Abstract:
AIMS:The present study aimed to determine the epidemiological aspects of medico-legal autopsies and manifestation of coronary atherosclerosis. METHODS:This was a cross sectional study involving 222 cases recruited from National Institute of Forensic Medicine (NIFM) Hospital Kuala Lumpur (HKL) and Department of Forensic Medicine Hospital Sungai Buloh (HSgB) for a period of 15 months, from December 2012 to April 2014. Sociodemographic and autopsy findings, including the cause and manner of death were documented. RESULTS:Male and female subjects aged 18-70 years were recruited. Males contributed to 86% of the total subjects and comprised 61% of young adults. Road traffic accidents were the primary cause of death, contributing almost 50% of the subjects. One third of the cases comprised of death due to natural causes, wherein almost 75% of the subjects within this category succumbed to sudden cardiac death. Coronary artery disease (CAD) contributed to 60% of the sudden cardiac death (SCD). Single and double-vessel diseases were the most common pattern of atherosclerosis. In almost 80% of CAD cases, atherosclerosis affected the left anterior descending artery (LAD). CONCLUSION:Cardiovascular diseases were the most significant natural cause of sudden death with a staggering figure of 75%. CAD was the single most commonly encountered pathology within the SCD. Most cases presented with single and double-vessel diseases, observed in all subjects, as well as the young adult population.
journal_name
J Atheroscler Thrombjournal_title
Journal of atherosclerosis and thrombosisauthors
Rahimi R,Singh MKC,Noor NM,Omar E,Noor SM,Mahmood MS,Abdullah N,Nawawi HMdoi
10.5551/jat.39107subject
Has Abstractpub_date
2018-05-01 00:00:00pages
405-409issue
5eissn
1340-3478issn
1880-3873journal_volume
25pub_type
杂志文章abstract:AIM:The INK4b-ARF-INK4a locus in the chromosome 9p21 region is known to play an important role in the development of atherosclerosis. The INK4/ARF transcript p16(INK4a) inhibits the activity of the cyclin-dependent kinases CDK4/CDK6 and arrests cell-cycle progression. CDK inhibitors also regulate G1/S phase progression...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.21774
更新日期:2014-01-01 00:00:00
abstract:AIMS:Adiponectin, an adipocyte-specific secretory protein, abundantly exists in the blood stream while its concentration paradoxically decreases in obesity. Hypoadiponectinemia is one of risks of cardiovascular diseases. However, impact of serum adiponectin concentration on acute ischemic myocardial damages has not bee...
journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,评审
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,评审
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更新日期:2010-09-30 00:00:00
abstract:AIM:Recent studies have suggested that hyperinsulinemia is associated with high cardiovascular risk. The purpose of this study was to assess the relationship between the serum insulin level and coronary artery calcification (CAC). METHODS:We performed a cross-sectional study of 582 consecutive and nondiabetic particip...
journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 临床试验,杂志文章
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更新日期:2007-02-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
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更新日期:2020-12-01 00:00:00
abstract:AIM:Homocysteine is associated with increased arterial resistance and eventually causes luminal reduction. The purpose of the present study was to evaluate an association between the plasma concentration of total homocysteine (tHcy) and stenosis or occlusion of the internal carotid artery (ICA) in patients with ischemi...
journal_title:Journal of atherosclerosis and thrombosis
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更新日期:2010-09-30 00:00:00
abstract:AIM:All health insurers in Japan are mandated to provide Specific Health Checkups and Specific Health Guidance (SHG) focusing on metabolic syndrome (MetS) in middle-aged adults, beginning in 2008; intensive HG for individuals who have abdominal obesity and two or more additional MetS risk factors, and motivational HG f...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00
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abstract::Although the human liver comprises approximately 2.8% of the body weight, it plays a central role in the control of energy metabolism. While the biochemistry of energy substrates such as glucose, fatty acids, and ketone bodies in the liver is well understood, many aspects of the overall control system for hepatic meta...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
abstract:AIM:Familial hypercholesterolemia (FH) is the most commonly encountered genetic condition that predisposes individuals to severe autosomal dominant lipid metabolism dysfunction. Although more than 75% of the European population has been scrutinized for FH-causing mutations, the genetic diagnosis proportion among Chines...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
abstract:AIM:Glucagon-like peptide-1 can reduce both postprandial plasma glucose (PG) and chylomicron (CM) levels in patients with type 2 diabetes. However, there have been no reports regarding the relationship between the postprandial metabolism of PG and CM. METHODS:Patients with type 2 diabetes who were admitted for glycemi...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,随机对照试验
doi:10.5551/jat.32409
更新日期:2017-02-01 00:00:00
abstract:AIM:A new antibody reacted with an epitope in Lp(a) that has undergone oxidation treatment, but is not present in native Lp(a), was developed. Thus, we determined serum oxidized Lp(a) concentration in healthy volunteers, and coronary artery disease (CAD), diabetes mellitus (DM), and hypertensive patients. METHODS:We m...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.no224
更新日期:2009-08-01 00:00:00
abstract:AIMS:Renal dysfunction is a major public health problem, but there have been few investigations of the relationship between serum high molecular weight (HMW) adiponectin and renal function in Japanese community-dwelling adults. METHODS:We randomly recruited a sample of 1,849 adult Japanese (793 men aged 60 ± 14 (mean ...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.5124
更新日期:2010-11-27 00:00:00
abstract:AIM:It remains uncertain whether chronic exposure to particulate air pollution is associated with increased mortality in Japan because Japan has a different distribution pattern of cardiovascular disease and its risk factors compared to Western countries. We investigated the association between long-term exposure to pa...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,随机对照试验
doi:10.5551/jat.9506
更新日期:2012-01-01 00:00:00
abstract::Normal and alloxan diabetic rats were kept on a 0.25% cholesterol diet for 12 months and the changes in serum cholesterol levels, and fecal excretion of sterols and bile acids were examined to elucidate the influence of changes in bile acid metabolism on manifestations of hypercholesterolemia and development of athero...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat1994.3.52
更新日期:1996-01-01 00:00:00
abstract::To determine the recent serum lipid levels and other serum variables in the general Japanese population and trends in their changes over the past 40 years, a nationwide survey of serum lipid levels was conducted in 36 institutes from various districts around Japan in 2000. The total number of subjects was 12,839, aged...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,多中心研究
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更新日期:2005-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.22582
更新日期:2014-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,评审
doi:10.5551/jat1994.5.66
更新日期:1998-01-01 00:00:00
abstract:AIM:The arterial pressure-volume index (API) and arterial velocity-pulse index (AVI) are novel measurement indices of arterial stiffness. This study was performed to examine the screening validity of the API and AVI for preclinical atherosclerosis in Japanese community-dwelling adults. METHODS:We conducted a cross-sec...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
abstract::The agarose gel electrophoresis and differential staining system is an easy and quick method for analyzing the serum lipid composition of each lipoprotein fraction. It has been reported in adults that measured values obtained by this method strongly correlated with those obtained by ultracentrifugation. The aim of thi...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.13.227
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat1994.2.122
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abstract:AIM:A positive association between metabolic syndrome (MetS) and periodontal status has recently been noted. However, no study has evaluated the relationship by sex and in a general urban population using the uniform definition proposed in the 2009 Joint Interim Statement. The aim of this study was to clarify the relat...
journal_title:Journal of atherosclerosis and thrombosis
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abstract:AIM:To evaluate whether plaque scoring measurements are able to track changes in atherosclerotic plaque burden over time and to study whether this is affected by lipid-lowering therapy. METHODS:Data used were from METEOR (Measuring Effects on Intima-Media Thickness: an Evaluation Of Rosuvastatin), a randomized control...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,随机对照试验
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更新日期:2011-01-01 00:00:00