Abstract:
AIM:Hypercholesterolemic patients with inflammation are at high risk for cardiovascular events. Statins exert anti-inflammatory action independent of their cholesterol-lowering action. This study sought to clarify whether statin therapy reduces inflammatory markers in hypercholesterolemic patients and to determine factors that predict the reduction in these markers. METHODS:Fasting concentrations of lipoproteins and inflammatory markers were measured in 54 hypercholesterolemic patients, and age- and gender-matched healthy volunteers. Carotid atherosclerosis was determined by ultrasonography. Blood samples were also analyzed in hypercholesterolemic patients after 4 weeks of statin therapy. RESULTS:The high-sensitivity C-reactive protein (hs-CRP) and serum amyloid A (SAA) protein concentrations did not differ between the two groups. Statin therapy reduced the median hs-CRP and SAA concentrations in hypercholesterolemic patients from 0.75 to 0.60 mg/L (p=0.05), and from 3.95 to 3.20 microg/mL (p=0.20), respectively. These reductions were significant for both markers, but only in subgroups with high baseline concentrations. Statins exhibited different results for hs-CRP and SAA in the presence of carotid atherosclerosis. CONCLUSIONS:Statin therapy reduces inflammatory markers in hypercholesterolemic patients, and this anti-inflammatory action is limited to patients whose inflammatory markers are elevated at baseline.
journal_name
J Atheroscler Thrombjournal_title
Journal of atherosclerosis and thrombosisauthors
Horiuchi Y,Hirayama S,Soda S,Seino U,Kon M,Ueno T,Idei M,Hanyu O,Tsuda T,Ohmura H,Miida Tdoi
10.5551/jat.3632subject
Has Abstractpub_date
2010-07-30 00:00:00pages
722-9issue
7eissn
1340-3478issn
1880-3873pii
JST.JSTAGE/jat/3632journal_volume
17pub_type
杂志文章abstract:AIM:To examine the impact of C-reactive protein on the risks of stroke and its subtypes, particularly among Asian populations in which median C-reactive protein levels are typically lower than in Western populations. METHODS:A prospective, nested case-control study was conducted to examine the associations between hig...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
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doi:10.5551/jat.12.295
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat1994.2.supplement1_s36
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of atherosclerosis and thrombosis
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pub_type: 杂志文章
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