Differential effects of antihypertensive drugs on circadian rhythm in blood pressure from the chronobiological point of view.

Abstract:

:REVIEW IN DEPTH: The cardiovascular system is well organized in time. The blood pressure normally displays a circadian rhythm characterized by a nightly drop which, however, can be disturbed by disease. The 24 h blood pressure and its mechanisms of regulation are very dynamic and rhythmic processes. Ambulatory blood pressure monitoring data should, therefore, be analysed by more subtle methods than linear or cosinor analysis. The blood pressure lowering effects and the dose-reponse relationship of antihypertensive drugs can also be circadian phase-dependent. Antihypertensive drug treatment should not only aim to lower blood pressure but also to achieve a normal 24 h blood pressure pattern. Finally, when evaluating the duration of action it is mendatory to register the blood pressure by ambulatory monitoring for more than 24 h.

journal_name

Blood Press Monit

authors

Lemmer B

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

161-169

issue

2

eissn

1359-5237

issn

1473-5725

journal_volume

1

pub_type

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