Abstract:
AIM:A novel device has been developed for measuring the cardio-ankle vascular index (CAVI) as an indicator of arterial stiffness. In this study, we evaluated the effect of pitavastatin on CAVI in type 2 diabetic patients. METHODS:Forty-five type 2 diabetes mellitus patients with low-density lipoprotein cholesterolemia were enrolled and treated with pitavastatin 2 mg/day for 12 months. Before and after pitavastatin administration, HbA1c, serum lipids, serum malondialdehyde-LDL (MDA-LDL), urinary 8-hydroxy- 2'-deoxyguanosine (8-OHdG) and CAVI were measured. RESULTS:After pitavastatin treatment for 12 months, significant decreases in 8-OHdG, MDA-LDL and CAVI were observed. DeltaCAVI significantly correlated with DeltaMDA-LDL. CONCLUSIONS:In type 2 diabetic patients, pitavastatin may have an oxidative stress-reducing effect, especially in a state of enhanced oxidative stress, and CAVI may be useful as a routine test for the diagnosis and therapeutic monitoring of atherosclerosis.
journal_name
J Atheroscler Thrombjournal_title
Journal of atherosclerosis and thrombosisauthors
Miyashita Y,Endo K,Saiki A,Ban N,Yamaguchi T,Kawana H,Nagayama D,Ohira M,Oyama T,Shirai Kdoi
10.5551/jat.281subject
Has Abstractpub_date
2009-10-01 00:00:00pages
539-45issue
5eissn
1340-3478issn
1880-3873pii
JST.JSTAGE/jat/281journal_volume
16pub_type
杂志文章,随机对照试验abstract:AIM:Epicardial adipose tissue (EAT) is implicated in the development of coronary atherosclerosis.We sought to investigate the association between the EAT thickness and presence of multivessel disease (MV) in patients with acute myocardial infarction (AMI). METHODS:We enrolled 45 consecutive patients with AMI who under...
journal_title:Journal of atherosclerosis and thrombosis
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abstract::Heparin cofactor II (HCII) specifically inhibits thrombin action at the site of vascular wall injury. We encountered a congenital HCII deficiency patient with advanced multiple atherosclerotic lesions. This patient led us to conduct clinical studies to examine the role of HCII against atherosclerosis. We found that th...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,评审
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更新日期:2009-10-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
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abstract:AIM:The importance of sarcopenia in cardiovascular diseases has been recently demonstrated. This study aims to examine whether skeletal muscle mass (SMM), an important component of sarcopenia, is associated with an increased risk of poor outcome in patients after ST-segment elevation myocardial infarction (STEMI). MET...
journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
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更新日期:2009-03-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
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更新日期:2016-09-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
abstract:AIM:The prognostic value of homocysteine (HCY) in patients with coronary artery diseases (CAD) is still controversial. The objective of this study was to investigate whether elevated HCY level at admission predict long-term outcomes in patients after percutaneous coronary interventions (PCI) with coronary artery stenti...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 临床试验,杂志文章
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
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更新日期:2003-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
abstract:AIM:The purpose of this study was to evaluate the efficacy and safety of LIVALO tablets (pitavastatin) in Japanese male children with heterozygous familial hypercholesterolemia (FH). METHODS:A multicenter, randomized, double-blind, parallel study was conducted in 14 male children 10-15 years of age with heterozygous F...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of atherosclerosis and thrombosis
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abstract::The constellation of metabolic abnormalities including centrally distributed obesity, decreased high-density lipoprotein cholesterol (HDL-C), elevated triglycerides, elevated blood pressure (BP), and hyperglycaemia is known as the metabolic syndrome. Associated with a 3 fold and 2 fold increase in type 2 diabetes and ...
journal_title:Journal of atherosclerosis and thrombosis
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更新日期:2005-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
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更新日期:2012-01-01 00:00:00