Risk factors associated with typhoid fever in children aged 2-16 years in Karachi, Pakistan.

Abstract:

:We analysed the data from the control group in a typhoid vaccine trial in Karachi to assess the differences in individual-, household- and cluster-level characteristics for developing typhoid fever. The annual incidence of typhoid in children aged 2-16 years in the control arm of the vaccine trial was 151/100 000 population. After adjustment, the risk of typhoid was lower with increasing age [risk ratio (RR) 0·89, 95% confidence interval (CI) 0·83-0·95], was higher with an increase in population density (RR 1·13, 95% CI 1·05-1·21) and was lower in the households using a safe drinking-water source (RR 0·63, 95% CI 0·41-0·99). Typhoid fever affects younger children living in areas of high population density and lack of access to safe water in Pakistan. A combination of environmental and biological interventions is required to prevent the continued epidemiological and economic impact of typhoid fever in high-risk areas of Pakistan.

journal_name

Epidemiol Infect

authors

Khan MI,Ochiai RL,Soofi SB,Von-Seidlein L,Khan MJ,Sahito SM,Habib MA,Puri MK,Park JK,You YA,Ali M,Nizami SQ,Acosta CJ,Bradley-Sack R,Clemens JD,Bhutta ZA

doi

10.1017/S0950268811000938

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

665-72

issue

4

eissn

0950-2688

issn

1469-4409

pii

S0950268811000938

journal_volume

140

pub_type

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