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Effect of corosolic acid on postchallenge plasma glucose levels.

Abstract：

:Corosolic acid (CRA) is a substance extracted from Lagerstroemia speciosa L. and has been reported to have biological activities in in vitro and experimental animal studies. In this study, 31 subjects were orally administered 10mg CRA or a placebo, on different occasions, in a capsule 5min before the 75-g oral glucose tolerance test (OGTT) in a double-blind and cross-over design. Nineteen subjects had diabetes, seven had impaired glucose tolerance, one had impaired fasting glucose, and four had normal glucose tolerance according to the 1998 WHO criteria. There were no significant differences in plasma glucose levels before and 30min after the administration. CRA treatment subjects showed lower glucose levels from 60min until 120min and reached statistical significance at 90min. In this study, we have shown for the first time that CRA has a lowering effect on postchallenge plasma glucose levels in vivo in humans.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Fukushima M,Matsuyama F,Ueda N,Egawa K,Takemoto J,Kajimoto Y,Yonaha N,Miura T,Kaneko T,Nishi Y,Mitsui R,Fujita Y,Yamada Y,Seino Y

doi

10.1016/j.diabres.2006.01.010

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

174-7

issue

2

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(06)00034-9

journal_volume

73

pub_type

杂志文章

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