Effect of statin therapy on the progression of common carotid artery intima-media thickness: an updated systematic review and meta-analysis of randomized controlled trials.

Abstract:

AIM:To evaluate the effect of statin therapy on the decrease of common carotid artery intima-media thickness (CCA-IMT) compared to placebo or usual care. METHODS:A systematic search of electronic databases (MEDLINE, EMBASE, and Cochrane Center Register) up to December 2011 was performed. Two reviewers independently determined the eligibility of randomized controlled trials (RCTs) comparing statin therapy with a placebo or usual care with a minimum follow-up of 6 months. RESULTS:Twenty-one RCTs involving 6317 individuals were included in this review. The pooled weighted mean difference (WMD) between statin therapy and placebo or usual care on CCA-IMT was -0.029 mm (95%CI: -0.045, -0.013). Subgroup analyses showed significant effects of lovastatin (WMD: -0.077; 95%CI: -0.082, -0.073) and simvastatin (WMD: -0.069; 95%CI: -0.094, -0.045), followed by pravastatin and rosuvastatin, but no significant benefits of atorvastatin, fluvastatin, or cerivastatin. A greater decrease in mean CCA-IMT was observed in the setting of secondary prevention versus primary prevention (WMD: -0.045 vs. -0.004), in younger patients versus older patients (WMD: -0.057 vs. -0.041), and in studies where the patient proportion was males ≥ females (-0.044 vs. -0.008). Meta-regression analysis showed a significant association between changes in mean CCA-IMT with decreasing triglyceride levels. A similar, but not statistically significant trend was also found between CCA-IMT decrease and the decrease in LDL-C levels or increase in HDL-C levels. CONCLUSION:Statin therapy is associated with a favorable decrease in CCA-IMT, an effect that seems to be mainly driven by the CCA-IMT at baseline and the extent of lipid decrease, specifically triglycerides.

journal_name

J Atheroscler Thromb

authors

Huang Y,Li W,Dong L,Li R,Wu Y

doi

10.5551/jat.14001

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

108-21

issue

1

eissn

1340-3478

issn

1880-3873

pii

DN/JST.JSTAGE/jat/14001

journal_volume

20

pub_type

杂志文章,meta分析
  • Endothelial lipase mediates HDL levels in normal and hyperlipidemic rabbits.

    abstract:AIM:Existing evidence suggests that endothelial lipase (EL) plays an important role in high-densitylipoprotein (HDL) metabolism. Because rabbits are a useful animal model for the study of human lipid metabolism and atherosclerosis, we characterized rabbit EL (rEL) expression and investigated its relationship with plasm...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.11148

    authors: Zhang J,Yu Y,Nakamura K,Koike T,Waqar AB,Zhang X,Liu E,Nishijima K,Kitajima S,Shiomi M,Qi Z,Yu J,Graham MJ,Crooke RM,Ishida T,Hirata K,Hurt-Camejo E,Chen YE,Fan J

    更新日期:2012-01-01 00:00:00

  • Serum lipid survey and its recent trend in the general Japanese population in 2000.

    abstract::To determine the recent serum lipid levels and other serum variables in the general Japanese population and trends in their changes over the past 40 years, a nationwide survey of serum lipid levels was conducted in 36 institutes from various districts around Japan in 2000. The total number of subjects was 12,839, aged...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,多中心研究

    doi:10.5551/jat.12.98

    authors: Arai H,Yamamoto A,Matsuzawa Y,Saito Y,Yamada N,Oikawa S,Mabuchi H,Teramoto T,Sasaki J,Nakaya N,Itakura H,Ishikawa Y,Ouchi Y,Horibe H,Kita T

    更新日期:2005-01-01 00:00:00

  • Clinical impact of the leptin to soluble leptin receptor ratio on subclinical carotid atherosclerosis in patients with type 2 diabetes.

    abstract:AIM:The adipocyte-derived hormone leptin plays a key role in the regulation of food intake and energy expenditure. Recent studies have suggested that leptin is also involved in the pathogenesis of obesity-associated atherosclerosis and cardiovascular disease. In this study, we investigated the associations of leptin an...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.14662

    authors: Yamazaki Y,Emoto M,Morioka T,Kawano N,Lee E,Urata H,Tsuchikura S,Motoyama K,Mori K,Fukumoto S,Shoji T,Nishizawa Y,Inaba M

    更新日期:2013-01-01 00:00:00

  • Intracoronary infusion of mononuclear bone marrow-derived stem cells is associated with a lower plaque burden after four years.

    abstract:AIM:To assess the long-term effects of intracoronary stem cell (SC) infusion following acute myocardial infarction (AMI) on the local atherosclerotic process at the site of infusion after four years of follow-up. METHODS:We evaluated 18 post-AMI patients. Group 1 consisted of nine patients given an intracoronary injec...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.19745

    authors: Benedek I,Bucur O,Benedek T

    更新日期:2014-01-01 00:00:00

  • Simvastatin, a potent HMG-CoA reductase inhibitor, inhibits the proliferation of human and bovine endothelial cells in vitro.

    abstract::We investigated in vitro effect of simvastatin, a potent 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on the proliferation of human and bovine endothelial cells (EC) compared to that of bovine smooth muscle cells (SMC). Cells were cultured in a medium supplemented with 10% normal serum (FBS). S...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat1994.4.102

    authors: Sato I,Ma L,Ikeda M,Morita I,Murota S

    更新日期:1998-01-01 00:00:00

  • Effects of an HMG-CoA reductase inhibitor, pravastatin, and bile sequestering resin, cholestyramine, on plasma plant sterol levels in hypercholesterolemic subjects.

    abstract::To study exogenous sterol metabolism during the suppression or stimulation of cholesterol biosynthesis induced by treatments for hyperlipidemia, we determined plasma plant sterol concentrations before and after administration of an HMG-CoA reductase inhibitor, pravastatin, and compared these with changes in these plas...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat1994.2.60

    authors: Hidaka H,Kojima H,Kawabata T,Nakamura T,Konaka K,Kashiwagi A,Kikkawa R,Shigeta Y

    更新日期:1995-01-01 00:00:00

  • HDL2/HDL3 Ratio Changes, Metabolic Syndrome Markers, and Other Factors in a Japanese Population.

    abstract:AIM AND METHODS:The high-density lipoprotein 2 cholesterol (HDL2-C) to HDL3-C ratio is associated with insulin resistance, high-molecular-weight adiponectin (HMW-Ad), and metabolic syndrome (MetS) components and is useful for evaluating MetS in Japanese individuals. We investigated potential associations between change...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.32896

    authors: Moriyama K,Takahashi E

    更新日期:2016-06-01 00:00:00

  • Assessing Impact of High-Dose Pitavastatin on Carotid Artery Elasticity with Speckle-Tracking Strain Imaging.

    abstract:AIM:Speckle-tracking imaging has been introduced for the precise assessment of vessel mechanics. However, there are no data on the role of this imaging tool in assessing the changes in vasculature with statin therapy, which is known to enhance vascular elasticity. METHODS:This study was a prospective study including 4...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.42861

    authors: Hae Kim C,Wang S,Park JB,Jung KH,E Yoon Y,Lee SP,Kim HK,Kim YJ,Cho GY,Sohn DW

    更新日期:2018-11-01 00:00:00

  • A case of severe hyperlipidemia caused by long-term tube feedings.

    abstract::A 77-year-old woman with type II diabetes mellitus was admitted to our hospital in August/ 1995 with severe hyperlipidemia. She had taken feedings through a nasogastric tube with 1000 ml (1000 kcal) of Ensureliquid daily since 1993 because of the muscle weakness after rhabdomyolysis. Her serum total cholesterol was 51...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.10.321

    authors: Tanaka S,Miki T,Hsieh ST,Kim JI,Yasumoto T,Taniguchi T,Ishikawa Y,Yokoyama M

    更新日期:2003-01-01 00:00:00

  • Can intensive lipid-lowering therapy with statins ameliorate atherosclerosis in Japanese patients? Rationale and design of the JART study.

    abstract:AIM:In Japan, heart disease and cerebral ischemic disease are major causes of death. A decrease in the level of low-density lipoprotein cholesterol (LDL-C) through intensive treatment with statins positively correlates with a reduction in the volume of plaques in patients with cardiovascular disease. The METEOR trial, ...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.5551/jat.2899

    authors: Kurabayashi M,Sakuma I,Kawamori R,Daida H,Yamazaki T,Yoshida M,Hata M,Masuda I,Kaku K,Yokoi H,Kishimoto J,Nohara R

    更新日期:2010-04-30 00:00:00

  • Elevation of plasma lipid peroxides in non-insulin dependent diabetics with multiple lacunar infarcts.

    abstract::Our purpose was to determine whether lipid peroxides are elevated in the plasma of patients with non-insulin dependent diabetes with multiple lacunar infarcts as detected by magnetic resonance imaging (MRI), and to confirm whether peroxide levels correlate with glycemic controls and blood lipid levels. The level of li...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat1994.4.90

    authors: Fujiwara Y,Nishihara H,Nakakoshi T,Hasegawa T,Tagami S,Kawakami Y

    更新日期:1997-01-01 00:00:00

  • Current therapy for patients with sitosterolemia--effect of ezetimibe on plant sterol metabolism.

    abstract::Sitosterolemia is a rare, autosomal recessive inherited sterol storage disease associated with high tissue and serum plant sterol concentrations, caused by mutations in the adenosine triphosphate-bind-ing cassette (ABC) transporter ABCG5 or ABCG8 genes. Markedly increased serum concentration of plant sterols. such as ...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,评审

    doi:10.5551/jat.4614

    authors: Tsubakio-Yamamoto K,Nishida M,Nakagawa-Toyama Y,Masuda D,Ohama T,Yamashita S

    更新日期:2010-09-30 00:00:00

  • Epoxyeicosatrienoic Acids are Mediated by EPHX2 Variants and may be a Predictor of Early Neurological Deterioration in Acute Minor Ischemic Stroke.

    abstract:AIM:To investigatethe association of plasma epoxyeicosatrienoic acids (EETs) with early neurologic deterioration (END), and whether EETs are mediated by EPHX2 variants in patients with minor ischemic stroke (MIS). METHOD:This was a prospective, multi-center observational study in patients with acute MIS in the Chinese...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,多中心研究

    doi:10.5551/jat.41145

    authors: Yi X,Lin J,Li J,Zhou Q,Han Z

    更新日期:2017-12-01 00:00:00

  • Bilirubin and Endothelial Function.

    abstract::Bilirubin is a fundamental metabolic end product of heme degradation. Despite acting as a cytotoxic metabolite at high concentrations, bilirubin at physiological concentrations has antioxidant effects, such as scavenging reactive oxygen species, leading to a decrease in oxidative stress. Endothelial dysfunction is an ...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,评审

    doi:10.5551/jat.RV17035

    authors: Maruhashi T,Kihara Y,Higashi Y

    更新日期:2019-08-01 00:00:00

  • Cardiorespiratory Fitness is a Strong Predictor of the Cardio-ankle Vascular Index in Hypertensive Middle-aged and Elderly Japanese Men.

    abstract:AIM:This study aimed to examine whether cardiorespiratory fitness (CRF) is associated with arterial stiffening, evaluated using the cardio-ankle vascular index (CAVI), independent of visceral fat (VF) in middle-aged and elderly Japanese men. We also examined whether the relationship between CRF and the CAVI is modified...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.25098

    authors: Tanisawa K,Ito T,Sun X,Kawakami R,Oshima S,Gando Y,Cao ZB,Sakamoto S,Higuchi M

    更新日期:2015-01-01 00:00:00

  • Examination of Large Artery Atherosclerosis could Reveal Small Artery Retinopathy in Untreated Middle-Aged Individuals.

    abstract:AIMS:Small arteries can be visualized in the ocular fundus, and findings of retinopathy based on Scheie classification are often applied to evaluate the impact of hypertension and atherosclerosis. However, the relationship between damage in the large and small arteries has not been investigated sufficiently, especially...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.59857

    authors: Sugiura T,Dohi Y,Takagi Y,Yokochi T,Yoshikane N,Suzuki K,Tomiishi T,Nagami T,Iwase M,Takase H,Seo Y,Ohte N

    更新日期:2020-11-25 00:00:00

  • Mild Hyperbaric Oxygen Inhibits Growth-related Decrease in Muscle Oxidative Capacity of Rats with Metabolic Syndrome.

    abstract:AIM:We examined the effects of mild hyperbaric oxygen on the properties of the soleus muscle in rats with metabolic syndrome. METHODS:Five-week-old metabolic syndrome (SHR/NDmcr-cp, cp/cp) rats were divided into normobaric (CP) and mild hyperbaric oxygen (CP-H) groups (n=5/group). In addition, 5-week-old Wistar rats w...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.34686

    authors: Takemura A,Ishihara A

    更新日期:2017-01-01 00:00:00

  • Long-term exposure to particulate matter in relation to mortality and incidence of cardiovascular disease: the JPHC Study.

    abstract:AIM:Associations between long-term exposure to particulate matter (PM) and increased cardiovascular mortality have been reported, but few studies have investigated the associated incidence of cardiovascular disease, and none involved men. METHODS:We used data on 78,057 participants (37,121 men, 40,936 women) to examin...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.15347

    authors: Nishiwaki Y,Michikawa T,Takebayashi T,Nitta H,Iso H,Inoue M,Tsugane S,Japan Public Health Center-based Prospective Study Group.

    更新日期:2013-01-01 00:00:00

  • Small dense LDL enhances THP-1 macrophage foam cell formation.

    abstract:AIM:Increased levels of small dense low-density lipoproteins (sd-LDL) have been reported more atherogenic compared to total low-density lipoprotein (LDL); however, no definitive experiments using macrophages have examined this concept in vitro. METHOD AND RESULT:In this study, we isolated fractions of total LDL (densi...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.7161

    authors: Tani M,Kawakami A,Mizuno Y,Imase R,Ito Y,Kondo K,Ishii H,Yoshida M

    更新日期:2011-01-01 00:00:00

  • Plasma NOx concentrations in glucose intolerance and type 2 diabetes. A case-control study in a Vietnamese population.

    abstract:AIM:The Vietnamese develop type 2 diabetes (T2D) and metabolic syndrome (MS) at a lower BMI than other ethnicities. Thus, biomarkers that identify subjects at an increased risk of T2D independently of obesity are being sought. Recent studies show that circulating NO metabolites (NOx) are increased in T2D. We investigat...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.7393

    authors: Binh PN,Abe Y,Tien PG,Son le NT,Hanh TT,Diep do TN,Qui le TK,Kawano M,Maruyama C

    更新日期:2011-01-01 00:00:00

  • Effect of Metabolically Healthy Obesity on the Development of Carotid Plaque in the General Population: A Community-Based Cohort Study.

    abstract:AIM:Obesity and metabolic syndrome (MetS) frequently coexist and are both important risk factors for cardiovascular disease. However, the pathophysiological role of obesity without MetS, also referred to as metabolically healthy obesity (MHO), remains unclear. In this study, we aim to clarify the effect of MHO on the d...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.48728

    authors: Itoh H,Kaneko H,Kiriyama H,Yoshida Y,Nakanishi K,Mizuno Y,Daimon M,Morita H,Yatomi Y,Yamamichi N,Komuro I

    更新日期:2020-02-01 00:00:00

  • Awareness and Prophylaxis of Venous Thromboembolism in Patients with COVID-19: A National Cross-Sectional Survey in Epidemic Era.

    abstract:AIM:Patients with acute infectious diseases are at an increased risk of venous thromboembolism (VTE). Clinicians should be aware of the VTE risk in patients with COVID-19, many of whom present with severe coagulation disorders. METHOD:We used an online platform to conduct a cross-sectional questionnaire survey among d...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.58933

    authors: Zhang Z,Xi L,Zhang S,Zhang Y,Pang W,Wang Y,Li C,Zhai Z,Wang C

    更新日期:2020-10-01 00:00:00

  • Five-Year Patency and its Predictors after Endovascular Therapy for Aortoiliac Occlusive Disease.

    abstract:AIM:Although current guidelines recommend surgical revascularization as the first-line therapy for chronic total occlusion of the abdominal aorta (Leriche syndrome), endovascular therapy (EVT) has been increasingly utilized because of the development of new technologies and techniques. EVT has demonstrated durable midt...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,多中心研究

    doi:10.5551/jat.45617

    authors: Nanto K,Iida O,Fujihara M,Yokoi Y,Tomoi Y,Soga Y,Fujita M,Masuda M,Okamoto S,Ishihara T,Kanda T,Tsujimura T,Matsuda Y,Okuno S,Mano T

    更新日期:2019-11-01 00:00:00

  • Oxysterol-induced apoptosis of vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitor, pravastatin.

    abstract::We investigated the mechanism by which 7-ketocholesterol damages vascular smooth muscle cells and the protective effect of the hydroxymethyl glutary CoA reductase inhibitor, pravastatin on it. When 7-ketocholesterol (50 micromol/L) was added to cultured human vascular smooth muscle cells, the extent of cell detachment...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.9.65

    authors: Miyashita Y,Ozaki H,Koide N,Otsuka M,Oyama T,Itoh Y,Mastuzaka T,Shirai K

    更新日期:2002-01-01 00:00:00

  • Development of atherosclerosis in alloxan diabetic rats.

    abstract::Rats with alloxan-induced diabetes developed severe atherosclerotic lesions when they were maintained on a 0.25% cholesterol diet for one year. The atheromatous changes developed at the aortic arch, appeared as early as 3 months after the start of the experiment, and increased thereafter. The diabetic rats also develo...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat1994.1.118

    authors: Uchida K,Takase H,Nomura Y,Nakamura Y,Igimi H,Takasu N,Kurihara H,Takeuchi N

    更新日期:1994-01-01 00:00:00

  • Relationships between nocturnal intermittent hypoxia, arterial stiffness and cardiovascular risk factors in a community-based population: the Toon health study.

    abstract:AIM:Nocturnal intermittent hypoxia (NIH), a primary marker of obstructive sleep apnea, has increasingly been linked with cardiovascular morbidity and mortality. The purpose of this study was to investigate the association between NIH and arterial stiffness as measured according to the cardio-ankle vascular index (CAVI)...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.24505

    authors: Alberto EC,Tanigawa T,Maruyama K,Kawasaki Y,Eguchi E,Mori H,Yoshimura K,Tanno S,Sakurai S,Hitsumoto S,Saito I

    更新日期:2014-01-01 00:00:00

  • Involvement of vascular angiotensin II-forming enzymes in the progression of aortic abdominal aneurysms in angiotensin II- infused ApoE-deficient mice.

    abstract:AIM:Angiotensin (Ang) II-induced abdominal aortic aneurysm (AAA) in apoE-deficient mice has been used as a model of human AAA, but it has been unclear why the progression of AAA continues after stopping the Ang II infusion. The involvement of vascular Ang II-forming enzymes in the progression of AAA was studied. METHO...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.e611

    authors: Inoue N,Muramatsu M,Jin D,Takai S,Hayashi T,Katayama H,Kitaura Y,Tamai H,Miyazaki M

    更新日期:2009-06-01 00:00:00

  • Vascular Function and Intima-media Thickness of a Leg Artery in Peripheral Artery Disease: A Comparison of Buerger Disease and Atherosclerotic Peripheral Artery Disease.

    abstract:AIM:Both vascular function and structure are independent predictors of cardiovascular events. The purpose of this study was to evaluate vascular function and structure of a leg artery in patients with peripheral artery disease (PAD). METHODS:We measured flow-mediated vasodilatation (FMD) and nitroglycerine-induced vas...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.35436

    authors: Iwamoto A,Kajikawa M,Maruhashi T,Iwamoto Y,Oda N,Kishimoto S,Matsui S,Kihara Y,Chayama K,Goto C,Noma K,Aibara Y,Nakashima A,Higashi Y

    更新日期:2016-11-01 00:00:00

  • TGF-beta1 up-regulates expression of ABCA1, ABCG1 and SR-BI through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells.

    abstract:AIM:High density lipoprotein (HDL) and its apolipoproteins can promote cholesterol efflux from macrophage foam cells via the ATP-binding cassette transporter A1 (ABCA1), ABCG1, and scavenger receptor class B type I (SR-BI). Liver X receptors (LXRs) operate as cholesterol sensors which may protect from cholesterol overl...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.3152

    authors: Hu YW,Wang Q,Ma X,Li XX,Liu XH,Xiao J,Liao DF,Xiang J,Tang CK

    更新日期:2010-05-01 00:00:00

  • Nutritional Status is Associated with Inflammation and Predicts a Poor Outcome in Patients with Chronic Heart Failure.

    abstract:AIM:Malnutrition has been identified to be an independent predictor of morbidity and mortality in patients with chronic heart failure (CHF). However, the pathophysiological mechanisms underlying this pathway remain unclear. METHODS:Nutritional screening was performed using the controlling nutritional status (CONUT) sc...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.31526

    authors: Nakagomi A,Kohashi K,Morisawa T,Kosugi M,Endoh I,Kusama Y,Atarashi H,Shimizu W

    更新日期:2016-06-01 00:00:00