Abstract:
AIM:Glucagon-like peptide-1 can reduce both postprandial plasma glucose (PG) and chylomicron (CM) levels in patients with type 2 diabetes. However, there have been no reports regarding the relationship between the postprandial metabolism of PG and CM. METHODS:Patients with type 2 diabetes who were admitted for glycemic control were randomized to insulin alone (Ins; n=16) or insulin plus vildagliptin 100 mg (InsV; n=16) groups. The insulin dose was adjusted to maintain normal blood glucose levels. The daily profiles of serum TG, remnant lipoprotein cholesterol (RemL-C), and apolipoprotein B48 (ApoB48) were estimated by frequent blood collection on admission and before discharge, and the daily glucose fluctuation profile was also estimated using continuous glucose monitoring (CGM) before discharge. RESULTS:The daily profiles of serum TG and RemL-C indicated a significant decrease before discharge compared with on admission; however, no significant changes in serum ApoB48 levels were observed in either group. At discharge, daily glucose fluctuation profile and the change in the serum ApoB48 level from fasting to the peak of the daily profile was significantly smaller in the InsV group than in the Ins group. The increment of serum ApoB48 level was significantly correlated with the mean amplitude of glycemic excursions calculated using CGM data only in the Ins group (R2= 0.5242,P<0.001). CONCLUSIONS:Short-term glycemic control decreased serum TG and RemL-C levels, but not ApoB48 levels, and the postprandial metabolism of PG and CM might be regulated by the same mechanism except GLP-1 effect.
journal_name
J Atheroscler Thrombjournal_title
Journal of atherosclerosis and thrombosisauthors
Okajima F,Emoto N,Kato K,Sugihara Hdoi
10.5551/jat.32409subject
Has Abstractpub_date
2017-02-01 00:00:00pages
157-168issue
2eissn
1340-3478issn
1880-3873journal_volume
24pub_type
杂志文章,随机对照试验abstract:AIM:We have conducted medical surveys on two Japanese populations (Japanese Americans living in the US and native Japanese living in Japan) to investigate the impact of westernization of lifestyles on diseases in Japanese people. A 1998 survey revealed that the progression of carotid intima-media wall thickness (IMT) w...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.39578
更新日期:2017-10-01 00:00:00
abstract:AIM:Factor VII activating protease (FSAP) is a plasma serine protease involved in hemostasis and remodeling processes. Increased levels of circulating FSAP during pregnancy and in women using oral contraceptives (OCs) indicate that the hormonal status critically influences FSAP expression. In this respect, the aim of t...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.9589
更新日期:2012-01-01 00:00:00
abstract:AIM:Angiotensin-converting enzyme inhibitors (ACEIs) have been shown to block matrix metalloproteinase (MMP)-9 activity, which plays a role in atherogenesis. MMP-9 activity of macrophages is increased during foam cell formation. To investigate the contribution of ACEIs to foam cell formation, we studied the effects of ...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.1685
更新日期:2010-02-01 00:00:00
abstract:AIM:Resveratrol has been shown to mimic the beneficial effects of dietary restriction (DR). We previously reported that DR delays stroke onset and extends the lifespan in Stroke-Prone Spontaneously Hypertensive rats (SHRSP). Therefore, we examined whether resveratrol mimics DR and delays stroke onset in SHRSP. METHODS...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.27789
更新日期:2015-01-01 00:00:00
abstract:AIM:This study aimed to examine whether cardiorespiratory fitness (CRF) is associated with arterial stiffening, evaluated using the cardio-ankle vascular index (CAVI), independent of visceral fat (VF) in middle-aged and elderly Japanese men. We also examined whether the relationship between CRF and the CAVI is modified...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.25098
更新日期:2015-01-01 00:00:00
abstract::The aim of this study was to observe the efficacy of atorvastatin and the related factors of meeting the National Cholesterol Education Program (NCEP)-recommended low-density lipoprotein (LDL) cholesterol levels in patients with hypercholesterolemia. A total of 107 patients were treated with atorvastatin 10 mg/day for...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.10.19
更新日期:2003-01-01 00:00:00
abstract:AIM:The Japan Atherosclerosis Society Guidelines for the Diagnosis and Prevention of Atherosclerotic Cardiovascular Diseases 2012 (JAS Guidelines 2012) indicate that the management target for serum non-high-density lipoprotein cholesterol (non-HDLC) level is 30 mg/dL higher than that for low-density lipoprotein cholest...
journal_title:Journal of atherosclerosis and thrombosis
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doi:10.5551/jat.33068
更新日期:2016-01-01 00:00:00
abstract:AIM:Increasing evidence indicates that antimicrobial peptides, human neutrophil peptide-1, -2, and -3 (HNP1-3) and human antimicrobial peptide LL-37 are involved in the pathophysiology of atherosclerosis; however, little is known about their circulating protein levels in acute myocardial infarction (AMI). We therefore ...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.10108
更新日期:2012-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.28126
更新日期:2015-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.11.354
更新日期:2004-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.5579
更新日期:2011-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.32896
更新日期:2016-06-01 00:00:00
abstract:AIM:Speckle-tracking imaging has been introduced for the precise assessment of vessel mechanics. However, there are no data on the role of this imaging tool in assessing the changes in vasculature with statin therapy, which is known to enhance vascular elasticity. METHODS:This study was a prospective study including 4...
journal_title:Journal of atherosclerosis and thrombosis
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doi:10.5551/jat.42861
更新日期:2018-11-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.48223
更新日期:2019-12-01 00:00:00
abstract:AIM:Ezetimibe, an inhibitor of cholesterol intestinal absorption, is a lipid lowering agent. However, anti-atherogenic effects of ezetimibe have not been fully elucidated. Therefore, the objective in this study was to clarify the vascular protective effects of ezetimibe in patients with hypercholesterolemia. METHODS:E...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.9548
更新日期:2011-01-01 00:00:00
abstract::In atherosclerotic lesions, matrix metalloproteinases produced by foam cells (macrophages) are thought to increase plaque instability, promote plaque rupture, by degradating extracellular matrix. To investigate the relationship between the expression of these proteinases and the histologic appearance of atheromas, imm...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat1994.8.50
更新日期:2001-01-01 00:00:00
abstract:AIM:Cardio-ankle vascular index (CAVI) reflects arterial stiffness and has been established as a useful surrogate marker of atherosclerosis. Contrary to the abundant data indicating slower progression of atherosclerosis with statins, studies on fibrates remain scarce. The aim of this study was thus to clarify the effec...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,随机对照试验
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更新日期:2011-01-01 00:00:00
abstract:AIM:This study tested the hypothesis that tacrolimus therapy limited left ventricular (LV) infarct and remodeling by suppressing the inflammatory response, oxidative stress and regulating the mitogen-activated protein kinase (MAPK) and Akt signaling pathways in an acute myocardial infarction (AMI) mini-pig model by lig...
journal_title:Journal of atherosclerosis and thrombosis
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doi:10.5551/jat1994.4.102
更新日期:1998-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract:AIM:Ischemic stroke (IS) is a multifactorial disease caused by environmental risk factors and genetic susceptibility. However, few studies have assessed whether gene-gene interactions among cytochrome P450 (CYP) pathway genes influence the risk of IS. The aim of the present study was to investigate the association of 1...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.29025
更新日期:2015-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
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abstract::To determine the recent serum lipid levels in the general Japanese population and trends in their changes over the past 30 years, a nationwide survey of serum lipid levels was conducted in 39 institutes from various districts around Japan. The total number of subjects were 34,815, consisting of 20,279 men and 14,536 w...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat1994.2.122
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abstract:AIM:High density lipoprotein (HDL) and its apolipoproteins can promote cholesterol efflux from macrophage foam cells via the ATP-binding cassette transporter A1 (ABCA1), ABCG1, and scavenger receptor class B type I (SR-BI). Liver X receptors (LXRs) operate as cholesterol sensors which may protect from cholesterol overl...
journal_title:Journal of atherosclerosis and thrombosis
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更新日期:2010-05-01 00:00:00
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更新日期:2021-01-22 00:00:00
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abstract::Sitosterolemia is a rare, autosomal recessive inherited sterol storage disease associated with high tissue and serum plant sterol concentrations, caused by mutations in the adenosine triphosphate-bind-ing cassette (ABC) transporter ABCG5 or ABCG8 genes. Markedly increased serum concentration of plant sterols. such as ...
journal_title:Journal of atherosclerosis and thrombosis
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更新日期:2010-09-30 00:00:00