Effect of bedtime melatonin ingestion on blood pressure of normotensive subjects.

Abstract:

:OBJECTIVE: To determine whether the evening intake of 5 mg melatonin affects 24 h arterial blood pressure and heart-rate profiles. METHODS: Twenty-one young normotensive subjects were administered placebo or melatonin for 4 weeks, according to a cross-over double-blind design, and were subjected to ambulatory blood pressure monitoring on the first and last days of each treatment period. RESULTS: The chronic melatonin intake caused a decrease in systolic blood pressure throughout the 24 h period (109.1+/- 7.2 versus 113.6 +/- 8.15 mmHg, P < 0.05), a decrease in diastolic blood pressure (by 6.4 mmHg, P < 0.05) limited to the second half of the night, a slight lowering of the heart rate during the diurnal hours (78.6 +/- 7.6 versus 81.5 +/- 10.1 beats/min, P < 0.05) and an acceleration of a similar degree during the second half of the night. The slight hypotensive action and the diurnal heart-rate lowering may be explained theoretically in terms of various complex and synergistic mechanisms that so far have been verified only in experimental studies on animals. The etiology of the nocturnal heart-rate acceleration remains unknoiwn. Further controlled studies are needed in order to better understand the cardiovascular effects of melatonin and to evaluate possible pharmacologic interactions. CONCLUSION:

journal_name

Blood Press Monit

authors

Lusardi P,Preti P,Savino S,Piazza E,Zoppi A,Fogari R

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

99-103

issue

2

eissn

1359-5237

issn

1473-5725

journal_volume

2

pub_type

杂志文章
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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:

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    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

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    更新日期:1997-12-01 00:00:00

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    更新日期:2004-10-01 00:00:00

  • Comparison of central blood pressure devices on the basis of a modified protocol of the European Society of Hypertension: application to the Centron cBP301.

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    pub_type: 杂志文章

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    authors: Agnoletti D,Millasseau S,Topouchian J,Safar ME,Blacher J

    更新日期:2014-04-01 00:00:00

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    更新日期:2011-06-01 00:00:00

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