Nocturnal blood pressure nondipping in obese African-Americans.

Abstract:

OBJECTIVES:Nondipping pattern of circadian blood pressure (BP) is associated with increased cardiovascular morbidity and mortality; however, limited data are available among obese African-Americans. We, therefore, aimed to evaluate the pattern of circadian BP variation and to identify clinical conditions associated with nondipping in this population. METHODS:A total of 211 obese African-Americans enrolled in a weight-reduction program underwent 24-h ambulatory BP monitoring. Nondipping was defined as a nocturnal BP reduction of less than 10%. RESULTS:Systolic BP (SBP) nondipping was present in 158 participants (74.9%) and diastolic BP (DBP) nondipping was present in 93 participants (44.1%). In multivariate logistic regression analyses, diabetes was associated with SBP nondipping (adjusted OR, 2.53; CI: 1.16-5.76; P=0.02), and increasing BMI (5 kg/m) was associated with DBP nondipping (adjusted OR, 1.46; CI: 1.17-1.83; P=0.001). In linear regression analyses, BMI was positively correlated to office, 24-h, daytime, and night-time SBP (P=0.03, 0.01, 0.03, and 0.005, respectively) and office, 24-h, daytime, and night-time PP (P=0.01, P<0.001, 0.001, and P=0.003, respectively). CONCLUSION:This study demonstrated an excessively high prevalence of nondippers and independent associations between diabetes and SBP nondipping and between BMI and DBP nondipping in an obese African-American population.

journal_name

Blood Press Monit

authors

Napan S,Kwagyan J,Randall OS,Xu S,Ketete M,Maqbool AR

doi

10.1097/MBP.0b013e328346a871

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

111-6

issue

3

eissn

1359-5237

issn

1473-5725

journal_volume

16

pub_type

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