Abstract：
OBJECTIVE:To examine change of diagnosis in patients from the German/Austrian multicenter DPV (Diabetes Patienten Verlaufsdokumentation) database initially classified as type 2 diabetes. METHODS:Patients aged ≤20 years at onset, diagnosed between 1995 and 2010 were followed for at least 6 months. Chi-square/Wilcoxon tests were performed to compare patient groups according to diabetes type after reclassification. RESULTS:From 580 study patients, 60 (10.3%) were reclassified, on average 2.4 years after initial diagnosis as follows: 23 (38.3%) as type 1 diabetes; 9 (15%) as maturity onset diabetes of the young (MODY); 20 (33.3%) as "other specific diabetes forms" and 8 (13.3%) as "remission" of type 2 diabetes. Patients reclassified to type 1 were significantly younger (13.5 ± 2.9 versus 14.0 ± 2.6; p=0.027) and more often β-cell antibody positive at disease onset (80.0% versus 31.2%; p=0.002), while patients reclassified as MODY had significantly lower BMI-SDS values than 520 patients with confirmed type 2 diabetes (2.5 ± 1.1 versus 0.9 ± 1.1; p<0.001). The latter were also considerably more obese than patients in "remission" and those reclassified to "other specific diabetes forms". CONCLUSION:About 10% of patients in the DPV database, initially diagnosed as type 2 diabetes, were retrospectively reclassified.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Awa WL,Schober E,Wiegand S,Herwig J,Meissner T,Schmidt F,Molz E,Holl RWdoi
10.1016/j.diabres.2011.09.011subject
Has Abstractpub_date
2011-12-01 00:00:00pages
463-7issue
3eissn
0168-8227issn
1872-8227pii
S0168-8227(11)00499-2journal_volume
94pub_type
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2006.12.017
更新日期：2007-09-01 00:00:00
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journal_title：Diabetes research and clinical practice
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pub_type： 杂志文章
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更新日期：1994-01-01 00:00:00
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pub_type： 杂志文章
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