Abstract:
AIM:Individuals with type 2 diabetes are at high risk for cardiovascular events; however, a modality that could reduce risk has not been fully evaluated. We examined the annual incidence rate of cardiovascular events in asymptomatic Japanese diabetic patients who underwent gated myocardial perfusion single-photon computed tomography (SPECT). METHODS:Asymptomatic patients (n= 485) aged ≥50 years and with either a maximal carotid artery intima-media thickness of ≥1.1 mm, or urinary albumin ≥30 mg/g creatinine, or at least two of abdominal obesity, low HDL cholesterol, high triglyceride levels and hypertension were evaluated at 50 institutions using gated SPECT with the stress-rest protocol and were followed up for three years. In the patients with summed stress scores (SSS) of ≥9, the initial high cardiovascular incidence rate in the first year declined significantly (p<0.001) from 21% to 2% during the second and third year. RESULTS:The incident rate was consistent among diabetics with low SSS during follow-up. Baseline LDL and non-HDL cholesterol levels significantly reduced (123±6.4 to 99±6.1 mg/dL; p<0.05) during the first year in diabetic patients with high SSS, but did not significantly change in diabetic patients with low (<9) SSS. CONCLUSION:The immediate improvement of lipid levels within one year correlated with the significant reduction in CVD events arising in diabetic patients with moderate or severe myocardial ischemia. Thus, rapidly lowering hyperlipidemia is very effective for patients with type 2 diabetes at high risk for cardiac events.
journal_name
J Atheroscler Thrombjournal_title
Journal of atherosclerosis and thrombosisauthors
Yamasaki Y,Katakami N,Kaneto H,Nakajima K,Kusuoka H,Kashiwagi A,Nishimura Tdoi
10.5551/jat.13474subject
Has Abstractpub_date
2013-01-01 00:00:00pages
330-5issue
4eissn
1340-3478issn
1880-3873pii
DN/JST.JSTAGE/jat/13474journal_volume
20pub_type
杂志文章abstract:AIM:Asymmetric dimethylarginine(ADMA) has recently been investigated as a risk marker for cardio- and cerebrovascular diseases. However, it is not currently known whether the ADMA levels are related to the risk of stroke in Japanese women. METHODS:We examined 192 Japanese women(mean age, 55±9 years, range, 40-80 years...
journal_title:Journal of atherosclerosis and thrombosis
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更新日期:2014-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
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abstract:AIM:Lipoprotein lipase protein exists in preheparin serum (preheparin LpL mass), even though lipoprotein lipase activity is rarely detected. Recent clinical studies have clarified that low preheparin LpL mass concentration is an important coronary risk factor. The aim of this study was to clarify the effect of telmisar...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.e547
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.4796
更新日期:2010-09-30 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
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更新日期:2009-04-01 00:00:00
abstract:AIM:Up-regulation of soluble CD40 ligand (sCD40L) and of monocyte chemoattractant protein-1 (MCP-1) has been found in diabetes and in patients with acute cerebral ischemia. We asked whether (i) the two molecules are similarly upregulated among non-lacunar and lacunar diabetic strokes and (ii) sCD40L and/or MCP-1 predic...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-05-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.12.240
更新日期:2005-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.33951
更新日期:2016-08-01 00:00:00
abstract::A 77-year-old woman with type II diabetes mellitus was admitted to our hospital in August/ 1995 with severe hyperlipidemia. She had taken feedings through a nasogastric tube with 1000 ml (1000 kcal) of Ensureliquid daily since 1993 because of the muscle weakness after rhabdomyolysis. Her serum total cholesterol was 51...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.10.321
更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2013-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.31526
更新日期:2016-06-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.3764
更新日期:2010-06-30 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.61960
更新日期:2021-01-22 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
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pub_type: 临床试验,杂志文章
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更新日期:2019-09-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
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doi:10.5551/jat1994.8.50
更新日期:2001-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
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更新日期:2006-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-02-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 临床试验,杂志文章
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更新日期:2007-02-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
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更新日期:2011-01-01 00:00:00
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更新日期:2015-01-01 00:00:00