A Proposal for the Optimal Management Target for Serum Non-High-Density Lipoprotein Cholesterol Level in Low-Risk Japanese Workers.

abstract：AIM:Ischemic stroke (IS) is a multifactorial disease caused by environmental risk factors and genetic susceptibility. However, few studies have assessed whether gene-gene interactions among cytochrome P450 (CYP) pathway genes influence the risk of IS. The aim of the present study was to investigate the association of 1...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yi X,Liao D,Fu X,Zhang B,Wang C

更新日期：2015-01-01 00:00:00

abstract：AIM:All health insurers in Japan are mandated to provide Specific Health Checkups and Specific Health Guidance (SHG) focusing on metabolic syndrome (MetS) in middle-aged adults, beginning in 2008; intensive HG for individuals who have abdominal obesity and two or more additional MetS risk factors, and motivational HG f...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tsushita K,S Hosler A,Miura K,Ito Y,Fukuda T,Kitamura A,Tatara K

更新日期：2018-04-01 00:00:00

abstract：AIMS:Small arteries can be visualized in the ocular fundus, and findings of retinopathy based on Scheie classification are often applied to evaluate the impact of hypertension and atherosclerosis. However, the relationship between damage in the large and small arteries has not been investigated sufficiently, especially...

journal_title：Journal of atherosclerosis and thrombosis

authors： Sugiura T,Dohi Y,Takagi Y,Yokochi T,Yoshikane N,Suzuki K,Tomiishi T,Nagami T,Iwase M,Takase H,Seo Y,Ohte N

更新日期：2020-11-25 00:00:00

abstract：:A 77-year-old woman with type II diabetes mellitus was admitted to our hospital in August/ 1995 with severe hyperlipidemia. She had taken feedings through a nasogastric tube with 1000 ml (1000 kcal) of Ensureliquid daily since 1993 because of the muscle weakness after rhabdomyolysis. Her serum total cholesterol was 51...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tanaka S,Miki T,Hsieh ST,Kim JI,Yasumoto T,Taniguchi T,Ishikawa Y,Yokoyama M

更新日期：2003-01-01 00:00:00

abstract：AIM:Familial hypercholesterolemia (FH) is the most commonly encountered genetic condition that predisposes individuals to severe autosomal dominant lipid metabolism dysfunction. Although more than 75% of the European population has been scrutinized for FH-causing mutations, the genetic diagnosis proportion among Chines...

journal_title：Journal of atherosclerosis and thrombosis

authors： Wang H,Yang H,Liu Z,Cui K,Zhang Y,Zhang Y,Zhao K,Yin K,Li W,Zhou Z

更新日期：2020-12-01 00:00:00

abstract：:Even though it is only a little over a decade from the discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9) as a plasma protein that associates with both high and low cholesterol syndromes, a rich body of knowledge has developed, and drugs inhibiting this target have been approved in many markets. While ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Shapiro MD,Fazio S

更新日期：2017-05-01 00:00:00

abstract：AIM:Ultrasound protocols to measure carotid intima media thickness (CIMT) differ considerably with regard to the inclusion of the number of carotid segments and angles used. Detailed information on the completeness of CIMT information is often lacking in published reports, and at most, overall percentages are presented...

journal_title：Journal of atherosclerosis and thrombosis

authors： Dogan S,Duivenvoorden R,Grobbee DE,Kastelein JJ,Shear CL,Evans GW,Visseren FL,Bots ML,Radiance 1 and 2 Study Groups.

更新日期：2010-05-01 00:00:00

abstract：AIM:Since we previously reported that lower levels of HDL-C may be most useful for predicting coronary artery disease (CAD) as assessed by multi-detector row computed tomography (MDCT), we sought to confirm, among the levels of LDL-C, HDL-C, non-HDL-C (total cholesterol minus HDL-C) and the ratio of LDL-C to HDL-C (LDL...

journal_title：Journal of atherosclerosis and thrombosis

authors： Shiga Y,Miura S,Mitsutake R,Kawamura A,Uehara Y,Saku K

更新日期：2010-08-31 00:00:00

abstract：AIM:Studies have suggested that genetic and environmental factors do not account for all risks and mechanisms of intracranial atherosclerotic stenosis (ICAS). DNA methylation may play a role in the progression of ICAS. METHODS:DNA methylation profiles of peripheral blood leucocytes from 7 patients with early-onset ICA...

journal_title：Journal of atherosclerosis and thrombosis

authors： He XW,Zhao Y,Shi YH,Zhao R,Liu YS,Hu Y,Zhuang MT,Wu YL,Li GF,Yin JW,Cui GH,Liu JR

更新日期：2020-01-01 00:00:00

abstract：AIM:The ankle-brachial index(ABI) is an easy-to-use, non-invasive and reliable diagnostic tool for assessing peripheral arterial occlusive disease(PAOD). The CHADS2(congestive heart failure, hypertension, age ≧75 years, diabetes, prior stroke) score is a simple and popular clinical parameter that is used to assess the ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hsu PC,Lin TH,Lee WH,Chu CY,Chiu CA,Lee HH,Su HM,Voon WC,Lai WT,Sheu SH

更新日期：2014-01-01 00:00:00

abstract：AIM:Cardio-ankle vascular index (CAVI) reflects arterial stiffness and has been established as a useful surrogate marker of atherosclerosis. Contrary to the abundant data indicating slower progression of atherosclerosis with statins, studies on fibrates remain scarce. The aim of this study was thus to clarify the effec...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yamaguchi T,Shirai K,Nagayama D,Nakamura S,Oka R,Tanaka S,Watanabe Y,Imamura H,Sato Y,Kawana H,Ohira M,Saiki A,Shimizu N,Tatsuno I

更新日期：2019-07-01 00:00:00

abstract：AIMS:Statins not only reduce low-density lipoprotein (LDL) cholesterol, but also prevent the progression of kidney dysfunction. Ezetimibe, a cholesterol-absorption inhibitor, also lowers LDL cholesterol levels when added to statins; however, the effect of add-on ezetimibe on kidney function has had conflicting results....

journal_title：Journal of atherosclerosis and thrombosis

authors： Kinouchi K,Ichihara A,Bokuda K,Morimoto S,Itoh H

更新日期：2013-01-01 00:00:00

abstract：AIM:Recent studies have suggested that hyperinsulinemia is associated with high cardiovascular risk. The purpose of this study was to assess the relationship between the serum insulin level and coronary artery calcification (CAC). METHODS:We performed a cross-sectional study of 582 consecutive and nondiabetic particip...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tanaka M,Fukui M,Tomiyasu K,Akabame S,Nakano K,Hasegawa G,Oda Y,Nakamura N

更新日期：2010-10-27 00:00:00

abstract：:Vascular calcification is a common feature of advanced atherosclerosis resulting in reduced elasticity of elastic arteries. However, the relationship between elastic fibers and vascular calcification at the molecular and cellular levels remains unknown. We investigated the expression of major elastic fiber components ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Sugitani H,Wachi H,Mecham RP,Seyama Y

更新日期：2002-01-01 00:00:00

abstract：AIM:To evaluate whether plaque scoring measurements are able to track changes in atherosclerotic plaque burden over time and to study whether this is affected by lipid-lowering therapy. METHODS:Data used were from METEOR (Measuring Effects on Intima-Media Thickness: an Evaluation Of Rosuvastatin), a randomized control...

journal_title：Journal of atherosclerosis and thrombosis

authors： Peters SA,Dogan S,Meijer R,Palmer MK,Grobbee DE,Crouse JR 3rd,O'Leary DH,Evans GW,Raichlen JS,Bots ML

更新日期：2011-01-01 00:00:00

abstract：AIM:To examine the impact of C-reactive protein on the risks of stroke and its subtypes, particularly among Asian populations in which median C-reactive protein levels are typically lower than in Western populations. METHODS:A prospective, nested case-control study was conducted to examine the associations between hig...

journal_title：Journal of atherosclerosis and thrombosis

authors： Iso H,Noda H,Ikeda A,Yamagishi K,Inoue M,Iwasaki M,Tsugane S

更新日期：2012-01-01 00:00:00

abstract：AIM:The Vietnamese develop type 2 diabetes (T2D) and metabolic syndrome (MS) at a lower BMI than other ethnicities. Thus, biomarkers that identify subjects at an increased risk of T2D independently of obesity are being sought. Recent studies show that circulating NO metabolites (NOx) are increased in T2D. We investigat...

journal_title：Journal of atherosclerosis and thrombosis

authors： Binh PN,Abe Y,Tien PG,Son le NT,Hanh TT,Diep do TN,Qui le TK,Kawano M,Maruyama C

更新日期：2011-01-01 00:00:00

abstract：AIM:To examine the association between renal vasculature changes and generalized atherosclerosis using autopsy cases. METHODS:We histologically examined 107 autopsy patients(mean age, 68.4 years; 64% men; 81% non-CVD) to investigate the association between renal vasculature changes and generalized atherosclerosis. We ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Iwakiri T,Sato Y,Matsuura Y,Hatakeyama K,Marutsuka K,Yamashita A,Fujimoto S,Kitamura K,Asada Y

更新日期：2014-01-01 00:00:00

abstract：AIM:Carotid intima-media thickness (CIMT) measurements are used as a disease outcome in randomized controlled trials that assess the effects of lipid-modifying treatment. It is unclear whether common CIMT or mean maximum CIMT should be used as the primary outcome. We directly compared both measurements using aspects th...

journal_title：Journal of atherosclerosis and thrombosis

authors： Dogan S,Kastelein JJ,Grobbee DE,Bots ML

更新日期：2011-01-01 00:00:00

abstract：:The signaling and functions of the Endothelial Differentiation Gene (EDG) family of G protein-coupled receptors have been extensively elucidated. All the members of EDG family were shown to be receptors for lysosphingolipids or lysophospholipids. EDG-1, the prototype of EDG family receptors, is a high affinity recepto...

journal_title：Journal of atherosclerosis and thrombosis

authors： Ozaki H,Hla T,Lee MJ

更新日期：2003-01-01 00:00:00

abstract：AIMS:Fasting and postprandial hypertriglyceridemia (PHTG) are caused by the accumulation of triglyceride (TG)-rich lipoproteins and their remnants, which have atherogenic effects. Fibrates can improve fasting and PHTG; however, reduction of remnants is clinically needed to improve health outcomes. In the current study,...

journal_title：Journal of atherosclerosis and thrombosis

authors： Sairyo M,Kobayashi T,Masuda D,Kanno K,Zhu Y,Okada T,Koseki M,Ohama T,Nishida M,Sakata Y,Yamashita S

更新日期：2018-02-01 00:00:00

abstract：AIM:Withholding effective treatment is clinically prevalent. The CEntralized Pan-Asian survey on tHE Under-treatment of hypercholeSterolemia (CEPHEUS-PA) indicated suboptimal low-density lipoprotein cholesterol (LDL-C) goal attainment in Taiwan, which may be attributable to clinical inertia. We herein analyzed the Taiw...

journal_title：Journal of atherosclerosis and thrombosis

authors： Wang KL,Wu CH,Wang KF,Chang CC,Chen LC,Lu TM,Lin SJ,Chiang CE

更新日期：2014-01-01 00:00:00

abstract：AIM:Atrial fibrillation (AF) is characterized by the development of thromboembolic events and is more prevalent among end-stage renal disease patients than in the general population. Vascular access thrombosis (VAT) is a major morbidity in chronic hemodialysis (HD) patients; however, the association between AF and VAT ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Chou CY,Chen JY,Liu JH,Liu YL,Lin HH,Yang YF,Wang SM,Kuo HL,Huang CC

更新日期：2011-01-01 00:00:00

abstract：AIM:Nephrotic syndrome (NS) is associated with an increased rate of cardiovascular events. The YKL-40 level is associated with atherosclerosis, endothelial dysfunction and proteinuria in renal and non-renal populations. The aim of this study was to investigate the relationships between the YKL-40 level and both vascula...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kocyigit I,Gungor O,Dogan E,Karadavut S,Karakukcu C,Eroglu E,Orscelik O,Unal A,Dogan A,Sipahioglu MH,Tokgoz B,Oymak O

更新日期：2015-01-01 00:00:00

abstract：AIM:A simple, non-invasive medical device, using bioelectrical impedance analysis (BIA) for the evaluation of visceral fat level (VFL) was developed recently. The aim of this study was to investigate the utility of VFL by BIA in the screening of metabolic syndrome (MetS). METHODS:VFL was measured by the BIA device in ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Unno M,Furusyo N,Mukae H,Koga T,Eiraku K,Hayashi J

更新日期：2012-01-01 00:00:00

abstract：AIM:To demonstrate the clinical benefit of inhibiting intestinal cholesterol absorption, we evaluated the effects of ezetimibe on surrogate markers of cholesterol absorption and synthesis, lipid and glucose metabolism, and markers of obesity and inflammation. METHODS:A total of 120 patients with dyslipidemia (46 men; ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hiramitsu S,Ishiguro Y,Matsuyama H,Yamada K,Kato K,Noba M,Uemura A,Yoshida S,Matsubara Y,Kani A,Hasegawa K,Hishida H,Ozaki Y

更新日期：2010-02-01 00:00:00

abstract：AIM:Inter-arm blood pressure difference (IAD) is known to be associated with a composite of cardiovascular disease (CVD) and with CVD risk factors. However, only limited information is available regarding the contribution of diabetes mellitus to IAD and the association of IAD with individual CVDs, such as coronary arte...

journal_title：Journal of atherosclerosis and thrombosis

authors： Miyashima M,Shoji T,Kakutani Y,Yamazaki Y,Ochi A,Morioka T,Shinohara-Mitsuki K,Fukumoto S,Shioi A,Inaba M,Emoto M

更新日期：2020-08-01 00:00:00

abstract：:Due to the pandemics of obesity and diabetes mellitus, especially in the Western countries, atherosclerotic cardiovascular disease (ASCVD) has become a major health burden and is expected to increase in the future. Modifying lipid targets, especially low-density lipoprotein cholesterol (LDL-C) level, has become the fi...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kataoka Y,Andrews J,Puri R,Psaltis P,Nicholls SJ

更新日期：2017-04-03 00:00:00

abstract：AIM:To investigatethe association of plasma epoxyeicosatrienoic acids (EETs) with early neurologic deterioration (END), and whether EETs are mediated by EPHX2 variants in patients with minor ischemic stroke (MIS). METHOD:This was a prospective, multi-center observational study in patients with acute MIS in the Chinese...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yi X,Lin J,Li J,Zhou Q,Han Z

更新日期：2017-12-01 00:00:00

abstract：AIM:Although current guidelines recommend surgical revascularization as the first-line therapy for chronic total occlusion of the abdominal aorta (Leriche syndrome), endovascular therapy (EVT) has been increasingly utilized because of the development of new technologies and techniques. EVT has demonstrated durable midt...

journal_title：Journal of atherosclerosis and thrombosis

authors： Nanto K,Iida O,Fujihara M,Yokoi Y,Tomoi Y,Soga Y,Fujita M,Masuda M,Okamoto S,Ishihara T,Kanda T,Tsujimura T,Matsuda Y,Okuno S,Mano T

更新日期：2019-11-01 00:00:00