Lifestyle and cardiovascular disease in Japan.

abstract：AIM:Both vascular function and structure are independent predictors of cardiovascular events. The purpose of this study was to evaluate vascular function and structure of a leg artery in patients with peripheral artery disease (PAD). METHODS:We measured flow-mediated vasodilatation (FMD) and nitroglycerine-induced vas...

journal_title：Journal of atherosclerosis and thrombosis

authors： Iwamoto A,Kajikawa M,Maruhashi T,Iwamoto Y,Oda N,Kishimoto S,Matsui S,Kihara Y,Chayama K,Goto C,Noma K,Aibara Y,Nakashima A,Higashi Y

更新日期：2016-11-01 00:00:00

abstract：:We tried to investigate whether accumulation of visceral fat assessed by a simple but widely used ultrasonography was associated with common carotid atherosclerosis in women. The subjects were consecutively admitted in-patients whose body mass index was more than 22 kg/m2. Those with cardiorenal or nutritional disorde...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kawamoto R,Kajiwara T,Oka Y,Takagi Y

更新日期：2002-01-01 00:00:00

abstract：AIM:Soluble cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1, E-selectin, and P-selectin, have been suggested to be associated with cardiovascular disease (CVD) risk; however, the nature and magnitude of the association between VCAM-1 and CVD risk is uncerta...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kunutsor SK,Bakker SJL,Dullaart RPF

更新日期：2017-08-01 00:00:00

abstract：AIM:Aim of this study was to directly detect increased permeability of vascular lesions by magnetic resonance imaging. METHODS:A novel contrast medium with a mean hydrodynamic diameter of 100 nm was prepared from monodispersed iron colloids incorporated into micelles of block copolymers composed of polyethylene glycol...

journal_title：Journal of atherosclerosis and thrombosis

authors： Imai Y,Kaneko E,Asano T,Kumagai M,Ai M,Kawakami A,Kataoka K,Shimokado K

更新日期：2007-04-01 00:00:00

abstract：:Normal and alloxan diabetic rats were kept on a 0.25% cholesterol diet for 12 months and the changes in serum cholesterol levels, and fecal excretion of sterols and bile acids were examined to elucidate the influence of changes in bile acid metabolism on manifestations of hypercholesterolemia and development of athero...

journal_title：Journal of atherosclerosis and thrombosis

authors： Uchida K,Satoh T,Takase H,Nomura Y,Takasu N,Kurihara H,Takeuchi N

更新日期：1996-01-01 00:00:00

abstract：AIM:The adipocyte-derived hormone leptin plays a key role in the regulation of food intake and energy expenditure. Recent studies have suggested that leptin is also involved in the pathogenesis of obesity-associated atherosclerosis and cardiovascular disease. In this study, we investigated the associations of leptin an...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yamazaki Y,Emoto M,Morioka T,Kawano N,Lee E,Urata H,Tsuchikura S,Motoyama K,Mori K,Fukumoto S,Shoji T,Nishizawa Y,Inaba M

更新日期：2013-01-01 00:00:00

abstract：AIMS:The clinical implications of stiffness of the carotid artery (CA) have not been fully clarified in the prediction of coronary artery disease (CAD), although intima-media thickness (IMT) has been established as a surrogate marker. We examined the associations of stiffness parameter beta (ST) and IMT with concurrent...

journal_title：Journal of atherosclerosis and thrombosis

authors： Lee E,Emoto M,Teramura M,Tsuchikura S,Ueno H,Shinohara K,Morioka T,Mori K,Koyama H,Shoji T,Okuno Y,Inaba M,Nishizawa Y

更新日期：2009-03-01 00:00:00

abstract：AIM:The arterial pressure-volume index (API) and arterial velocity-pulse index (AVI) are novel measurement indices of arterial stiffness. This study was performed to examine the screening validity of the API and AVI for preclinical atherosclerosis in Japanese community-dwelling adults. METHODS:We conducted a cross-sec...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yamanashi H,Koyamatsu J,Nagayoshi M,Shimizu Y,Kawashiri SY,Kondo H,Fukui S,Tamai M,Maeda T

更新日期：2018-09-01 00:00:00

abstract：AIM:Individuals with type 2 diabetes are at high risk for cardiovascular events; however, a modality that could reduce risk has not been fully evaluated. We examined the annual incidence rate of cardiovascular events in asymptomatic Japanese diabetic patients who underwent gated myocardial perfusion single-photon compu...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yamasaki Y,Katakami N,Kaneto H,Nakajima K,Kusuoka H,Kashiwagi A,Nishimura T

更新日期：2013-01-01 00:00:00

abstract：AIM:Speckle-tracking imaging has been introduced for the precise assessment of vessel mechanics. However, there are no data on the role of this imaging tool in assessing the changes in vasculature with statin therapy, which is known to enhance vascular elasticity. METHODS:This study was a prospective study including 4...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hae Kim C,Wang S,Park JB,Jung KH,E Yoon Y,Lee SP,Kim HK,Kim YJ,Cho GY,Sohn DW

更新日期：2018-11-01 00:00:00

abstract：AIM:Ezetimibe, an inhibitor of cholesterol intestinal absorption, is a lipid lowering agent. However, anti-atherogenic effects of ezetimibe have not been fully elucidated. Therefore, the objective in this study was to clarify the vascular protective effects of ezetimibe in patients with hypercholesterolemia. METHODS:E...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kurobe H,Aihara K,Higashida M,Hirata Y,Nishiya M,Matsuoka Y,Kanbara T,Nakayama T,Kinoshita H,Sugano M,Fujimoto E,Kurobe A,Sugasawa N,Kitaichi T,Akaike M,Sata M,Matsumoto T,Kitagawa T

更新日期：2011-01-01 00:00:00

abstract：:Although many clinical studies have shown that a low testosterone level is associated with cardiovascular diseases, the role of androgens in cardiovascular physiology and pathophysiology remains controversial. Androgens exert various actions in their target organs, and the androgen receptor (AR) is widely distributed ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yoshida S,Ikeda Y,Aihara K

更新日期：2016-01-01 00:00:00

abstract：AIMS:Type 2 diabetes mellitus (T2DM) is no longer regarded as a coronary risk equivalent, and heterogeneity of cardiovascular risk exists, suggesting that further risk stratification should be mandatory. This study aimed to determine the prevalence and clinical predictors of coronary artery calcium (CAC) score, and eva...

journal_title：Journal of atherosclerosis and thrombosis

authors： Lei MH,Wu YL,Chung SL,Chen CC,Chen WC,Hsu YC

更新日期：2020-11-07 00:00:00

abstract：AIM:We have conducted medical surveys on two Japanese populations (Japanese Americans living in the US and native Japanese living in Japan) to investigate the impact of westernization of lifestyles on diseases in Japanese people. A 1998 survey revealed that the progression of carotid intima-media wall thickness (IMT) w...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kubota M,Yoneda M,Watanabe H,Egusa G

更新日期：2017-10-01 00:00:00

abstract：AIM:Associations between long-term exposure to particulate matter (PM) and increased cardiovascular mortality have been reported, but few studies have investigated the associated incidence of cardiovascular disease, and none involved men. METHODS:We used data on 78,057 participants (37,121 men, 40,936 women) to examin...

journal_title：Journal of atherosclerosis and thrombosis

authors： Nishiwaki Y,Michikawa T,Takebayashi T,Nitta H,Iso H,Inoue M,Tsugane S,Japan Public Health Center-based Prospective Study Group.

更新日期：2013-01-01 00:00:00

abstract：AIM:The aim of this study was to assess the association between weight change and mortality due to cardiovascular diseases (CVDs) in a Japanese population. METHODS:We used the data of a population-based prospective cohort study that was conducted from 1988 to 1990 in 45 areas throughout Japan. Among a total of 69,681 ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Okada C,Kubota Y,Eshak ES,Cui R,Tamakoshi A,Iso H,and the JACC Study Group.

更新日期：2021-01-01 00:00:00

abstract：AIM:This study aimed to examine whether cardiorespiratory fitness (CRF) is associated with arterial stiffening, evaluated using the cardio-ankle vascular index (CAVI), independent of visceral fat (VF) in middle-aged and elderly Japanese men. We also examined whether the relationship between CRF and the CAVI is modified...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tanisawa K,Ito T,Sun X,Kawakami R,Oshima S,Gando Y,Cao ZB,Sakamoto S,Higuchi M

更新日期：2015-01-01 00:00:00

abstract：AIM:The clinical relevance of the suggested pleiotropic effects of hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) is controversial. Aggressive statins effectively reduce lipid levels, but whether their other effects are more powerful than those of regular statins is unknown. METHODS:We enrolled 32 pat...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hoshiga M,Arishiro K,Nakakoji T,Miyazaki N,Negoro N,Okabe T,Kohbayashi E,Ishihara T,Hanafusa T

更新日期：2010-07-30 00:00:00

abstract：AIM:Atrial fibrillation (AF) is characterized by the development of thromboembolic events and is more prevalent among end-stage renal disease patients than in the general population. Vascular access thrombosis (VAT) is a major morbidity in chronic hemodialysis (HD) patients; however, the association between AF and VAT ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Chou CY,Chen JY,Liu JH,Liu YL,Lin HH,Yang YF,Wang SM,Kuo HL,Huang CC

更新日期：2011-01-01 00:00:00

abstract：AIM:Hypercholesterolemic patients with inflammation are at high risk for cardiovascular events. Statins exert anti-inflammatory action independent of their cholesterol-lowering action. This study sought to clarify whether statin therapy reduces inflammatory markers in hypercholesterolemic patients and to determine fact...

journal_title：Journal of atherosclerosis and thrombosis

authors： Horiuchi Y,Hirayama S,Soda S,Seino U,Kon M,Ueno T,Idei M,Hanyu O,Tsuda T,Ohmura H,Miida T

更新日期：2010-07-30 00:00:00

abstract：AIM:A novel device has been developed for measuring the cardio-ankle vascular index (CAVI) as an indicator of arterial stiffness. In this study, we evaluated the effect of pitavastatin on CAVI in type 2 diabetic patients. METHODS:Forty-five type 2 diabetes mellitus patients with low-density lipoprotein cholesterolemia...

journal_title：Journal of atherosclerosis and thrombosis

authors： Miyashita Y,Endo K,Saiki A,Ban N,Yamaguchi T,Kawana H,Nagayama D,Ohira M,Oyama T,Shirai K

更新日期：2009-10-01 00:00:00

abstract：AIM:Withholding effective treatment is clinically prevalent. The CEntralized Pan-Asian survey on tHE Under-treatment of hypercholeSterolemia (CEPHEUS-PA) indicated suboptimal low-density lipoprotein cholesterol (LDL-C) goal attainment in Taiwan, which may be attributable to clinical inertia. We herein analyzed the Taiw...

journal_title：Journal of atherosclerosis and thrombosis

authors： Wang KL,Wu CH,Wang KF,Chang CC,Chen LC,Lu TM,Lin SJ,Chiang CE

更新日期：2014-01-01 00:00:00

abstract：:Cardiovascular disease constitutes the major cause of mortality in patients with chronic kidney disease. Arterial stiffness is an important contributor to the occurrence and progression of cardiovascular disease. Various risk factors, including altered hormone levels, have been suggested to be associated with arterial...

journal_title：Journal of atherosclerosis and thrombosis

authors： Gungor O,Kircelli F,Voroneanu L,Covic A,Ok E

更新日期：2013-01-01 00:00:00

abstract：AIM:Studies have suggested that genetic and environmental factors do not account for all risks and mechanisms of intracranial atherosclerotic stenosis (ICAS). DNA methylation may play a role in the progression of ICAS. METHODS:DNA methylation profiles of peripheral blood leucocytes from 7 patients with early-onset ICA...

journal_title：Journal of atherosclerosis and thrombosis

authors： He XW,Zhao Y,Shi YH,Zhao R,Liu YS,Hu Y,Zhuang MT,Wu YL,Li GF,Yin JW,Cui GH,Liu JR

更新日期：2020-01-01 00:00:00

abstract：AIM:Recent studies have suggested that hyperinsulinemia is associated with high cardiovascular risk. The purpose of this study was to assess the relationship between the serum insulin level and coronary artery calcification (CAC). METHODS:We performed a cross-sectional study of 582 consecutive and nondiabetic particip...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tanaka M,Fukui M,Tomiyasu K,Akabame S,Nakano K,Hasegawa G,Oda Y,Nakamura N

更新日期：2010-10-27 00:00:00

abstract：:Rats with alloxan-induced diabetes developed severe atherosclerotic lesions when they were maintained on a 0.25% cholesterol diet for one year. The atheromatous changes developed at the aortic arch, appeared as early as 3 months after the start of the experiment, and increased thereafter. The diabetic rats also develo...

journal_title：Journal of atherosclerosis and thrombosis

authors： Uchida K,Takase H,Nomura Y,Nakamura Y,Igimi H,Takasu N,Kurihara H,Takeuchi N

更新日期：1994-01-01 00:00:00

abstract：AIMS:Renal dysfunction is a major public health problem, but there have been few investigations of the relationship between serum high molecular weight (HMW) adiponectin and renal function in Japanese community-dwelling adults. METHODS:We randomly recruited a sample of 1,849 adult Japanese (793 men aged 60 ± 14 (mean ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kawamoto R,Tabara Y,Kohara K,Miki T,Abe M,Kusunoki T,Katoh T,Ohtsuka N

更新日期：2010-11-27 00:00:00

abstract：AIM:The Japan EPA Lipid Intervention Study (JELIS) reported a 19% reduction of the risk for coronary artery disease after long-term use of pure eicosapentaenoic acid (EPA) in Japanese patients with hypercholesterolemia. The variation in plasma fatty acid composition influenced the risk of coronary events. The aim of th...

journal_title：Journal of atherosclerosis and thrombosis

authors： Itakura H,Yokoyama M,Matsuzaki M,Saito Y,Origasa H,Ishikawa Y,Oikawa S,Sasaki J,Hishida H,Kita T,Kitabatake A,Nakaya N,Sakata T,Shimada K,Shirato K,Matsuzawa Y,JELIS.

更新日期：2012-01-01 00:00:00

abstract：:Dysregulation of adipose tissue-derived bioactive molecules, termed adipokines, is recognized as common ground for insulin resistance and metabolic syndrome associated with obesity. However, adipokine dysregulation is paradoxically associated with lipodystrophy and lipoatrophy with aging. In familial partial lipodystr...

journal_title：Journal of atherosclerosis and thrombosis

authors： Arai Y,Takayama M,Abe Y,Hirose N

更新日期：2011-01-01 00:00:00

abstract：:Patients with chronic kidney disease (CKD) are at an increased risk not only for end-stage kidney disease (ESKD) but also for cardiovascular disease (CVD). In this review article, we summarize the current evidence of CKD as a high-risk condition for CVD based on reports from Japan and other countries to draw attention...

journal_title：Journal of atherosclerosis and thrombosis

authors： Shoji T,Abe T,Matsuo H,Egusa G,Yamasaki Y,Kashihara N,Shirai K,Kashiwagi A,Committee of Renal and Peripheral Arteries, Japan Atherosclerosis Society.

更新日期：2012-01-01 00:00:00