Abstract:
AIM:Epicardial adipose tissue (EAT) has been suggested as a contributing factor for coronary atherosclerosis based on the previous cross-sectional studies and pathophysiologic background. However, a causal relationship between EAT and the development of non-calcified coronary plaque (NCP) has not been investigated. METHODS:A total of 122 asymptomatic individuals (age, 56.0±7.6 years; male, 80.3%) without prior history of coronary artery disease (CAD) or metabolic syndrome and without NCP or obstructive CAD at baseline cardiac computed tomography (CT) were enrolled. Repeat cardiac CT was performed with an interval of more than 5 years. Epicardial fat volume index (EFVi; cm3/m2) was assessed in relation to the development of NCP on the follow-up CT where the results were classified into "calcified plaque (CP)," "no plaque," and "NCP" groups. RESULTS:On the follow-up CT performed with a median interval of 65.4 months, we observed newly developed NCP in 24 (19.7%) participants. Baseline EFVi was significantly higher in the NCP group (79.9±30.3 cm3/m2) than in the CP group (63.7±22.7 cm3/m2; P=0.019) and in the no plaque group (62.5±24.7 cm3/m2; P=0.021). Multivariable logistic regression analysis demonstrated that the presence of diabetes (OR, 9.081; 95% CI, 1.682-49.034; P=0.010) and the 3rd tertile of EFVi (OR, 4.297; 95% CI, 1.040-17.757; P=0.044 compared to the 1st tertile) were the significant predictors for the development of NCP on follow-up CT. CONCLUSIONS:Greater amount of EAT at baseline CT independently predicts the development of NCP in asymptomatic individuals.
journal_name
J Atheroscler Thrombjournal_title
Journal of atherosclerosis and thrombosisauthors
Hwang IC,Park HE,Choi SYdoi
10.5551/jat.36467subject
Has Abstractpub_date
2017-03-01 00:00:00pages
262-274issue
3eissn
1340-3478issn
1880-3873journal_volume
24pub_type
杂志文章abstract:AIMS:Renal dysfunction is a major public health problem, but there have been few investigations of the relationship between serum high molecular weight (HMW) adiponectin and renal function in Japanese community-dwelling adults. METHODS:We randomly recruited a sample of 1,849 adult Japanese (793 men aged 60 ± 14 (mean ...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,评审
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of atherosclerosis and thrombosis
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