Chylomicron remnants stimulate release of interleukin-1beta by THP-1 cells.

abstract：:We studied the association of six common polymorphisms of four genes related to lipid metabolism with serum lipid levels. We selected single-nucleotide polymorphisms (SNPs) in the genes for cholesteryl ester transfer protein (CETP), lipoprotein lipase (LPL), hepatic lipase (LIPC), and apolipoprotein CIII (APOC3), and ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Arai H,Yamamoto A,Matsuzawa Y,Saito Y,Yamada N,Oikawa S,Mabuchi H,Teramoto T,Sasaki J,Nakaya N,Itakura H,Ishikawa Y,Ouchi Y,Horibe H,Egashira T,Hattori H,Shirahashi N,Kita T

更新日期：2005-01-01 00:00:00

abstract：AIM:The clinical relevance of the suggested pleiotropic effects of hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) is controversial. Aggressive statins effectively reduce lipid levels, but whether their other effects are more powerful than those of regular statins is unknown. METHODS:We enrolled 32 pat...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hoshiga M,Arishiro K,Nakakoji T,Miyazaki N,Negoro N,Okabe T,Kohbayashi E,Ishihara T,Hanafusa T

更新日期：2010-07-30 00:00:00

abstract：AIM:Since we previously reported that lower levels of HDL-C may be most useful for predicting coronary artery disease (CAD) as assessed by multi-detector row computed tomography (MDCT), we sought to confirm, among the levels of LDL-C, HDL-C, non-HDL-C (total cholesterol minus HDL-C) and the ratio of LDL-C to HDL-C (LDL...

journal_title：Journal of atherosclerosis and thrombosis

authors： Shiga Y,Miura S,Mitsutake R,Kawamura A,Uehara Y,Saku K

更新日期：2010-08-31 00:00:00

abstract：AIM:Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders associated with metabolic syndrome, and its prevalence has been on the rise. The pathogenesis of NAFLD has not yet been sufficiently elucidated due to the multifactorial nature of the disease, although the activation of macr...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yoshii D,Nakagawa T,Komohara Y,Kawaguchi H,Yamada S,Tanimoto A

更新日期：2020-10-02 00:00:00

abstract：AIM:Children exposed to parental smoking are at increased long-term risk of subclinical atherosclerosis in adulthood. However, it has not been quantified if exposure to parental smoking in childhood is associated with adult systemic inflammation. This study aimed to determine if childhood exposure to parental smoking w...

journal_title：Journal of atherosclerosis and thrombosis

authors： Wang D,Juonala M,Viikari JSA,Wu F,Hutri-Kähönen N,Raitakari OT,Magnussen CG

更新日期：2017-12-01 00:00:00

abstract：:To determine the recent serum lipid levels and other serum variables in the general Japanese population and trends in their changes over the past 40 years, a nationwide survey of serum lipid levels was conducted in 36 institutes from various districts around Japan in 2000. The total number of subjects was 12,839, aged...

journal_title：Journal of atherosclerosis and thrombosis

authors： Arai H,Yamamoto A,Matsuzawa Y,Saito Y,Yamada N,Oikawa S,Mabuchi H,Teramoto T,Sasaki J,Nakaya N,Itakura H,Ishikawa Y,Ouchi Y,Horibe H,Kita T

更新日期：2005-01-01 00:00:00

abstract：AIM:It has been reported that beta-blockers (BB) reduce cardiovascular events in patients with atherosclerotic disease. However, little is known about the efficacy of these drugs in patients with critical limb ischemia (CLI). We investigated whether beta-blocker therapy affects the clinical outcomes of CLI patients. M...

journal_title：Journal of atherosclerosis and thrombosis

authors： Soga Y,Iida O,Takahara M,Hirano K,Suzuki K,Kawasaki D

更新日期：2015-01-01 00:00:00

abstract：:To study exogenous sterol metabolism during the suppression or stimulation of cholesterol biosynthesis induced by treatments for hyperlipidemia, we determined plasma plant sterol concentrations before and after administration of an HMG-CoA reductase inhibitor, pravastatin, and compared these with changes in these plas...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hidaka H,Kojima H,Kawabata T,Nakamura T,Konaka K,Kashiwagi A,Kikkawa R,Shigeta Y

更新日期：1995-01-01 00:00:00

abstract：:Cardiovascular disease constitutes the major cause of mortality in patients with chronic kidney disease. Arterial stiffness is an important contributor to the occurrence and progression of cardiovascular disease. Various risk factors, including altered hormone levels, have been suggested to be associated with arterial...

journal_title：Journal of atherosclerosis and thrombosis

authors： Gungor O,Kircelli F,Voroneanu L,Covic A,Ok E

更新日期：2013-01-01 00:00:00

abstract：AIM:In addition to the risk of progression to end-stage renal disease (ESRD), chronic kidney disease (CKD) is also known to be associated with an elevated risk of cardiovascular disease (CVD). Statins may improve renal function in CKD patients. METHODS:The database of the LIVALO Effectiveness and Safety (LIVES) Study,...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kimura K,Shimano H,Yokote K,Urashima M,Teramoto T

更新日期：2010-06-30 00:00:00

abstract：AIM:The association between urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), an oxidative stress marker, and the incidence of cardiovascular disease (CVD) has not been confirmed because no previous studies evaluated 24-hour 8-OHdG excretion levels in the general population. We aimed to confirm the association between 24-h...

journal_title：Journal of atherosclerosis and thrombosis

authors： Nagao M,Kobashi G,Umesawa M,Cui R,Yamagishi K,Imano H,Okada T,Kiyama M,Kitamura A,Sairenchi T,Haruyama Y,Ohira T,Iso H,CIRCS Investigators.

更新日期：2020-10-01 00:00:00

abstract：AIM:High density lipoprotein (HDL) and its apolipoproteins can promote cholesterol efflux from macrophage foam cells via the ATP-binding cassette transporter A1 (ABCA1), ABCG1, and scavenger receptor class B type I (SR-BI). Liver X receptors (LXRs) operate as cholesterol sensors which may protect from cholesterol overl...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hu YW,Wang Q,Ma X,Li XX,Liu XH,Xiao J,Liao DF,Xiang J,Tang CK

更新日期：2010-05-01 00:00:00

abstract：AIM:Coronary artery stenosis (CAS) ≥ 50% frequently coexists in patients with acute ischemic cerebrovascular disease (AICVD), which portends unfavorable outcomes. We sought to examine whether patients with AICVD with CAS had more severe and more diffused cervicocephalic atherosclerosis (CA). METHODS:Patients with AICV...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kong Q,Ma X,Wang C,Feng W,Ovbiagele B,Zhang Y,Du X

更新日期：2019-09-01 00:00:00

abstract：AIM:A novel device has been developed for measuring the cardio-ankle vascular index (CAVI) as an indicator of arterial stiffness. In this study, we evaluated the effect of pitavastatin on CAVI in type 2 diabetic patients. METHODS:Forty-five type 2 diabetes mellitus patients with low-density lipoprotein cholesterolemia...

journal_title：Journal of atherosclerosis and thrombosis

authors： Miyashita Y,Endo K,Saiki A,Ban N,Yamaguchi T,Kawana H,Nagayama D,Ohira M,Oyama T,Shirai K

更新日期：2009-10-01 00:00:00

abstract：:Hypertriglyceridemia is often associated with small dense low density lipoprotein (LDL), elevated remnants, and decreased high density lipoprotein (HDL)-cholesterol (C), which comprise the dyslipidemic triad. The objective of this study was to investigate the effect of fenofibrate on the lipoprotein subfraction profil...

journal_title：Journal of atherosclerosis and thrombosis

authors： Ikewaki K,Tohyama J,Nakata Y,Wakikawa T,Kido T,Mochizuki S

更新日期：2004-01-01 00:00:00

abstract：AIM:The risk index for atherosclerotic cardiovascular diseases in the Japanese metabolic syndrome-focused health checkup program was changed from total cholesterol (TC) to low-density lipoprotein cholesterol (LDL-C). We discuss the validity of this change with respect to standardization. METHODS:The beta-quantificatio...

journal_title：Journal of atherosclerosis and thrombosis

authors： Nakamura M,Koyama I,Iso H,Sato S,Okazaki M,Kayamori Y,Kiyama M,Kitamura A,Shimamoto T,Ishikawa Y

更新日期：2010-12-26 00:00:00

abstract：BACKGROUND:Although insulin resistance (IR) is present in non-diabetic subjects, it is unknown whether IR affects statin treatment. We assessed the relationship between IR and the changes of lipid profile in patients with hyperlipidemia treated by atorvastatin. METHODS:Forty-four non-diabetic patients were included. H...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yoshitomi Y,Ishii T,Kaneki M,Tsujibayashi T,Sakurai S,Nagakura C,Miyauchi A

更新日期：2005-01-01 00:00:00

abstract：AIM:Associations between long-term exposure to particulate matter (PM) and increased cardiovascular mortality have been reported, but few studies have investigated the associated incidence of cardiovascular disease, and none involved men. METHODS:We used data on 78,057 participants (37,121 men, 40,936 women) to examin...

journal_title：Journal of atherosclerosis and thrombosis

authors： Nishiwaki Y,Michikawa T,Takebayashi T,Nitta H,Iso H,Inoue M,Tsugane S,Japan Public Health Center-based Prospective Study Group.

更新日期：2013-01-01 00:00:00

abstract：:Elevated resting heart rate (HR) is associated with hypertension in addition to or similar to increased incidence of cardiovascular morbidity and mortality. Subjects with high HR exhibit the characteristic features of insulin resistance syndrome. Sympathetic overactivity underlies this clinical condition. However, the...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hasegawa T,Watase H

更新日期：2003-01-01 00:00:00

abstract：AIMS:The clinical implications of stiffness of the carotid artery (CA) have not been fully clarified in the prediction of coronary artery disease (CAD), although intima-media thickness (IMT) has been established as a surrogate marker. We examined the associations of stiffness parameter beta (ST) and IMT with concurrent...

journal_title：Journal of atherosclerosis and thrombosis

authors： Lee E,Emoto M,Teramura M,Tsuchikura S,Ueno H,Shinohara K,Morioka T,Mori K,Koyama H,Shoji T,Okuno Y,Inaba M,Nishizawa Y

更新日期：2009-03-01 00:00:00

abstract：:We tried to investigate whether accumulation of visceral fat assessed by a simple but widely used ultrasonography was associated with common carotid atherosclerosis in women. The subjects were consecutively admitted in-patients whose body mass index was more than 22 kg/m2. Those with cardiorenal or nutritional disorde...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kawamoto R,Kajiwara T,Oka Y,Takagi Y

更新日期：2002-01-01 00:00:00

abstract：AIM:Ezetimibe, an inhibitor of cholesterol intestinal absorption, is a lipid lowering agent. However, anti-atherogenic effects of ezetimibe have not been fully elucidated. Therefore, the objective in this study was to clarify the vascular protective effects of ezetimibe in patients with hypercholesterolemia. METHODS:E...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kurobe H,Aihara K,Higashida M,Hirata Y,Nishiya M,Matsuoka Y,Kanbara T,Nakayama T,Kinoshita H,Sugano M,Fujimoto E,Kurobe A,Sugasawa N,Kitaichi T,Akaike M,Sata M,Matsumoto T,Kitagawa T

更新日期：2011-01-01 00:00:00

abstract：AIM:To investigatethe association of plasma epoxyeicosatrienoic acids (EETs) with early neurologic deterioration (END), and whether EETs are mediated by EPHX2 variants in patients with minor ischemic stroke (MIS). METHOD:This was a prospective, multi-center observational study in patients with acute MIS in the Chinese...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yi X,Lin J,Li J,Zhou Q,Han Z

更新日期：2017-12-01 00:00:00

abstract：AIMS:Fasting and postprandial hypertriglyceridemia (PHTG) are caused by the accumulation of triglyceride (TG)-rich lipoproteins and their remnants, which have atherogenic effects. Fibrates can improve fasting and PHTG; however, reduction of remnants is clinically needed to improve health outcomes. In the current study,...

journal_title：Journal of atherosclerosis and thrombosis

authors： Sairyo M,Kobayashi T,Masuda D,Kanno K,Zhu Y,Okada T,Koseki M,Ohama T,Nishida M,Sakata Y,Yamashita S

更新日期：2018-02-01 00:00:00

abstract：AIM:Individuals with type 2 diabetes are at high risk for cardiovascular events; however, a modality that could reduce risk has not been fully evaluated. We examined the annual incidence rate of cardiovascular events in asymptomatic Japanese diabetic patients who underwent gated myocardial perfusion single-photon compu...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yamasaki Y,Katakami N,Kaneto H,Nakajima K,Kusuoka H,Kashiwagi A,Nishimura T

更新日期：2013-01-01 00:00:00

abstract：AIM:Angiotensin-converting enzyme inhibitors (ACEIs) have been shown to block matrix metalloproteinase (MMP)-9 activity, which plays a role in atherogenesis. MMP-9 activity of macrophages is increased during foam cell formation. To investigate the contribution of ACEIs to foam cell formation, we studied the effects of ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kojima C,Ino J,Ishii H,Nitta K,Yoshida M

更新日期：2010-02-01 00:00:00

abstract：:To determine the recent serum lipid levels in the general Japanese population and trends in their changes over the past 30 years, a nationwide survey of serum lipid levels was conducted in 39 institutes from various districts around Japan. The total number of subjects were 34,815, consisting of 20,279 men and 14,536 w...

journal_title：Journal of atherosclerosis and thrombosis

authors：

更新日期：1996-01-01 00:00:00

abstract：:Dysregulation of adipose tissue-derived bioactive molecules, termed adipokines, is recognized as common ground for insulin resistance and metabolic syndrome associated with obesity. However, adipokine dysregulation is paradoxically associated with lipodystrophy and lipoatrophy with aging. In familial partial lipodystr...

journal_title：Journal of atherosclerosis and thrombosis

authors： Arai Y,Takayama M,Abe Y,Hirose N

更新日期：2011-01-01 00:00:00

abstract：AIM:We examined the effects of mild hyperbaric oxygen on the properties of the soleus muscle in rats with metabolic syndrome. METHODS:Five-week-old metabolic syndrome (SHR/NDmcr-cp, cp/cp) rats were divided into normobaric (CP) and mild hyperbaric oxygen (CP-H) groups (n=5/group). In addition, 5-week-old Wistar rats w...

journal_title：Journal of atherosclerosis and thrombosis

authors： Takemura A,Ishihara A

更新日期：2017-01-01 00:00:00

abstract：:Heparin cofactor II (HCII) specifically inhibits thrombin action at the site of vascular wall injury. We encountered a congenital HCII deficiency patient with advanced multiple atherosclerotic lesions. This patient led us to conduct clinical studies to examine the role of HCII against atherosclerosis. We found that th...

journal_title：Journal of atherosclerosis and thrombosis

authors： Aihara K,Azuma H,Akaike M,Sata M,Matsumoto T

更新日期：2009-10-01 00:00:00