Abstract:
AIMS:Media calcification is a predictor of cardiovascular mortality in type 2 diabetes mellitus (T2DM). Undercarboxylation of some vitamin K-dependent proteins, due to genetic polymorphisms of VKORC1, can lead to calcification. We examined a potential association between VKORC1 -1639 G>A polymorphism and T2DM and, also, the association of this polymorphism with carotid intima-media thickness (cIMT). METHODS:VKORC1 -1639 G>A polymorphism was determined in 299 T2DM patients and 328 controls of Caucasian origin using PCR-RFLP. cIMT was measured in a subgroup of 118 T2DM patients. RESULTS:The frequency of VKORC1 genotypes between diabetic and nondiabetic subjects differed significantly (p=0.01). VKORC1 genotype was associated with T2DM in an adjusted model (OR 1.36, p=0.009). A statistically significant difference was observed in the maximum value of cIMT among different genotypes. VKORC1 -1639 G>A polymorphism was an independent predictor of cIMT (p=0.029) after adjusting for established risk factors. CONCLUSIONS:The association between VKORC1 -1639 G>A polymorphism and risk of T2DM could be due to the higher prevalence of calcification in T2DM patients. This is supported by the independent association between VKORC1 -1639 G>A polymorphism and maximum cIMT in T2DM patients which is likely due to atherosclerosis characterized by increased calcification.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Tavridou A,Petridis I,Vasileiadis M,Ragia G,Heliopoulos I,Vargemezis V,Manolopoulos VGdoi
10.1016/j.diabres.2011.06.021subject
Has Abstractpub_date
2011-11-01 00:00:00pages
236-41issue
2eissn
0168-8227issn
1872-8227pii
S0168-8227(11)00343-3journal_volume
94pub_type
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