Abstract：
AIMS:Pulmonary infections are more frequent in and associated with higher mortality in Cystic Fibrosis-Related Diabetes (CFRD) patients compared to CF patients without CFRD. Hyperglycaemia can lead to a higher vulnerability for infections. Aim of the study was to test whether the infection rate in well-controlled CFRD patients was similar to that in CF patients without CFRD. METHODS:This is a retrospective six-year cohort analysis on a consecutive series of 138 CF patients. They were categorized in two groups with CFRD or without CFRD. Pulmonary infection frequency was defined as the number of intravenous (IV) antibiotic treatments. Clinical factors associated with infection frequency were collected. RESULTS:CFRD was diagnosed in 54 (39%) CF patients of whom 44 (81%) achieved target value for glycaemic control (HbA1c 7.0% (⩽53mmol/mol)). Median frequency of IV antibiotics was 0 without CFRD and 3 episodes in patients with CFRD (rate ratio (RR) 2.9 (95% CI 1.6-5.2)). Multivariate analysis showed that frequency of IV antibiotics was significantly related to Pseudomonas aeruginosa colonization (RR 3.7) and lower lung function at baseline (RR 0.97) but not to CFRD by itself. CONCLUSIONS:In this cohort with overall strict glycaemic control, the frequency of IV antibiotics use was related to chronic infection and impaired lung function at baseline, but not to CFRD by itself. Although this study in itself does not prove beneficial effect of strict glycaemic control, it does emphasize the potential role of glycaemic control on infection frequency in CF patients.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Belle-van Meerkerk G,de Valk HW,Stam-Slob MC,Teding van Berkhout F,Zanen P,van de Graaf EAdoi
10.1016/j.diabres.2016.04.014subject
Has Abstractpub_date
2016-06-01 00:00:00pages
230-6eissn
0168-8227issn
1872-8227pii
S0168-8227(16)30078-Xjournal_volume
116pub_type
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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abstract：:The exocrine and endocrine pathophysiology of chronic calcific pancreatitis of the tropics (CCPT) remains elusive. The objective of this study was to evaluate the spectrum and correlates of the exocrine and endocrine pancreatic dysfunction in CCPT. Thirty-seven consecutive patients with a clinico-radiological diagnosi...
journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,随机对照试验
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更新日期：2006-04-01 00:00:00
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journal_title：Diabetes research and clinical practice
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doi：10.1016/s0168-8227(98)00112-0
更新日期：1999-01-01 00:00:00
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更新日期：2013-02-01 00:00:00
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journal_title：Diabetes research and clinical practice
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doi：10.1016/j.diabres.2006.10.007
更新日期：2007-07-01 00:00:00
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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更新日期：2015-12-01 00:00:00
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更新日期：2020-12-22 00:00:00
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2013.06.001
更新日期：2013-08-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(94)90040-x
更新日期：1994-01-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2012.09.009
更新日期：2012-11-01 00:00:00
abstract：AIMS:The current study sought to identify patient-level factors related to health care use among White and minority men and women with diabetes. METHODS:A sample of 447 of non-pregnant individuals with diabetes, ages 18-64, was drawn from the 2015-2016 National Health and Nutrition Examination Surveys dataset. Poisson...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：2019-04-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2020.108365
更新日期：2020-10-01 00:00:00
abstract：INTRODUCTION:The literature on health aspects of Ramadan fasting is widely spread in many journals making it not readily available to those interested in the subject. MATERIALS AND METHODS:A narrative, non-systematic review of the international literature from two major online databases (viz. Scopus, PubMed) in one ye...
journal_title：Diabetes research and clinical practice
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更新日期：2020-12-11 00:00:00
