Current therapy for patients with sitosterolemia--effect of ezetimibe on plant sterol metabolism.

abstract：AIM:It has been reported that beta-blockers (BB) reduce cardiovascular events in patients with atherosclerotic disease. However, little is known about the efficacy of these drugs in patients with critical limb ischemia (CLI). We investigated whether beta-blocker therapy affects the clinical outcomes of CLI patients. M...

journal_title：Journal of atherosclerosis and thrombosis

authors： Soga Y,Iida O,Takahara M,Hirano K,Suzuki K,Kawasaki D

更新日期：2015-01-01 00:00:00

abstract：AIM:We investigated the effects of a calorie-restricted low-carbohydrate diet on glucose and lipid metabolism, and body fat distribution, especially on the secretion of leptin and lipoprotein lipase from adipose tissue in Otsuka Long Evans Tokushima Fatty (OLETF) rats. METHODS:Forty-three week-old male OLETF rats were...

journal_title：Journal of atherosclerosis and thrombosis

authors： Koide N,Oyama T,Miyashita Y,Shirai K

更新日期：2007-10-01 00:00:00

abstract：:Calcium deposits account for most of the dry weight of atherosclerotic lesions. Previously considered uncommon, vascular calcification is now known to be present in 80% of significant lesions and in at least 90% of patients with coronary artery disease. Previously considered a passive process, it is increasingly recog...

journal_title：Journal of atherosclerosis and thrombosis

authors： Parhami F,Boström K,Watson K,Demer LL

更新日期：1996-01-01 00:00:00

abstract：AIM:The levels of lipids, especially triglycerides (TG), and obesity are associated with diabetes mellitus (DM). Although typically measured in fasting individuals, non-fasting lipid measurements play an important role in predicting future DM. This study compared the predictive efficacy of lipid variables according to ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Fujihara K,Sugawara A,Heianza Y,Sairenchi T,Irie F,Iso H,Doi M,Shimano H,Watanabe H,Sone H,Ota H

更新日期：2014-01-01 00:00:00

abstract：:We now have discovered and characterized a novel multi-domain protein and classified it as a member of the LDL receptor gene family. The approximately 250 kDa membrane protein, termed LR11, highly conserved in man, rabbit and chicken, contains a cluster of 11 LDL receptor ligand binding repeats, a group of 5 LDL recep...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yamazaki H,Bujo H,Saito Y

更新日期：1997-01-01 00:00:00

abstract：AIM:Existing evidence suggests that endothelial lipase (EL) plays an important role in high-densitylipoprotein (HDL) metabolism. Because rabbits are a useful animal model for the study of human lipid metabolism and atherosclerosis, we characterized rabbit EL (rEL) expression and investigated its relationship with plasm...

journal_title：Journal of atherosclerosis and thrombosis

authors： Zhang J,Yu Y,Nakamura K,Koike T,Waqar AB,Zhang X,Liu E,Nishijima K,Kitajima S,Shiomi M,Qi Z,Yu J,Graham MJ,Crooke RM,Ishida T,Hirata K,Hurt-Camejo E,Chen YE,Fan J

更新日期：2012-01-01 00:00:00

abstract：AIM:Adipose tissue inflammation induced by macrophage infiltration through the MCP-1/CCR2 pathway is considered to play a pivotal role in the development of visceral obesity and insulin resistance. In the present study, therefore, we examined whether pharmacological inhibition of CCR2 is effective against the developme...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tamura Y,Sugimoto M,Murayama T,Minami M,Nishikaze Y,Ariyasu H,Akamizu T,Kita T,Yokode M,Arai H

更新日期：2010-03-31 00:00:00

abstract：AIM:We investigated whether any seasonal variation is observed in the incidence, severity and prognosis of critical limb ischemia (CLI) requiring endovascular therapy. METHODS:We analyzed a multicenter database of 1,568 consecutive CLI cases undergoing primary endovascular therapy for infrainguinal lesions between Jul...

journal_title：Journal of atherosclerosis and thrombosis

authors： Takahara M,Iida O,Soga Y,Hirano K,Yamaoka T,Kawasaki D,Suzuki K,Suematsu N,Shintani Y,Miyashita Y,Kaneto H,Shimomura I

更新日期：2013-01-01 00:00:00

abstract：AIM:A new antibody reacted with an epitope in Lp(a) that has undergone oxidation treatment, but is not present in native Lp(a), was developed. Thus, we determined serum oxidized Lp(a) concentration in healthy volunteers, and coronary artery disease (CAD), diabetes mellitus (DM), and hypertensive patients. METHODS:We m...

journal_title：Journal of atherosclerosis and thrombosis

authors： Morishita R,Ishii J,Kusumi Y,Yamada S,Komai N,Ohishi M,Nomura M,Hishida H,Niihashi M,Mitsumata M

更新日期：2009-08-01 00:00:00

abstract：:Recent findings suggest that the oxidative modification of low-density lipoproteins (LDL) and an increase in triglyceride-rich lipoprotein particles including chylomicron remnants contribute to the progression of atherosclerosis, as does the inflammatory response. We therefore examined whether and how these lipoprotei...

journal_title：Journal of atherosclerosis and thrombosis

authors： Okumura T,Fujioka Y,Morimoto S,Masai M,Sakoda T,Tsujino T,Kashiwamura S,Okamura H,Ohyanagi M

更新日期：2006-02-01 00:00:00

abstract：AIM:It remains uncertain whether chronic exposure to particulate air pollution is associated with increased mortality in Japan because Japan has a different distribution pattern of cardiovascular disease and its risk factors compared to Western countries. We investigated the association between long-term exposure to pa...

journal_title：Journal of atherosclerosis and thrombosis

authors： Ueda K,Nagasawa SY,Nitta H,Miura K,Ueshima H,NIPPON DATA80 Research Group.

更新日期：2012-01-01 00:00:00

abstract：:Zetia (ezetimibe) is a selective cholesterol absorption inhibitor, which potently inhibits the absorption of biliary and dietary cholesterol from the small intestine without affecting the absorption of fat-soluble vitamins, triglycerides or bile acids. Ezetimibe reduces the small intestinal enterocyte uptake and absor...

journal_title：Journal of atherosclerosis and thrombosis

authors： Davis HR,Veltri EP

更新日期：2007-06-01 00:00:00

abstract：AIM:Heterozygous patients with familial hypercholesterolemia (FH) are known to be associated with a high risk of coronary artery disease (CAD), which is a major determinant of their clinical outcome. The prognosis of heterozygous FH patients substantially varies, being dependent on the level of their CAD risk, and thei...

journal_title：Journal of atherosclerosis and thrombosis

authors： Sugisawa T,Okamura T,Makino H,Watanabe M,Kishimoto I,Miyamoto Y,Iwamoto N,Yamamoto A,Yokoyama S,Harada-Shiba M

更新日期：2012-01-01 00:00:00

abstract：AIM:The prospective, randomized, multicenter Myocardial Ischemia Treated with Percutaneous Coronary Intervention and Plaque Regression by Lipid Lowering & Blood Pressure Controlling assessed by Intravascular Ultrasonography (MILLION) study demonstrated that combined treatment with atorvastatin and amlodipine enhanced c...

journal_title：Journal of atherosclerosis and thrombosis

authors： Sakata K,Gamou T,Tada H,Hayashi K,Ino H,Yamagishi M,Masa-aki Kawashiri.,behalf of the MILLION Study Group.

更新日期：2019-05-01 00:00:00

abstract：:Dysregulation of adipose tissue-derived bioactive molecules, termed adipokines, is recognized as common ground for insulin resistance and metabolic syndrome associated with obesity. However, adipokine dysregulation is paradoxically associated with lipodystrophy and lipoatrophy with aging. In familial partial lipodystr...

journal_title：Journal of atherosclerosis and thrombosis

authors： Arai Y,Takayama M,Abe Y,Hirose N

更新日期：2011-01-01 00:00:00

abstract：:To determine the recent serum lipid levels in the general Japanese population and trends in their changes over the past 30 years, a nationwide survey of serum lipid levels was conducted in 39 institutes from various districts around Japan. The total number of subjects were 34,815, consisting of 20,279 men and 14,536 w...

journal_title：Journal of atherosclerosis and thrombosis

authors：

更新日期：1996-01-01 00:00:00

abstract：AIM:Inter-arm blood pressure difference (IAD) is known to be associated with a composite of cardiovascular disease (CVD) and with CVD risk factors. However, only limited information is available regarding the contribution of diabetes mellitus to IAD and the association of IAD with individual CVDs, such as coronary arte...

journal_title：Journal of atherosclerosis and thrombosis

authors： Miyashima M,Shoji T,Kakutani Y,Yamazaki Y,Ochi A,Morioka T,Shinohara-Mitsuki K,Fukumoto S,Shioi A,Inaba M,Emoto M

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Although insulin resistance (IR) is present in non-diabetic subjects, it is unknown whether IR affects statin treatment. We assessed the relationship between IR and the changes of lipid profile in patients with hyperlipidemia treated by atorvastatin. METHODS:Forty-four non-diabetic patients were included. H...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yoshitomi Y,Ishii T,Kaneki M,Tsujibayashi T,Sakurai S,Nagakura C,Miyauchi A

更新日期：2005-01-01 00:00:00

abstract：:Our purpose was to determine whether lipid peroxides are elevated in the plasma of patients with non-insulin dependent diabetes with multiple lacunar infarcts as detected by magnetic resonance imaging (MRI), and to confirm whether peroxide levels correlate with glycemic controls and blood lipid levels. The level of li...

journal_title：Journal of atherosclerosis and thrombosis

authors： Fujiwara Y,Nishihara H,Nakakoshi T,Hasegawa T,Tagami S,Kawakami Y

更新日期：1997-01-01 00:00:00

abstract：AIM:To examine the association between renal vasculature changes and generalized atherosclerosis using autopsy cases. METHODS:We histologically examined 107 autopsy patients(mean age, 68.4 years; 64% men; 81% non-CVD) to investigate the association between renal vasculature changes and generalized atherosclerosis. We ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Iwakiri T,Sato Y,Matsuura Y,Hatakeyama K,Marutsuka K,Yamashita A,Fujimoto S,Kitamura K,Asada Y

更新日期：2014-01-01 00:00:00

abstract：AIMS:The clinical implications of stiffness of the carotid artery (CA) have not been fully clarified in the prediction of coronary artery disease (CAD), although intima-media thickness (IMT) has been established as a surrogate marker. We examined the associations of stiffness parameter beta (ST) and IMT with concurrent...

journal_title：Journal of atherosclerosis and thrombosis

authors： Lee E,Emoto M,Teramura M,Tsuchikura S,Ueno H,Shinohara K,Morioka T,Mori K,Koyama H,Shoji T,Okuno Y,Inaba M,Nishizawa Y

更新日期：2009-03-01 00:00:00

abstract：AIM:We have conducted medical surveys on two Japanese populations (Japanese Americans living in the US and native Japanese living in Japan) to investigate the impact of westernization of lifestyles on diseases in Japanese people. A 1998 survey revealed that the progression of carotid intima-media wall thickness (IMT) w...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kubota M,Yoneda M,Watanabe H,Egusa G

更新日期：2017-10-01 00:00:00

abstract：AIM:To study atherosclerosis risk in diabetes, we investigated ATP-binding cassette transporter A1 (ABCA1) expression and high-density lipoprotein (HDL) biogenesis in the liver and hepatocytes under hyperglycemic conditions. METHODS AND RESULTS:In streptozotocin-induced diabetic mice, plasma HDL decreased while ABCA1 ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tsujita M,Hossain MA,Lu R,Tsuboi T,Okumura-Noji K,Yokoyama S

更新日期：2017-11-01 00:00:00

abstract：AIM:To investigatethe association of plasma epoxyeicosatrienoic acids (EETs) with early neurologic deterioration (END), and whether EETs are mediated by EPHX2 variants in patients with minor ischemic stroke (MIS). METHOD:This was a prospective, multi-center observational study in patients with acute MIS in the Chinese...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yi X,Lin J,Li J,Zhou Q,Han Z

更新日期：2017-12-01 00:00:00

abstract：:To study exogenous sterol metabolism during the suppression or stimulation of cholesterol biosynthesis induced by treatments for hyperlipidemia, we determined plasma plant sterol concentrations before and after administration of an HMG-CoA reductase inhibitor, pravastatin, and compared these with changes in these plas...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hidaka H,Kojima H,Kawabata T,Nakamura T,Konaka K,Kashiwagi A,Kikkawa R,Shigeta Y

更新日期：1995-01-01 00:00:00

abstract：AIM:Cardio-ankle vascular index (CAVI) reflects arterial stiffness and has been established as a useful surrogate marker of atherosclerosis. Contrary to the abundant data indicating slower progression of atherosclerosis with statins, studies on fibrates remain scarce. The aim of this study was thus to clarify the effec...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yamaguchi T,Shirai K,Nagayama D,Nakamura S,Oka R,Tanaka S,Watanabe Y,Imamura H,Sato Y,Kawana H,Ohira M,Saiki A,Shimizu N,Tatsuno I

更新日期：2019-07-01 00:00:00

abstract：AIMS:Fasting and postprandial hypertriglyceridemia (PHTG) are caused by the accumulation of triglyceride (TG)-rich lipoproteins and their remnants, which have atherogenic effects. Fibrates can improve fasting and PHTG; however, reduction of remnants is clinically needed to improve health outcomes. In the current study,...

journal_title：Journal of atherosclerosis and thrombosis

authors： Sairyo M,Kobayashi T,Masuda D,Kanno K,Zhu Y,Okada T,Koseki M,Ohama T,Nishida M,Sakata Y,Yamashita S

更新日期：2018-02-01 00:00:00

abstract：:Bilirubin is a fundamental metabolic end product of heme degradation. Despite acting as a cytotoxic metabolite at high concentrations, bilirubin at physiological concentrations has antioxidant effects, such as scavenging reactive oxygen species, leading to a decrease in oxidative stress. Endothelial dysfunction is an ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Maruhashi T,Kihara Y,Higashi Y

更新日期：2019-08-01 00:00:00

abstract：AIM:In animals, dietary energy restriction is reported to increase longevity, whereas in humans, all cohort studies from Western countries have not shown an association between the low energy intake and longevity. We examined the association between total energy intake and longevity in Japan where dietary pattern is di...

journal_title：Journal of atherosclerosis and thrombosis

authors： Nagai M,Ohkubo T,Miura K,Fujiyoshi A,Okuda N,Hayakawa T,Yoshita K,Arai Y,Nakagawa H,Nakamura K,Miyagawa N,Takashima N,Kadota A,Murakami Y,Nakamura Y,Abbott RD,Okamura T,Okayama A,Ueshima H,NIPPON DATA80 Research Gro

更新日期：2016-01-01 00:00:00

abstract：AIM:Glucagon-like peptide-1 can reduce both postprandial plasma glucose (PG) and chylomicron (CM) levels in patients with type 2 diabetes. However, there have been no reports regarding the relationship between the postprandial metabolism of PG and CM. METHODS:Patients with type 2 diabetes who were admitted for glycemi...

journal_title：Journal of atherosclerosis and thrombosis

authors： Okajima F,Emoto N,Kato K,Sugihara H

更新日期：2017-02-01 00:00:00