Common genomic aberrations in basaloid squamous cell carcinoma and carcinosarcoma of the esophagus detected by CGH and array CGH.

Abstract:

:Basaloid squamous cell carcinoma (BSCC) and carcinosarcoma of the esophagus are rare entities, making up fewer than 2% of esophageal malignancies. Comparative genomic hybridization (CGH) in 1 case of BSCC and 2 cases of carcinosarcoma and subsequent array CGH in 1 case each of BSCC and carcinosarcoma revealed common chromosomal gains at 2p25.3-2p12, 7q21.3-7q22.3, and 11q13.2-11q13.4. Chromosomal losses at 13q31qter were observed in both carcinosarcomas. In addition, progression of genomic instability from in situ to invasive carcinosarcoma could be demonstrated by using array CGH. Our observations suggest a common genetic origin of BSCC and carcinosarcoma.

journal_name

Am J Clin Pathol

authors

Schaefer IM,Enders C,Polten A,Haller F,Frölich AM,Cameron S,Schüler P,Schweiger P,Gunawan B,Beham A,Füzesi L

doi

10.1309/AJCPZ1O7UUUISPNR

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

579-86

issue

4

eissn

0002-9173

issn

1943-7722

pii

135/4/579

journal_volume

135

pub_type

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