当前位置： SCI文献检索 > Journal of Atherosclerosis and Thrombosis期刊下所有文献 > Mean common or mean maximum carotid intima-media thickness as primary outcome in lipid-modifying intervention studies.

Mean common or mean maximum carotid intima-media thickness as primary outcome in lipid-modifying intervention studies.

Abstract：

AIM:Carotid intima-media thickness (CIMT) measurements are used as a disease outcome in randomized controlled trials that assess the effects of lipid-modifying treatment. It is unclear whether common CIMT or mean maximum CIMT should be used as the primary outcome. We directly compared both measurements using aspects that are of great importance in deciding which is most favorable for use in clinical trials. METHODS:A literature search was performed (PUBMED, up to March 31, 2008). Fifteen trials with lipid-modifying treatment were identified that had information on both outcome measures. Common CIMT and mean maximum CIMT were compared on reproducibility, strength of relation with LDL and HDL cholesterol and congruency of their results (harm/neutral/beneficial) with data from event trials. RESULTS:Findings showed that the reported reproducibility was high for both measurements, although a direct comparison was not possible. The relationship between the achieved LDL-C and HDL-C levels with CIMT progression was modest and showed no difference in magnitude between CIMT measurements. CIMT progression rates differed across carotid segments with the highest progression rates observed in the bifurcation segment. Treatment effects differed across carotid segments without a clear preference pattern. Trials using mean maximum CIMT progression more often (12 out of 15 studies) paralleled the findings of event trials in contrast to the mean common CIMT (11 out of 15 studies), a difference not reaching statistical significance. CONCLUSIONS:Based on the literature, with equal results for reproducibility (assumed), lipid relationship and congruency with event findings, but with treatment effects that differ across carotid segments that can not be predicted, the mean maximum CIMT as the primary outcome may be preferred in trials on the impact of lipid-modifying interventions. One advantage is that information on mean common CIMT can generally be obtained easily in protocols assessing mean maximum CIMT, but not the other way around.

journal_name

J Atheroscler Thromb

journal_title

Journal of atherosclerosis and thrombosis

authors

Dogan S,Kastelein JJ,Grobbee DE,Bots ML

doi

10.5551/jat.8623

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

946-57

issue

eissn

1340-3478

issn

1880-3873

pii

JST.JSTAGE/jat/8623

journal_volume

pub_type

杂志文章

在线工具

Mean common or mean maximum carotid intima-media thickness as primary outcome in lipid-modifying intervention studies.