Hyperlipidemia and hemostatic system.

Abstract:

:The plasma levels of blood coagulation and fibrinolytic factors and the serum levels of lipids were measured in 62 subjects (22 normolipidemia and 40 hyperlipidemia) to investigate whether hyperlipidemia may affect the hemostatic system. Prothrombin, factors VII, IX and X were elevated in hyperlipidemic patients. The positive correlations were found between factors VII, IX and X, and triglyceride. The significant correlations were also found between VII and IX, and total cholesterol. Plasma levels of thrombin-antithrombin III complex (TAT), which reflects activation of coagulation system, were slightly but significantly higher in type IIb hyperlipidemia, although they were within normal range. Plasma levels of active plasminogen activator inhibitor (PAI) in type IIb and IV were significantly higher than in normals. A significant correlation was found between active PAI and triglyceride (r = 0.76, p < 0.0001). After the administration of fat emulsion to 18 patients with various diseases, which induced artificial hypertriglyceridemia, PAI levels as well as triglyceride levels significantly increased. These results suggest that hypertriglyceridemia may increase the synthesis and/or release of PAI, inducing a hypofibrinolytic condition, which could lead to thrombosis. It has been established that lipoprotein (a) [Lp(a)], which has a molecular structure homology to plasminogen, impairs fibrinolysis by its competitive inhibition of adsorption of plasminogen to vascular endothelial surface and/or fibrin. We assayed plasma levels of Lp(a) and parameters of blood coagulation and fibrinolysis in 168 patients with type II diabetes mellitus and 48 normal controls. In the diabetics, the levels of Lp(a) as well as levels of tissue-type plasminogen activator (t-PA) antigen and PAI activity were significantly higher than normal controls. Furthermore, it was shown that Lp(a) had a weakly negative correlation with t-PA antigen in the diabetics. These results suggest that an elevated level of Lp(a) may decrease release of t-PA, although the underlying mechanism remains unsolved.

journal_name

J Atheroscler Thromb

authors

Morishita E,Jokaji H,Matsuda T

doi

10.5551/jat1994.2.supplement1_s36

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

S36-40

eissn

1340-3478

issn

1880-3873

journal_volume

2 Suppl 1

pub_type

杂志文章
  • Five-Year Patency and its Predictors after Endovascular Therapy for Aortoiliac Occlusive Disease.

    abstract:AIM:Although current guidelines recommend surgical revascularization as the first-line therapy for chronic total occlusion of the abdominal aorta (Leriche syndrome), endovascular therapy (EVT) has been increasingly utilized because of the development of new technologies and techniques. EVT has demonstrated durable midt...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,多中心研究

    doi:10.5551/jat.45617

    authors: Nanto K,Iida O,Fujihara M,Yokoi Y,Tomoi Y,Soga Y,Fujita M,Masuda M,Okamoto S,Ishihara T,Kanda T,Tsujimura T,Matsuda Y,Okuno S,Mano T

    更新日期:2019-11-01 00:00:00

  • Hepatic Control of Energy Metabolism via the Autonomic Nervous System.

    abstract::Although the human liver comprises approximately 2.8% of the body weight, it plays a central role in the control of energy metabolism. While the biochemistry of energy substrates such as glucose, fatty acids, and ketone bodies in the liver is well understood, many aspects of the overall control system for hepatic meta...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,评审

    doi:10.5551/jat.RV16002

    authors: Yahagi N

    更新日期:2017-01-01 00:00:00

  • Effects of pitavastatin (LIVALO tablet) on the estimated glomerular filtration rate (eGFR) in hypercholesterolemic patients with chronic kidney disease. Sub-analysis of the LIVALO Effectiveness and Safety (LIVES) Study.

    abstract:AIM:In addition to the risk of progression to end-stage renal disease (ESRD), chronic kidney disease (CKD) is also known to be associated with an elevated risk of cardiovascular disease (CVD). Statins may improve renal function in CKD patients. METHODS:The database of the LIVALO Effectiveness and Safety (LIVES) Study,...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.3764

    authors: Kimura K,Shimano H,Yokote K,Urashima M,Teramoto T

    更新日期:2010-06-30 00:00:00

  • Circulating adiponectin levels and their associated factors in young lean healthy Japanese women.

    abstract:AIM:The aim of the current study was to investigate circulating adiponectin levels and their associated factors in young lean healthy Japanese women. METHODS:We recruited 82 healthy Japanese women in their twenties and thirties with their body mass index <25 kg/m(2), and performed anthropometric, sphygmomanometric, an...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.14357

    authors: Takahara M,Katakami N,Kishida K,Kaneto H,Funahashi T,Shimomura I,Matsunaga S,Kubo S,Fukamizu H,Otsuka A,Ichihara K,Nakamura T

    更新日期:2013-01-01 00:00:00

  • Investigation of Obstructive Sleep Apnea Using Portable Monitors and Health Check Data in Japanese Drivers.

    abstract:AIMS:The identification and appropriate management of commercial motor vehicle (CMV) drivers with unrecognized obstructive sleep apnea (OSA) is a major public health concern and priority; OSA among drivers has not been fully investigated in Japan, and a better understanding of this undiagnosed disease is warranted. The...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.41806

    authors: Ueyama M,Kokuto H,Sugihara H,Oikawa S,Suzuki F,Goto H,Kudoh S

    更新日期:2018-11-01 00:00:00

  • Progression of Carotid Atherosclerosis in Two Japanese Populations with Different Lifestyles.

    abstract:AIM:We have conducted medical surveys on two Japanese populations (Japanese Americans living in the US and native Japanese living in Japan) to investigate the impact of westernization of lifestyles on diseases in Japanese people. A 1998 survey revealed that the progression of carotid intima-media wall thickness (IMT) w...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.39578

    authors: Kubota M,Yoneda M,Watanabe H,Egusa G

    更新日期:2017-10-01 00:00:00

  • Assessing Impact of High-Dose Pitavastatin on Carotid Artery Elasticity with Speckle-Tracking Strain Imaging.

    abstract:AIM:Speckle-tracking imaging has been introduced for the precise assessment of vessel mechanics. However, there are no data on the role of this imaging tool in assessing the changes in vasculature with statin therapy, which is known to enhance vascular elasticity. METHODS:This study was a prospective study including 4...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.42861

    authors: Hae Kim C,Wang S,Park JB,Jung KH,E Yoon Y,Lee SP,Kim HK,Kim YJ,Cho GY,Sohn DW

    更新日期:2018-11-01 00:00:00

  • The History of the WHHL Rabbit, an Animal Model of Familial Hypercholesterolemia (II) - Contribution to the Development and Validation of the Therapeutics for Hypercholesterolemia and Atherosclerosis.

    abstract::A number of effective drugs have been developed through animal experiments, contributing to the health of many patients. In particular, the WHHL rabbit family (WHHL rabbits and its advanced strains (coronary atherosclerosis-prone WHHL-CA rabbits and myocardial infarction-prone WHHLMI rabbits) developed at Kobe Univers...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 历史文章,杂志文章

    doi:10.5551/jat.RV17038-2

    authors: Shiomi M

    更新日期:2020-02-01 00:00:00

  • Association between renal vasculature changes and generalized atherosclerosis: an autopsy survey.

    abstract:AIM:To examine the association between renal vasculature changes and generalized atherosclerosis using autopsy cases. METHODS:We histologically examined 107 autopsy patients(mean age, 68.4 years; 64% men; 81% non-CVD) to investigate the association between renal vasculature changes and generalized atherosclerosis. We ...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.19869

    authors: Iwakiri T,Sato Y,Matsuura Y,Hatakeyama K,Marutsuka K,Yamashita A,Fujimoto S,Kitamura K,Asada Y

    更新日期:2014-01-01 00:00:00

  • Zetia: inhibition of Niemann-Pick C1 Like 1 (NPC1L1) to reduce intestinal cholesterol absorption and treat hyperlipidemia.

    abstract::Zetia (ezetimibe) is a selective cholesterol absorption inhibitor, which potently inhibits the absorption of biliary and dietary cholesterol from the small intestine without affecting the absorption of fat-soluble vitamins, triglycerides or bile acids. Ezetimibe reduces the small intestinal enterocyte uptake and absor...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,评审

    doi:10.5551/jat.14.99

    authors: Davis HR,Veltri EP

    更新日期:2007-06-01 00:00:00

  • Lipid Lowering Therapy to Modify Plaque Microstructures.

    abstract::Due to the pandemics of obesity and diabetes mellitus, especially in the Western countries, atherosclerotic cardiovascular disease (ASCVD) has become a major health burden and is expected to increase in the future. Modifying lipid targets, especially low-density lipoprotein cholesterol (LDL-C) level, has become the fi...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,评审

    doi:10.5551/jat.RV16009

    authors: Kataoka Y,Andrews J,Puri R,Psaltis P,Nicholls SJ

    更新日期:2017-04-03 00:00:00

  • Association of Total Energy Intake with 29-Year Mortality in the Japanese: NIPPON DATA80.

    abstract:AIM:In animals, dietary energy restriction is reported to increase longevity, whereas in humans, all cohort studies from Western countries have not shown an association between the low energy intake and longevity. We examined the association between total energy intake and longevity in Japan where dietary pattern is di...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.29991

    authors: Nagai M,Ohkubo T,Miura K,Fujiyoshi A,Okuda N,Hayakawa T,Yoshita K,Arai Y,Nakagawa H,Nakamura K,Miyagawa N,Takashima N,Kadota A,Murakami Y,Nakamura Y,Abbott RD,Okamura T,Okayama A,Ueshima H,NIPPON DATA80 Research Gro

    更新日期:2016-01-01 00:00:00

  • Expression of perilipin and adipophilin in nonalcoholic fatty liver disease; relevance to oxidative injury and hepatocyte ballooning.

    abstract:AIMS:Perilipin and adipophilin, PAT family proteins, play important roles in lipid metabolism. Although nonalcoholic fatty liver disease (NAFLD) is initiated by hepatocyte lipidation, little is known about the relationship between these proteins and hepatocellular injury. We investigated the expressions of perilipin an...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.2055

    authors: Fujii H,Ikura Y,Arimoto J,Sugioka K,Iezzoni JC,Park SH,Naruko T,Itabe H,Kawada N,Caldwell SH,Ueda M

    更新日期:2009-01-01 00:00:00

  • Associations between plasma C-reactive protein levels and the severities of coronary and aortic atherosclerosis.

    abstract:AIM:Limited correlations between C-reactive protein (CRP) and coronary artery disease (CAD) have been reported. Recently, MRI became a useful tool for non-invasively evaluating atherosclerotic plaques in thoracic and abdominal aortas. METHODS:To elucidate the associations between plasma CRP levels and the severities o...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.2931

    authors: Momiyama Y,Ohmori R,Fayad ZA,Kihara T,Tanaka N,Kato R,Taniguchi H,Nagata M,Nakamura H,Ohsuzu F

    更新日期:2010-05-01 00:00:00

  • C-C chemokine receptor 2 inhibitor improves diet-induced development of insulin resistance and hepatic steatosis in mice.

    abstract:AIM:Adipose tissue inflammation induced by macrophage infiltration through the MCP-1/CCR2 pathway is considered to play a pivotal role in the development of visceral obesity and insulin resistance. In the present study, therefore, we examined whether pharmacological inhibition of CCR2 is effective against the developme...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.3368

    authors: Tamura Y,Sugimoto M,Murayama T,Minami M,Nishikaze Y,Ariyasu H,Akamizu T,Kita T,Yokode M,Arai H

    更新日期:2010-03-31 00:00:00

  • The serum YKL-40 level is associated with vascular injury and predicts proteinuria in nephrotic syndrome patients.

    abstract:AIM:Nephrotic syndrome (NS) is associated with an increased rate of cardiovascular events. The YKL-40 level is associated with atherosclerosis, endothelial dysfunction and proteinuria in renal and non-renal populations. The aim of this study was to investigate the relationships between the YKL-40 level and both vascula...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.26385

    authors: Kocyigit I,Gungor O,Dogan E,Karadavut S,Karakukcu C,Eroglu E,Orscelik O,Unal A,Dogan A,Sipahioglu MH,Tokgoz B,Oymak O

    更新日期:2015-01-01 00:00:00

  • Urinary 8-Hydroxy-2'-Deoxyguanosine Levels and Cardiovascular Disease Incidence in Japan.

    abstract:AIM:The association between urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), an oxidative stress marker, and the incidence of cardiovascular disease (CVD) has not been confirmed because no previous studies evaluated 24-hour 8-OHdG excretion levels in the general population. We aimed to confirm the association between 24-h...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.51664

    authors: Nagao M,Kobashi G,Umesawa M,Cui R,Yamagishi K,Imano H,Okada T,Kiyama M,Kitamura A,Sairenchi T,Haruyama Y,Ohira T,Iso H,CIRCS Investigators.

    更新日期:2020-10-01 00:00:00

  • Oxysterol-induced apoptosis of vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitor, pravastatin.

    abstract::We investigated the mechanism by which 7-ketocholesterol damages vascular smooth muscle cells and the protective effect of the hydroxymethyl glutary CoA reductase inhibitor, pravastatin on it. When 7-ketocholesterol (50 micromol/L) was added to cultured human vascular smooth muscle cells, the extent of cell detachment...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.9.65

    authors: Miyashita Y,Ozaki H,Koide N,Otsuka M,Oyama T,Itoh Y,Mastuzaka T,Shirai K

    更新日期:2002-01-01 00:00:00

  • Clinical impact of the leptin to soluble leptin receptor ratio on subclinical carotid atherosclerosis in patients with type 2 diabetes.

    abstract:AIM:The adipocyte-derived hormone leptin plays a key role in the regulation of food intake and energy expenditure. Recent studies have suggested that leptin is also involved in the pathogenesis of obesity-associated atherosclerosis and cardiovascular disease. In this study, we investigated the associations of leptin an...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.14662

    authors: Yamazaki Y,Emoto M,Morioka T,Kawano N,Lee E,Urata H,Tsuchikura S,Motoyama K,Mori K,Fukumoto S,Shoji T,Nishizawa Y,Inaba M

    更新日期:2013-01-01 00:00:00

  • Relationship between CCL22 Expression by Vascular Smooth Muscle Cells and Macrophage Histamine Receptors in Atherosclerosis.

    abstract:AIM:CCL22, mainly synthesized by monocyte-derived alternative (M2) macrophages, belongs to the CC family of chemokines and is involved in monocyte migration and recruitment. We have previously investigated CCL22 and histamine in atherosclerosis. Here, we investigated the hypothesis that CCL22 is involved in atheroscler...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.44297

    authors: Kimura S,Noguchi H,Nanbu U,Wang KY,Sasaguri Y,Nakayama T

    更新日期:2018-12-01 00:00:00

  • Long-term exposure to particulate matter in relation to mortality and incidence of cardiovascular disease: the JPHC Study.

    abstract:AIM:Associations between long-term exposure to particulate matter (PM) and increased cardiovascular mortality have been reported, but few studies have investigated the associated incidence of cardiovascular disease, and none involved men. METHODS:We used data on 78,057 participants (37,121 men, 40,936 women) to examin...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.15347

    authors: Nishiwaki Y,Michikawa T,Takebayashi T,Nitta H,Iso H,Inoue M,Tsugane S,Japan Public Health Center-based Prospective Study Group.

    更新日期:2013-01-01 00:00:00

  • A rabbit model of spontaneous thrombosis induced by lipopolysaccharide.

    abstract:AIM:Inflammation plays a critical role in the development of atherosclerotic plaque, and lipopolysaccharide (LPS) is a potentially important source of inflammation. The aim of this study was to develop a rabbit model of spontaneous thrombosis mimicking the pathophysiological and morphological characteristics of atheros...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.22772

    authors: Liu H,Hou J,Hu S,Du X,Fang Y,Jia H,Feng L,Zhang L,Du J,Zhao Q,Xie Z,Yu B

    更新日期:2014-01-01 00:00:00

  • Impact of Homocysteine Level on Long-term Cardiovascular Outcomes in Patients after Coronary Artery Stenting.

    abstract:AIM:The prognostic value of homocysteine (HCY) in patients with coronary artery diseases (CAD) is still controversial. The objective of this study was to investigate whether elevated HCY level at admission predict long-term outcomes in patients after percutaneous coronary interventions (PCI) with coronary artery stenti...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 临床试验,杂志文章

    doi:10.5551/jat.36434

    authors: Yeh JK,Chen CC,Hsieh MJ,Tsai ML,Yang CH,Chen DY,Chang SH,Wang CY,Lee CH,Hsieh IC

    更新日期:2017-07-01 00:00:00

  • Effect of the angiotensin II receptor antagonist telmisartan on lipoprotein lipase mass in preheparin serum.

    abstract:AIM:Lipoprotein lipase protein exists in preheparin serum (preheparin LpL mass), even though lipoprotein lipase activity is rarely detected. Recent clinical studies have clarified that low preheparin LpL mass concentration is an important coronary risk factor. The aim of this study was to clarify the effect of telmisar...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.e547

    authors: Hitsumoto T,Takahashi M,Iizuka T,Shirai K

    更新日期:2008-06-01 00:00:00

  • Relationship between Circulating Inflammatory Monocytes and Cardiovascular Disease Measures of Carotid Intimal Thickness.

    abstract:AIMS:Cardiovascular disease (CVD) remains the leading cause of death worldwide despite improvements in the treatment of atherosclerosis, an inflammatory disease and major underlying cause of CVD. Monocytes, an innate immune cell type, are linked to CVD progression; however, given their heterogeneity, the association be...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.49791

    authors: SahBandar IN,Ndhlovu LC,Saiki K,Kohorn LB,Peterson MM,D'Antoni ML,Shiramizu B,Shikuma CM,Chow DC

    更新日期:2020-05-01 00:00:00

  • Inter-Arm Blood Pressure Difference in Diabetes Mellitus and Its Preferential Association with Peripheral Artery Disease.

    abstract:AIM:Inter-arm blood pressure difference (IAD) is known to be associated with a composite of cardiovascular disease (CVD) and with CVD risk factors. However, only limited information is available regarding the contribution of diabetes mellitus to IAD and the association of IAD with individual CVDs, such as coronary arte...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.52886

    authors: Miyashima M,Shoji T,Kakutani Y,Yamazaki Y,Ochi A,Morioka T,Shinohara-Mitsuki K,Fukumoto S,Shioi A,Inaba M,Emoto M

    更新日期:2020-08-01 00:00:00

  • Hormones and arterial stiffness in patients with chronic kidney disease.

    abstract::Cardiovascular disease constitutes the major cause of mortality in patients with chronic kidney disease. Arterial stiffness is an important contributor to the occurrence and progression of cardiovascular disease. Various risk factors, including altered hormone levels, have been suggested to be associated with arterial...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,评审

    doi:10.5551/jat.18580

    authors: Gungor O,Kircelli F,Voroneanu L,Covic A,Ok E

    更新日期:2013-01-01 00:00:00

  • Rationale and Descriptive Analysis of Specific Health Guidance: the Nationwide Lifestyle Intervention Program Targeting Metabolic Syndrome in Japan.

    abstract:AIM:All health insurers in Japan are mandated to provide Specific Health Checkups and Specific Health Guidance (SHG) focusing on metabolic syndrome (MetS) in middle-aged adults, beginning in 2008; intensive HG for individuals who have abdominal obesity and two or more additional MetS risk factors, and motivational HG f...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.42010

    authors: Tsushita K,S Hosler A,Miura K,Ito Y,Fukuda T,Kitamura A,Tatara K

    更新日期:2018-04-01 00:00:00

  • Molecular analysis of a novel LCAT mutation (Gly179 → Arg) found in a patient with complete LCAT deficiency.

    abstract::Lecithin-cholesterol acyltransferase (LCAT) is an important enzyme involved in the esterification of cholesterol. Here, we report a novel point mutation in the LCAT gene of a 63-year-old female with characteristics of classic familial LCAT deficiency. The patient's clinical manifestations included corneal opacity, mil...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.8003

    authors: Wang XL,Osuga J,Tazoe F,Okada K,Nagashima S,Takahashi M,Ohshiro T,Bayasgalan T,Yagyu H,Okada K,Ishibashi S

    更新日期:2011-01-01 00:00:00

  • CD40 ligand and MCP-1 as predictors of cardiovascular events in diabetic patients with stroke.

    abstract:AIM:Up-regulation of soluble CD40 ligand (sCD40L) and of monocyte chemoattractant protein-1 (MCP-1) has been found in diabetes and in patients with acute cerebral ischemia. We asked whether (i) the two molecules are similarly upregulated among non-lacunar and lacunar diabetic strokes and (ii) sCD40L and/or MCP-1 predic...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章

    doi:10.5551/jat.1537

    authors: Davì G,Tuttolomondo A,Santilli F,Basili S,Ferrante E,Di Raimondo D,Pinto A,Licata G

    更新日期:2009-01-01 00:00:00