Abstract：
AIMS:To investigate the insulin requirement profiles during short-term intensive continuous subcutaneous insulin infusion (CSII) in patients with newly diagnosed type 2 diabetes and its relationship with long-term glycemic remission. METHODS:CSII was applied in 104 patients with newly diagnosed type 2 diabetes. Daily insulin doses were titrated and recorded to achieve and maintain euglycemia for 2 weeks. Measurements of blood glucose, lipid profiles as well as intravenous glucose tolerance tests were performed before and after the therapy. Afterwards, patients were followed up for 1 year. RESULTS:Total daily insulin dose (TDD) was 56.6±16.1IU at the first day when euglycemia was achieved (TDD-1). Thereafter, TDD progressively decreased at a rate of 1.4±1.0IU/day to 36.2±16.5IU at the end of the therapy. TDD-1 could be estimated with body weight, FPG, triglyceride and waist circumference in a multiple linear regression model. Decrement of TDD after euglycemia was achieved (ΔTDD) was associated with reduction of HOMA-IR (r=0.27, P=0.008) but not with improvement in β cell function. Patients in the lower tertile of ΔTDD had a significantly higher risk of hyperglycemia relapse than those in the upper tertile within 1 year (HR 3.4, 95%CI [1.4, 8.4], P=0.008). CONCLUSIONS:There is a steady decline of TDD after euglycemia is achieved in patients with newly diagnosed type 2 diabetes treated with CSII, and ΔTDD is associated with a better long-term glycemic outcome.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Liu L,Ke W,Wan X,Zhang P,Cao X,Deng W,Li Ydoi
10.1016/j.diabres.2015.02.011subject
Has Abstractpub_date
2015-05-01 00:00:00pages
250-7issue
2eissn
0168-8227issn
1872-8227pii
S0168-8227(15)00111-4journal_volume
108pub_type
杂志文章,多中心研究,随机对照试验abstract：AIMS:Diabetes stigma and weight stigma have been identified as important but neglected issues that warrant attention among people with type 2 diabetes. This study assessed associations of diabetes stigma and weight stigma with diabetes self-care behaviors and health care in adults with type 2 diabetes. METHODS:U.S. ad...
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journal_title：Diabetes research and clinical practice
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doi：10.1016/s0168-8227(98)00048-5
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pub_type： 杂志文章,随机对照试验
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更新日期：2013-02-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：1990-07-01 00:00:00
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journal_title：Diabetes research and clinical practice
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更新日期：2014-08-01 00:00:00
