Clinical implications of the coronary artery calcium score in Japanese patients.

abstract：AIM:Clinical studies have suggested that renin-angiotensin inhibitors are effective for the prevention of atherosclerosis progression, but the results for the regression of established lesions are equivocal. The aim of this study was to examine the effects of different doses of the angiotensin receptor blocker (ARB) ca...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hayashi K,Sasamura H,Azegami T,Itoh H

更新日期：2012-01-01 00:00:00

abstract：AIM:Angiotensin (Ang) II-induced abdominal aortic aneurysm (AAA) in apoE-deficient mice has been used as a model of human AAA, but it has been unclear why the progression of AAA continues after stopping the Ang II infusion. The involvement of vascular Ang II-forming enzymes in the progression of AAA was studied. METHO...

journal_title：Journal of atherosclerosis and thrombosis

authors： Inoue N,Muramatsu M,Jin D,Takai S,Hayashi T,Katayama H,Kitaura Y,Tamai H,Miyazaki M

更新日期：2009-06-01 00:00:00

abstract：:Our purpose was to determine whether lipid peroxides are elevated in the plasma of patients with non-insulin dependent diabetes with multiple lacunar infarcts as detected by magnetic resonance imaging (MRI), and to confirm whether peroxide levels correlate with glycemic controls and blood lipid levels. The level of li...

journal_title：Journal of atherosclerosis and thrombosis

authors： Fujiwara Y,Nishihara H,Nakakoshi T,Hasegawa T,Tagami S,Kawakami Y

更新日期：1997-01-01 00:00:00

abstract：AIM:To evaluate the effect of statin therapy on the decrease of common carotid artery intima-media thickness (CCA-IMT) compared to placebo or usual care. METHODS:A systematic search of electronic databases (MEDLINE, EMBASE, and Cochrane Center Register) up to December 2011 was performed. Two reviewers independently de...

journal_title：Journal of atherosclerosis and thrombosis

authors： Huang Y,Li W,Dong L,Li R,Wu Y

更新日期：2013-01-01 00:00:00

abstract：AIM:Ischemic stroke (IS) is a multifactorial disease caused by environmental risk factors and genetic susceptibility. However, few studies have assessed whether gene-gene interactions among cytochrome P450 (CYP) pathway genes influence the risk of IS. The aim of the present study was to investigate the association of 1...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yi X,Liao D,Fu X,Zhang B,Wang C

更新日期：2015-01-01 00:00:00

abstract：AIM:To properly assess the guidance for perioperative management, we undertook a clinical epidemiology study with the primary aim of evaluating the incidence of perioperative vascular complications and their associated factors in a cohort of Japanese patients who underwent non-cardiac surgery in a tertiary medical care...

journal_title：Journal of atherosclerosis and thrombosis

authors： Aoyama-Mani C,Kawachi S,Ogawa Y,Kato N

更新日期：2014-01-01 00:00:00

abstract：AIMS:Profiling of lipoproteins can predict risk of cardiovascular disease; gel permeation high-performance liquid chromatography (HPLC) improves prediction accuracy by providing detailed data for specific lipoprotein subclasses. This study applied HPLC to examine the effects of evolocumab, which effectively treats hype...

journal_title：Journal of atherosclerosis and thrombosis

authors： Masuda D,Kiyosue A,Hirayama A,Shimauchi J,López JAG,Miyawaki K,Yamashita S

更新日期：2020-11-01 00:00:00

abstract：AIM:To investigate the association between arterial stiffness (present with brachial-ankle pulse wave velocity (baPWV)) and metabolic syndrome (MetS) in a population-based study of middle-aged Chinese. METHODS:MetS was defined using the AHA/NHLBI criteria. A total of 1,018 subjects aged 40 years and over were recruite...

journal_title：Journal of atherosclerosis and thrombosis

authors： Lin WY,Lai MM,Li CI,Lin CC,Li TC,Chen CC,Lin T,Liu CS

更新日期：2009-04-01 00:00:00

abstract：AIM:We investigated the effects of a calorie-restricted low-carbohydrate diet on glucose and lipid metabolism, and body fat distribution, especially on the secretion of leptin and lipoprotein lipase from adipose tissue in Otsuka Long Evans Tokushima Fatty (OLETF) rats. METHODS:Forty-three week-old male OLETF rats were...

journal_title：Journal of atherosclerosis and thrombosis

authors： Koide N,Oyama T,Miyashita Y,Shirai K

更新日期：2007-10-01 00:00:00

abstract：AIM:Smoking induces vascular inflammation and increases the risk of cardiovascular events. Lectinlike oxidized low-density lipoprotein receptor-1 (LOX-1) is a scavenger receptor that is induced by oxidative stress and is associated with atherosclerotic plaque formation and destabilization. LOX-1 interacts with C-reacti...

journal_title：Journal of atherosclerosis and thrombosis

authors： Takanabe-Mori R,Ono K,Wada H,Takaya T,Ura S,Yamakage H,Satoh-Asahara N,Shimatsu A,Takahashi Y,Fujita M,Fujita Y,Sawamura T,Hasegawa K

更新日期：2013-01-01 00:00:00

abstract：:Receptors belonging to the low density lipoprotein receptor (LDLR) superfamily play important biological roles in addition to mediating the lipoprotein metabolism. The recent discovery of a novel mosaic LDLR family member by us (Yamazaki H, Bujo H, Kusunoki J, Seimiya K, Kanaki T, Morisaki N, Schneider WJ, and Saito Y...

journal_title：Journal of atherosclerosis and thrombosis

authors： Bujo H,Saito Y

更新日期：2000-01-01 00:00:00

abstract：AIMS:Statins not only reduce low-density lipoprotein (LDL) cholesterol, but also prevent the progression of kidney dysfunction. Ezetimibe, a cholesterol-absorption inhibitor, also lowers LDL cholesterol levels when added to statins; however, the effect of add-on ezetimibe on kidney function has had conflicting results....

journal_title：Journal of atherosclerosis and thrombosis

authors： Kinouchi K,Ichihara A,Bokuda K,Morimoto S,Itoh H

更新日期：2013-01-01 00:00:00

abstract：:Zetia (ezetimibe) is a selective cholesterol absorption inhibitor, which potently inhibits the absorption of biliary and dietary cholesterol from the small intestine without affecting the absorption of fat-soluble vitamins, triglycerides or bile acids. Ezetimibe reduces the small intestinal enterocyte uptake and absor...

journal_title：Journal of atherosclerosis and thrombosis

authors： Davis HR,Veltri EP

更新日期：2007-06-01 00:00:00

abstract：AIMS:Adiponectin, an adipocyte-specific secretory protein, abundantly exists in the blood stream while its concentration paradoxically decreases in obesity. Hypoadiponectinemia is one of risks of cardiovascular diseases. However, impact of serum adiponectin concentration on acute ischemic myocardial damages has not bee...

journal_title：Journal of atherosclerosis and thrombosis

authors： Natsukawa T,Maeda N,Fukuda S,Yamaoka M,Fujishima Y,Nagao H,Sato F,Nishizawa H,Sawano H,Hayashi Y,Funahashi T,Kai T,Shimomura I

更新日期：2017-08-01 00:00:00

abstract：AIMS:Cardiovascular disease (CVD) remains the leading cause of death worldwide despite improvements in the treatment of atherosclerosis, an inflammatory disease and major underlying cause of CVD. Monocytes, an innate immune cell type, are linked to CVD progression; however, given their heterogeneity, the association be...

journal_title：Journal of atherosclerosis and thrombosis

authors： SahBandar IN,Ndhlovu LC,Saiki K,Kohorn LB,Peterson MM,D'Antoni ML,Shiramizu B,Shikuma CM,Chow DC

更新日期：2020-05-01 00:00:00

abstract：AIM:Atherosclerosis (AS) characterized as a chronic inflammatory disease. Multiple immune cells and inflammatory cytokines, such as high mobility group protein (HMGB1), regulatory T (Treg) cells, T helper (Th17) cells, and inflammation-related cytokines, play a key role in its pathophysiology. A large number of studies...

journal_title：Journal of atherosclerosis and thrombosis

authors： Ding JW,Zheng XX,Zhou T,Tong XH,Luo CY,Wang XA

更新日期：2016-06-01 00:00:00

abstract：AIM:Ezetimibe, an inhibitor of cholesterol intestinal absorption, is a lipid lowering agent. However, anti-atherogenic effects of ezetimibe have not been fully elucidated. Therefore, the objective in this study was to clarify the vascular protective effects of ezetimibe in patients with hypercholesterolemia. METHODS:E...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kurobe H,Aihara K,Higashida M,Hirata Y,Nishiya M,Matsuoka Y,Kanbara T,Nakayama T,Kinoshita H,Sugano M,Fujimoto E,Kurobe A,Sugasawa N,Kitaichi T,Akaike M,Sata M,Matsumoto T,Kitagawa T

更新日期：2011-01-01 00:00:00

abstract：AIM:Existing evidence suggests that endothelial lipase (EL) plays an important role in high-densitylipoprotein (HDL) metabolism. Because rabbits are a useful animal model for the study of human lipid metabolism and atherosclerosis, we characterized rabbit EL (rEL) expression and investigated its relationship with plasm...

journal_title：Journal of atherosclerosis and thrombosis

authors： Zhang J,Yu Y,Nakamura K,Koike T,Waqar AB,Zhang X,Liu E,Nishijima K,Kitajima S,Shiomi M,Qi Z,Yu J,Graham MJ,Crooke RM,Ishida T,Hirata K,Hurt-Camejo E,Chen YE,Fan J

更新日期：2012-01-01 00:00:00

abstract：:The plasma levels of blood coagulation and fibrinolytic factors and the serum levels of lipids were measured in 62 subjects (22 normolipidemia and 40 hyperlipidemia) to investigate whether hyperlipidemia may affect the hemostatic system. Prothrombin, factors VII, IX and X were elevated in hyperlipidemic patients. The ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Morishita E,Jokaji H,Matsuda T

更新日期：1995-01-01 00:00:00

abstract：AIMS:The clinical implications of stiffness of the carotid artery (CA) have not been fully clarified in the prediction of coronary artery disease (CAD), although intima-media thickness (IMT) has been established as a surrogate marker. We examined the associations of stiffness parameter beta (ST) and IMT with concurrent...

journal_title：Journal of atherosclerosis and thrombosis

authors： Lee E,Emoto M,Teramura M,Tsuchikura S,Ueno H,Shinohara K,Morioka T,Mori K,Koyama H,Shoji T,Okuno Y,Inaba M,Nishizawa Y

更新日期：2009-03-01 00:00:00

abstract：:Hypertriglyceridemia is often associated with small dense low density lipoprotein (LDL), elevated remnants, and decreased high density lipoprotein (HDL)-cholesterol (C), which comprise the dyslipidemic triad. The objective of this study was to investigate the effect of fenofibrate on the lipoprotein subfraction profil...

journal_title：Journal of atherosclerosis and thrombosis

authors： Ikewaki K,Tohyama J,Nakata Y,Wakikawa T,Kido T,Mochizuki S

更新日期：2004-01-01 00:00:00

abstract：AIM:Asymmetric dimethylarginine(ADMA) has recently been investigated as a risk marker for cardio- and cerebrovascular diseases. However, it is not currently known whether the ADMA levels are related to the risk of stroke in Japanese women. METHODS:We examined 192 Japanese women(mean age, 55±9 years, range, 40-80 years...

journal_title：Journal of atherosclerosis and thrombosis

authors： Muraga K,Nishiyama Y,Otsuka T,Ueda M,Abe A,Katayama Y

更新日期：2014-01-01 00:00:00

abstract：AIM:Lipoprotein lipase protein exists in preheparin serum (preheparin LpL mass), even though lipoprotein lipase activity is rarely detected. Recent clinical studies have clarified that low preheparin LpL mass concentration is an important coronary risk factor. The aim of this study was to clarify the effect of telmisar...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hitsumoto T,Takahashi M,Iizuka T,Shirai K

更新日期：2008-06-01 00:00:00

abstract：AIM:Epicardial adipose tissue (EAT) has been suggested as a contributing factor for coronary atherosclerosis based on the previous cross-sectional studies and pathophysiologic background. However, a causal relationship between EAT and the development of non-calcified coronary plaque (NCP) has not been investigated. ME...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hwang IC,Park HE,Choi SY

更新日期：2017-03-01 00:00:00

abstract：AIM:Endothelial dysfunction is considered an early event in the development of atherosclerosis. The present study was undertaken to determine whether the accumulation of cardiovascular risk factors and insulin resistance are associated with endothelial function in diabetic patients. METHODS:101 patients with type 2 di...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tsuchiya K,Nakayama C,Iwashima F,Sakai H,Izumiyama H,Doi M,Hirata Y

更新日期：2007-12-01 00:00:00

abstract：:Oxidative stress induced by reactive oxygen species (ROS) plays an important role in atherogenesis, and the redox state is determined by the balance between antioxidants and the ROS generating system. To defend against enhanced ROS, mammalian cells have a complex network of antioxidant enzymes such as superoxide dismu...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kobayashi S,Inoue N,Azumi H,Seno T,Hirata K,Kawashima S,Hayashi Y,Itoh H,Yokozaki H,Yokoyama M

更新日期：2002-01-01 00:00:00

abstract：AIM:To study atherosclerosis risk in diabetes, we investigated ATP-binding cassette transporter A1 (ABCA1) expression and high-density lipoprotein (HDL) biogenesis in the liver and hepatocytes under hyperglycemic conditions. METHODS AND RESULTS:In streptozotocin-induced diabetic mice, plasma HDL decreased while ABCA1 ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tsujita M,Hossain MA,Lu R,Tsuboi T,Okumura-Noji K,Yokoyama S

更新日期：2017-11-01 00:00:00

abstract：AIM:All health insurers in Japan are mandated to provide Specific Health Checkups and Specific Health Guidance (SHG) focusing on metabolic syndrome (MetS) in middle-aged adults, beginning in 2008; intensive HG for individuals who have abdominal obesity and two or more additional MetS risk factors, and motivational HG f...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tsushita K,S Hosler A,Miura K,Ito Y,Fukuda T,Kitamura A,Tatara K

更新日期：2018-04-01 00:00:00

abstract：AIM:Although distal embolization during percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) deteriorates cardiac function, whether distal protection (DP) can improve prognosis is still controversial. We investigated whether a filter-type DP device, Filtrap®, could improve long-term outcomes a...

journal_title：Journal of atherosclerosis and thrombosis

authors： Teramoto R,Sakata K,Miwa K,Matsubara T,Yasuda T,Inoue M,Okada H,Kanaya H,Kawashiri MA,Yamagishi M,Hayashi K

更新日期：2016-12-01 00:00:00

abstract：:Calcium deposits account for most of the dry weight of atherosclerotic lesions. Previously considered uncommon, vascular calcification is now known to be present in 80% of significant lesions and in at least 90% of patients with coronary artery disease. Previously considered a passive process, it is increasingly recog...

journal_title：Journal of atherosclerosis and thrombosis

authors： Parhami F,Boström K,Watson K,Demer LL

更新日期：1996-01-01 00:00:00