Abstract:
:We present a model of cell motility generated by actomyosin contraction of the cell cortex. We identify, analytically, dynamical instabilities of the cortex and show that they yield steady-state cortical flows, which, in turn, can induce cell migration in three-dimensional environments. This mechanism relies on the regulation of contractility by myosin, whose transport is explicitly taken into account in the model. Theoretical predictions are compared to experimental data of tumor cells migrating in three-dimensional matrigel and suggest that this mechanism could be a general mode of cell migration in three-dimensional environments.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Hawkins RJ,Poincloux R,Bénichou O,Piel M,Chavrier P,Voituriez Rdoi
10.1016/j.bpj.2011.07.038subject
Has Abstractpub_date
2011-09-07 00:00:00pages
1041-5issue
5eissn
0006-3495issn
1542-0086pii
S0006-3495(11)00896-4journal_volume
101pub_type
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