS:This observational study was conducted at Baqai Institute of Diabetology and Endocrinology between May-July 2017. Informed consent was taken from each study participant. Demographic and b...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2020.108545
更新日期：2020-11-21 00:00:00
abstract：AIMS:The epidemiology for diabetic retinopathy (DR) has been well described in the western population. Countries in Sub-Saharan Africa have attempted to identify the prevalence of diabetic eye disease, however, there still remains a degree of paucity across the continent due to inadequacy in health system organisations...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2019.04.024
更新日期：2019-06-01 00:00:00
abstract：AIMS:Non-alcohol fatty liver disease (NAFLD) is a strong risk factor for insulin resistance and type 2 diabetes. The prevalence of NAFLD varies across populations of different ethnic backgrounds but the prevalence in Middle Eastern populations, which are at high risk of type 2 diabetes, is largely unknown. Using fatty ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2015.07.011
更新日期：2015-10-01 00:00:00
abstract：:The effect of a decoction of fig leaves (Ficus carica), as a supplement to breakfast, on diabetes control was studied in insulin-dependent diabetes mellitus (IDDM) patients (six men, four women, age 22-38 years, body mass index (BMI): 20.8 +/- 3.0 kg/m2, HbA1c 7.6 +/- 0.9% with a mean duration of diabetes of 9 +/- 6.3...
journal_title：Diabetes research and clinical practice
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0168-8227(97)00112-5
更新日期：1998-01-01 00:00:00
abstract：:There is a growing body of evidence that the insulin-like growth factors (IGF-I and IGF-II) are dynamically involved in the regulation of glucose homeostasis, with one of their binding proteins, IGFBP-1, playing a counterregulatory role. The IGFs are structurally and functionally related to insulin and in the circulat...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/0168-8227(94)90121-x
更新日期：1994-02-01 00:00:00
abstract：:Apolipoprotein C III (apo C III) plays a central role in regulating plasma metabolism of triglyceride-rich lipoprotein (TRL). The G3238C allele (Sst I) in the 3'-untranslated region has been found to be associated with raised apo C III levels and hypertriglyceridemia (HTG). Some studies suggest that apo C III and the ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2004.02.020
更新日期：2004-10-01 00:00:00
abstract：BACKGROUND:The aim of this study was to compare the effect of glycaemic control on oxidative stress and biochemical markers of endothelial activation in type 1 diabetic children. METHODS:Serum total cholesterol, HDL cholesterol, VLDL cholesterol, apolipoprotein A1, apolipoprotein B, HbA(1c), MDA, VEGF, NO, ICAM levels...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2006.01.001
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND:While CKD is a common finding in patients with type 2 diabetes, the clinical response to its identification is often problematic. This study aims to determine the frequency of albuminuria in patients with type 2 diabetes in the primary care setting and examine the factors which influence its management. MET...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2007.10.024
更新日期：2008-04-01 00:00:00
abstract：AIMS:Studies have shown that diabetes mellitus disproportionately afflicts persons of low socioeconomic status and that the burden of disease is greatest among the disadvantaged. However, our understanding of educational differences in the control of diabetes and its impact on survival is limited. This study investigat...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2014.12.013
更新日期：2015-03-01 00:00:00
abstract：:Despite numerous publications according to which insulin promotes atherosclerosis, there are many observations in the last fifteen years suggesting that insulin has antiatherogenic properties. Insulin has vasodilatory, antithrombotic and anti-inflammatory effects. A good glycemic control contributes to the maximum eff...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/S0168-8227(11)70024-9
更新日期：2011-08-01 00:00:00
abstract：:This review focuses on the burgeoning use of web-based systems allowing patient-initiated glucometer uploads to facilitate provider treatment intensification. Studies in type 1 diabetes tended to show equivalent HbA1c improvements in both intervention and control groups without statistically significant difference. In...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/j.diabres.2008.09.055
更新日期：2009-01-01 00:00:00
abstract：AIMS:Insulin resistance (IR) detection is challenging and no test is currently used in clinical practice. We developed salivary biomarkers that could be used for IR detection. METHODS:We collected saliva from 186 healthy and 276 pre-diabetic participants, divided them into high and low IR groups based on a HOMA cutoff...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2017.07.008
更新日期：2017-10-01 00:00:00
abstract：:We simultaneously determined 3H-thymidine incorporation, DNA content, and insulin biosynthesis in adult and fetal rat pancreatic islets. 3H-thymidine incorporation was measured after tissue solubilization. DNA was measured fluorometrically. Insulin biosynthesis was determined through 3H-leucine incorporation after imm...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(88)80053-6
更新日期：1988-07-13 00:00:00
abstract：:The increasing proportions of older persons accounting for global populations, and the implications for increasing rates of chronic diseases such as type 2 diabetes mellitus, continue to be a cause of concern for clinicians. Considering that older persons are a very heterogeneous group of individuals, the management o...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/S0168-8227(09)70007-5
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:The polymorphism 385 C/A of FAAH has been associated with overweight and obesity. The aim of our study was to investigate the relationship of polymorphism (cDNA 385 C-->A) of FAAH gene on obesity parameters in patients with diabetes mellitus type 2. DESIGN:A population of 70 patients with diabetes mellitus ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2009.12.019
更新日期：2010-04-01 00:00:00
abstract：:Amputation has been known to be a rare adverse event of sodium glucose co-transporter-2 (SGLT2) inhibitors. It remains unclear whether the SGLT2 inhibitor as a class or specific categories of the SGLT2 inhibitors are linked with an increased risk of amputation. The objective of this meta-analysis was to investigate th...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,meta分析
doi：10.1016/j.diabres.2020.108136
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:Increasing studies have focused on the relationship between soy intake and type 2 diabetes mellitus risk, but the results are inconsistent. We conduct a meta-analysis to evaluate the relationship. METHODS:The databases of PubMed, Web of Science and Embase were searched up to Dec 2016. A random-effect model ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.diabres.2018.01.010
更新日期：2018-03-01 00:00:00
abstract：:A low-carbohydrate/high-fat evening meal impaired the glucose tolerance of healthy subjects to almost the same extent as the impairment caused by overnight fasting. This suggests that the decreased component (carbohydrate) is more relevant than the increased component (fat) to the impairment of glucose tolerance by a ...
journal_title：Diabetes research and clinical practice
pub_type： 信件
doi：10.1016/s0168-8227(01)00291-1
更新日期：2002-01-01 00:00:00
abstract：:Methylglyoxal and other alpha-oxoaldehydes are formed from glycolytic intermediates and may be involved in the development of diabetic microangiopathy. Glyoxalase I and glyoxalase II metabolise methylglyoxal to D-lactic acid, via the intermediate S-D-lactoylglutathione. The activities of the glyoxalase enzymes and the...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(89)90101-0
更新日期：1989-08-01 00:00:00
abstract：AIMS:We examined whether 0.9 mg/day liraglutide plus basal insulin (Lira-basal) is superior to basal-bolus insulin therapy (BBIT) for type 2 diabetes (T2DM) without severe insulin deficiency as determined by glucagon stimulation. METHODS:Fifty patients receiving BBIT were enrolled in this 24-week, prospective, randomi...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.diabres.2018.03.032
更新日期：2018-06-01 00:00:00
abstract：AIMS:The Adherence to Refills and Medications Scale (ARMS) has been associated with objective measures of adherence and may address limitations of existing self-report measures of diabetes medication adherence. We modified the ARMS to specify adherence to diabetes medicines (ARMS-D), examined its psychometric propertie...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2013.09.010
更新日期：2013-11-01 00:00:00
abstract：AIMS:Infrared thermal imaging (IR) is not yet routinely implemented for early detection of diabetic foot ulcers (DFU), despite proven clinical effectiveness. Low-cost, smartphone-based IR-cameras are now available and may lower the threshold for implementation, but the quality of these cameras is unknown. We aim to val...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2019.01.032
更新日期：2019-03-01 00:00:00
abstract：:To evaluate the effect of pioglitazone on insulin resistance in non-insulin-dependent diabetes mellitus (NIDDM) patients, a double-blind placebo-controlled trial was carried out with 30 NIDDM patients. Twenty-one subjects, three on diet alone and 18 on sulfonylurea (SU), orally received 30 mg pioglitazone once daily f...
journal_title：Diabetes research and clinical practice
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0168-8227(98)00056-4
更新日期：1998-07-01 00:00:00
