Abstract:
:The 7-valent pneumococcal conjugate vaccine (PCV7) is reported to decrease the incidence of community-acquired pneumonia (CAP) in children. To determine the annual incidence of CAP before the introduction of PCV7, we counted the number of children hospitalized with CAP between 2008 and 2009 in Chiba City, Japan. We investigated serotype and multilocus sequence typing (MLST) for Streptococcus pneumoniae isolates in CAP cases. The annual incidence of hospitalized CAP in children aged <5 years was 17.6 episodes/1000 child-years. In 626 episodes, S. pneumoniae was dominant in 14.7% and 0.8% of sputum and blood samples, respectively. The most common serotypes were 6B, 23F and 19F. The coverage rates of PCV7 were 66.7% and 80% in sputum samples and blood samples, respectively. MLST analysis revealed 37 sequence types. Furthermore, 54.1% of the sputum isolates and 40% of the blood isolate were related to international multidrug-resistant clones.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Tanaka J,Ishiwada N,Wada A,Chang B,Hishiki H,Kurosaki T,Kohno Ydoi
10.1017/S0950268811001592subject
Has Abstractpub_date
2012-06-01 00:00:00pages
1111-21issue
6eissn
0950-2688issn
1469-4409pii
S0950268811001592journal_volume
140pub_type
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