Abstract:
:Many signaling pathways act through shared components, where different ligand molecules bind the same receptors or activate overlapping sets of response regulators downstream. Nevertheless, different ligands acting through cross-wired pathways often lead to different outcomes in terms of the target cell behavior and function. Although a number of mechanisms have been proposed, it still largely remains unclear how cells can reliably discriminate different molecular ligands under such circumstances. Here we show that signaling via ligand-induced receptor dimerization-a very common motif in cellular signaling-naturally incorporates a mechanism for the discrimination of ligands acting through the same receptor.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Fathi S,Nayak CR,Feld JJ,Zilman AGdoi
10.1016/j.bpj.2016.07.029subject
Has Abstractpub_date
2016-09-06 00:00:00pages
917-20issue
5eissn
0006-3495issn
1542-0086pii
S0006-3495(16)30598-7journal_volume
111pub_type
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