Association of VKORC1 -1639 G>A polymorphism with carotid intima-media thickness in type 2 diabetes mellitus.

Abstract:

AIMS:Media calcification is a predictor of cardiovascular mortality in type 2 diabetes mellitus (T2DM). Undercarboxylation of some vitamin K-dependent proteins, due to genetic polymorphisms of VKORC1, can lead to calcification. We examined a potential association between VKORC1 -1639 G>A polymorphism and T2DM and, also, the association of this polymorphism with carotid intima-media thickness (cIMT). METHODS:VKORC1 -1639 G>A polymorphism was determined in 299 T2DM patients and 328 controls of Caucasian origin using PCR-RFLP. cIMT was measured in a subgroup of 118 T2DM patients. RESULTS:The frequency of VKORC1 genotypes between diabetic and nondiabetic subjects differed significantly (p=0.01). VKORC1 genotype was associated with T2DM in an adjusted model (OR 1.36, p=0.009). A statistically significant difference was observed in the maximum value of cIMT among different genotypes. VKORC1 -1639 G>A polymorphism was an independent predictor of cIMT (p=0.029) after adjusting for established risk factors. CONCLUSIONS:The association between VKORC1 -1639 G>A polymorphism and risk of T2DM could be due to the higher prevalence of calcification in T2DM patients. This is supported by the independent association between VKORC1 -1639 G>A polymorphism and maximum cIMT in T2DM patients which is likely due to atherosclerosis characterized by increased calcification.

authors

Tavridou A,Petridis I,Vasileiadis M,Ragia G,Heliopoulos I,Vargemezis V,Manolopoulos VG

doi

10.1016/j.diabres.2011.06.021

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

236-41

issue

2

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(11)00343-3

journal_volume

94

pub_type

杂志文章
  • Salivary extracellular RNA biomarkers for insulin resistance detection in hispanics.

    abstract:AIMS:Insulin resistance (IR) detection is challenging and no test is currently used in clinical practice. We developed salivary biomarkers that could be used for IR detection. METHODS:We collected saliva from 186 healthy and 276 pre-diabetic participants, divided them into high and low IR groups based on a HOMA cutoff...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2017.07.008

    authors: Zhang Y,Sun J,Li F,Grogan TR,Vergara JL,Luan Q,Park MS,Chia D,Elashoff D,Joshipura KJ,Wong DTW

    更新日期:2017-10-01 00:00:00

  • Lipid peroxidation in type 2 normolipidemic diabetic patients.

    abstract::Vascular complications, as a consequence of atherosclerosis, are the main causes of morbidity and mortality in diabetes. Low density lipoprotein (LDL) oxidation is accepted as a relevant pathogenic mechanism in atherogenesis. The aim of this work was to study the relationship between lipid peroxidation (LPO) and metab...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/s0168-8227(97)00032-6

    authors: Freitas JP,Filipe PM,Rodrigo FG

    更新日期:1997-05-01 00:00:00

  • Beta cell function and response to treatment in Nigerians with Type 2 diabetes mellitus.

    abstract::There are scant data from African populations on the association between beta-cell function and response to treatment with oral hypoglycaemic agents in Type 2 diabetes mellitus (T2DM). Fasting plasma C-peptide (FCP) and glucagon-stimulated C-peptide (GSCP) levels were measured in 116 Nigerians with T2DM at a universit...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2004.12.006

    authors: Oli JM,Adeyemo AA,Okafor GO,Ofoegbu EN,Onyenekwe B,Chukwuka CJ,Chen G,Chen Y,Doumatey AP,Aje TO,Rotimi CN

    更新日期:2005-08-01 00:00:00

  • The effect of mosapride citrate on constipation in patients with diabetes.

    abstract:OBJECTIVE:Constipation is one of the most common gastrointestinal complications suspected to degrade the quality of life in diabetic patients. Mosapride citrate is a novel selective 5-HT4 receptor agonist, which enhances gastric emptying and motility in the upper gastrointestinal tract facilitating acetylcholine releas...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2009.09.024

    authors: Ueno N,Inui A,Satoh Y

    更新日期:2010-01-01 00:00:00

  • High prevalence of COVID-19-associated diabetic ketoacidosis in UK secondary care.

    abstract::We aim to describe the prevalence of diabetic ketoacidosis (DKA) in individuals admitted to a single centre with COVID-19. We identified 218 individuals hospitalised with COVID-19, of these four fulfilled criteria for DKA (4/218, 1.8%). We conclude DKA is common and severe in individuals hospitalised with COVID-19. ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2020.108291

    authors: Goldman N,Fink D,Cai J,Lee YN,Davies Z

    更新日期:2020-08-01 00:00:00

  • Oral health content in diabetes self-management education programs.

    abstract::Oral health information was included in 89.5% of diabetes education programs in states with high diabetes prevalence compared to 85.9% in low prevalence states (P = 0.22). Comparing the high to low diabetes prevalence states, there were significant differences in odds for responding "yes" to the topics "show patients ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2010.09.020

    authors: Yuen HK,Marlow NM,Mahoney S,Slate E,Jenkins C,London S

    更新日期:2010-12-01 00:00:00

  • Alteration in fasting glucose after prolonged treatment with a thiazide diuretic.

    abstract:AIMS:Thiazide diuretics are recommended as first line antihypertensive treatment, but may contribute to new onset diabetes. We aimed to describe change in fasting glucose (FG) during prolonged thiazide treatment in an observational setting. METHODS:We conducted an observational, non-randomized, open label, follow-up s...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2014.04.004

    authors: Karnes JH,Gong Y,Arwood MJ,Gums JG,Hall KL,Limacher MC,Johnson JA,Cooper-DeHoff RM

    更新日期:2014-06-01 00:00:00

  • Does working memory training improve dietary self-care in type 2 diabetes mellitus? Results of a double blind randomised controlled trial.

    abstract:AIMS:Controlling food intake despite adequate knowledge remains a struggle for many people with type 2 diabetes. The present study investigated whether working memory training can reduce food intake and improve glycaemic control. It also examined training effects on cognition, food cravings, and dietary self-efficacy a...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.diabres.2018.07.005

    authors: Whitelock V,Nouwen A,Houben K,van den Akker O,Rosenthal M,Higgs S

    更新日期:2018-09-01 00:00:00

  • Associations between barriers to self-care and diabetes complications among patients with type 2 diabetes.

    abstract:AIMS:To determine which barriers to care are associated with type 2 diabetes complications in an area in rural East England. METHODS:3649 individuals with type 2 diabetes from 62 general practices were contacted via postal invitation which included a 33 item Barriers-to-Diabetes-Care Survey. Barriers were grouped into...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2018.04.031

    authors: Sina M,Graffy J,Simmons D

    更新日期:2018-07-01 00:00:00

  • Role of vascular reactive oxygen species in development of vascular abnormalities in diabetes.

    abstract::Macrovascular and microvascular diseases are currently the principal causes of morbidity and mortality in patients with diabetes. Oxidative stress has been postulated to be a major contributor to the pathogenesis of these events. There is considerable evidence that many biochemical pathways adversely affected by hyper...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,评审

    doi:10.1016/j.diabres.2007.01.036

    authors: Son SM

    更新日期:2007-09-01 00:00:00

  • Chronic calcific pancreatitis of the tropics (CCPT): spectrum and correlates of exocrine and endocrine pancreatic dysfunction.

    abstract::The exocrine and endocrine pathophysiology of chronic calcific pancreatitis of the tropics (CCPT) remains elusive. The objective of this study was to evaluate the spectrum and correlates of the exocrine and endocrine pancreatic dysfunction in CCPT. Thirty-seven consecutive patients with a clinico-radiological diagnosi...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/0168-8227(94)01021-q

    authors: Sidhu SS,Shah P,Prasanna BM,Srikanta SS,Tandon RK

    更新日期:1995-02-01 00:00:00

  • Effect of ischemia on peripheral nerve function in diabetes mellitus.

    abstract::In Japan, diabetic patients are known to be able to sit on the floor for a prolonged time because of mildness or absence of ischemic paresthesia. In order to investigate this resistance to ischemia quantitatively, the mixed nerve function of the median nerve was studied during 30 min of ischemia using surface electrod...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/s0168-8227(86)80004-3

    authors: Kuriya N,Mori M,Miyake S,Takamori M,Nagataki S

    更新日期:1986-09-01 00:00:00

  • Pakistan National Diabetes Survey: prevalence of glucose intolerance and associated factors in Baluchistan province.

    abstract::The prevalence of diabetes mellitus (DM) and impaired glucose tolerance (IGT) and their relationship to age and obesity was estimated in a population-based survey in urban and rural areas in Baluchistan province, Pakistan. Cluster sampling of 834 adults (260 men, 574 women) in the urban and 570 adults (175 men, 395 wo...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/s0168-8227(99)00017-0

    authors: Shera AS,Rafique G,Khawaja IA,Baqai S,King H

    更新日期:1999-04-01 00:00:00

  • Decreased A20 mRNA and protein expression in peripheral blood mononuclear cells in patients with type 2 diabetes and latent autoimmune diabetes in adults.

    abstract:AIMS:A20 is a negative regulator of nuclear factor kappa B activation and the central gatekeeper in inflammation and immunity. While its role in type 1 diabetes has been widely studied, its expression level in immune cells from type 2 diabetes (T2D) and latent autoimmune diabetes in adult (LADA) patients remains unclea...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2014.09.014

    authors: Cheng L,Zhang D,Jiang Y,Deng W,Wu Q,Jiang X,Chen B

    更新日期:2014-12-01 00:00:00

  • Metabolic response 4 years after gastric bypass in a complete cohort with type 2 diabetes mellitus.

    abstract:AIMS:To evaluate the long-term remission rates of type 2 diabetes mellitus and associated comorbidities after gastric bypass surgery in a complete cohort, in a real-life clinic setting. METHODS:A retrospective study of all consecutive patients with type 2 diabetes mellitus who underwent gastric bypass at a Veterans Af...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2017.11.022

    authors: Carranza-Leon BG,Puzziferri N,Adams-Huet B,Jabbour I,Lingvay I

    更新日期:2018-03-01 00:00:00

  • Fear, guilt feelings and misconceptions: barriers to effective insulin treatment in type 2 diabetes.

    abstract::Diabetes self management education, the process of teaching individuals to manage their diabetes, has been considered the cornerstone of the clinical management of individuals with diabetes since the work of the Joslin Diabetes Center. The goals of self-management education are to optimize metabolic control, prevent a...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,评审

    doi:10.1016/S0168-8227(11)70021-3

    authors: Benroubi M

    更新日期:2011-08-01 00:00:00

  • High rate of hypoglycemia in 6770 type 2 diabetes patients with comorbid dementia: A multicenter cohort study on 215,932 patients from the German/Austrian diabetes registry.

    abstract:AIMS:Dementia and type 2 diabetes (T2D) are two major phenomena in older people. To compare anti-hyperglycemic therapy and diabetes-related comorbidities between elderly T2D patients with or without comorbid dementia. METHODS:215,932 type 2 diabetes patients aged ≥ 40 years (median [Q1;Q3]: 70.4 [61.2;77.7] years) fro...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.diabres.2015.10.026

    authors: Prinz N,Stingl J,Dapp A,Denkinger MD,Fasching P,Jehle PM,Merger S,Mühldorfer S,Pieper U,Schuler A,Zeyfang A,Holl RW,DPV initiative.

    更新日期:2016-02-01 00:00:00

  • Effect of corosolic acid on postchallenge plasma glucose levels.

    abstract::Corosolic acid (CRA) is a substance extracted from Lagerstroemia speciosa L. and has been reported to have biological activities in in vitro and experimental animal studies. In this study, 31 subjects were orally administered 10mg CRA or a placebo, on different occasions, in a capsule 5min before the 75-g oral glucose...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2006.01.010

    authors: Fukushima M,Matsuyama F,Ueda N,Egawa K,Takemoto J,Kajimoto Y,Yonaha N,Miura T,Kaneko T,Nishi Y,Mitsui R,Fujita Y,Yamada Y,Seino Y

    更新日期:2006-08-01 00:00:00

  • Education, glucose control, and mortality risks among U.S. older adults with diabetes.

    abstract:AIMS:Studies have shown that diabetes mellitus disproportionately afflicts persons of low socioeconomic status and that the burden of disease is greatest among the disadvantaged. However, our understanding of educational differences in the control of diabetes and its impact on survival is limited. This study investigat...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2014.12.013

    authors: Dupre ME,Silberberg M,Willis JM,Feinglos MN

    更新日期:2015-03-01 00:00:00

  • Five fold increase of insulin concentration delays the absorption of subcutaneously injected human insulin suspensions in pigs.

    abstract::Human NPH U100 (100 IU/ml), given once daily, is often absorbed too fast to cover the basal insulin demand throughout 24 h. The aim of the present study was to examine whether the absorption of human insulin suspensions would be delayed by increasing the insulin concentration from U100 to U500. In each experiment 10 I...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/s0168-8227(00)00196-0

    authors: Jørgensen KH,Hansen AK,Buschard K

    更新日期:2000-12-01 00:00:00

  • Diabetes care in refugee camps: the experience of UNRWA.

    abstract::United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) was established in 1949 and has delivered health care services for over 65 years. The epidemiological transition in disease burden is changing the context in which UNRWA's health programme operates and poses new challenges that requ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,评审

    doi:10.1016/j.diabres.2015.01.035

    authors: Shahin Y,Kapur A,Seita A

    更新日期:2015-04-01 00:00:00

  • Premature loss of muscle mass and function in type 2 diabetes.

    abstract:INTRODUCTION:Muscle mass and function are among the most relevant factors that contribute to an optimal quality of life, and are strong predictors of mortality in the elderly. Loss of lean tissues and deterioration of muscle function have been described as one of the many complications of type 2 diabetes mellitus (DM2)...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2016.04.011

    authors: Guerrero N,Bunout D,Hirsch S,Barrera G,Leiva L,Henríquez S,De la Maza MP

    更新日期:2016-07-01 00:00:00

  • Insulin inhibits glucagon-induced glycogenolysis normally in perivenous hepatocytes of Wistar fatty rats.

    abstract::Wistar fatty (WF) rats are obese, hyperinsulinemic and hyperglycemic, and thus a model of type 2 diabetes mellitus. Since we have found that insulin specifically inhibits glucagon-induced glycogenolysis in perivenous hepatocytes (PVH) from normal rats, we examined the inhibitory effect of insulin on glucagon-induced g...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2004.12.008

    authors: Ikezawa Y,Yamatani K,Ohnuma H,Daimon M,Manaka H,Sasaki H

    更新日期:2005-08-01 00:00:00

  • Clinical characteristics of Korean type 2 diabetic patients in 2005.

    abstract::Korean type 2 diabetics differ from Western diabetics in showing non-obese but centrally obese anthropometry and relatively more insulin secretory defects than insulin resistance. We assessed insulin secretion based on fasting serum C-peptide level and insulin resistance using the short insulin tolerance test (Kitt; r...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2007.01.067

    authors: Kim DJ,Song KE,Park JW,Cho HK,Lee KW,Huh KB

    更新日期:2007-09-01 00:00:00

  • Fibre-enriched buckwheat pasta modifies blood glucose response compared to corn pasta in individuals with type 1 diabetes and celiac disease: Acute randomized controlled trial.

    abstract:AIM:People with type 1 diabetes and celiac disease (T1D&CD) have high blood glucose variability. Processed gluten-free foods have shown to induce a worse metabolic profile whereas naturally gluten-free foods may represent healthier options. On the other hand, dietary fibre has shown to reduce postprandial glycemic excu...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2019.02.013

    authors: Vetrani C,Bozzetto L,Giorgini M,Cavagnuolo L,Di Mattia E,Cipriano P,Mangione A,Todisco A,Inghilterra G,Giacco A,Annuzzi G,Rivellese AA

    更新日期:2019-03-01 00:00:00

  • Vaspin and its correlation with insulin sensitivity indices in obese children.

    abstract:AIM:The aim of this study was to assess the vaspin and adiponectin concentrations on markers of insulin sensitivity and obesity in pubertal obese children and adolescents. MATERIAL AND METHODS:Plasma vaspin and adiponectin level and its relationships with body mass index standard deviation score (BMI-SDS), insulin sen...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2009.03.008

    authors: Suleymanoglu S,Tascilar E,Pirgon O,Tapan S,Meral C,Abaci A

    更新日期:2009-06-01 00:00:00

  • Predictors and consequences of weight retention in the early and late postpartum period in women with gestational diabetes.

    abstract:AIMS:To assist preventive strategies, we investigated the predictors and consequences of postpartum weight retention (PPWR) in the early and late postpartum period in women with gestational diabetes (GDM). METHODS:862 women with GDM between 2011 and 2019 were prospectively included. We investigated PPWR at 6-8 weeks (...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2020.108238

    authors: Quansah DY,Gross J,Gilbert L,Arhab A,Horsch A,Puder JJ

    更新日期:2020-07-01 00:00:00

  • Sulfonylurea and fracture risk in patients with type 2 diabetes mellitus: A meta-analysis.

    abstract:AIMS:This meta-analysis was conducted to investigate the fracture risk among patients with T2DM treated with sulfonylurea. METHODS:The PubMed and other databases were searched for eligible studies. Both randomized controlled trials and observational studies that compared the fracture risk of sulfonylurea to other hypo...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.diabres.2019.107990

    authors: Zhang Z,Cao Y,Tao Y,E M,Tang J,Liu Y,Li F

    更新日期:2020-01-01 00:00:00

  • Effect of a new lente insulin on diabetics.

    abstract::Thirty diabetics who had been receiving ordinary insulin were switched to S-lente insulin, a new mixture of four parts semilente and six parts ultralente insulin. Eight times a day, we measured the glucose, insulin, and C-peptide (CPR) in their blood. Those with more than 250 mg/dl postprandial glucose were designated...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/0168-8227(90)90019-p

    authors: Ohneda A,Nihei J,Sasaki M

    更新日期:1990-01-01 00:00:00

  • The transport of vitamin E in plasma and its correlation to plasma lipoproteins in non-insulin-dependent diabetes mellitus.

    abstract::It is known that plasma low density lipoproteins (LDL) contain a great amount of vitamin E and that LDL enter cells via the specific receptor-mediated mechanism. In this study, we aimed to investigate the transport of alpha-tocopherol from plasma to tissues in subjects with non-insulin-dependent diabetes mellitus (NID...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/0168-8227(91)90018-9

    authors: Kökoğlu E,Ulakoğlu E

    更新日期:1991-12-01 00:00:00