Abstract:
AIM:Homocysteine is associated with increased arterial resistance and eventually causes luminal reduction. The purpose of the present study was to evaluate an association between the plasma concentration of total homocysteine (tHcy) and stenosis or occlusion of the internal carotid artery (ICA) in patients with ischemic stroke. METHODS:In total, 391 patients with ischemic stroke were evaluated from March 2007 to February 2008. The criterion for ICA stenosis or occlusion was set at greater than 50% luminal narrowing or complete obstruction in at least one ICA. Patients were assigned to one of three groups: normal ICA, ICA stenosis, and ICA occlusion. RESULTS:ICA stenosis was found in 71 patients, whereas ICA occlusion in 22 patients (18.2% and 5.6%, respectively). Plasma tHcy was significantly higher in groups with ICA stenosis/occlusion with the highest value of ICA occlusion (14.6 ± 1.0 µmol/L, p = 0.025). A 1 µmol/L increase of tHcy showed an adjusted odds ratio of 1.12 (95% confidence intervals, 1.03-1.24, p=0.008) for ICA occlusion in a multivariate logistic model adjusted for all possible confounders, including age, sex, vascular risk factors, and stroke classifications. CONCLUSION:Elevated levels of tHcy were significantly associated with the ICA occlusion, independent of vascular risk factors and stroke subtypes.
journal_name
J Atheroscler Thrombjournal_title
Journal of atherosclerosis and thrombosisauthors
Jeong SK,Seo JY,Cho YIdoi
10.5551/jat.4796subject
Has Abstractpub_date
2010-09-30 00:00:00pages
963-9issue
9eissn
1340-3478issn
1880-3873pii
JST.JSTAGE/jat/4796journal_volume
17pub_type
杂志文章abstract:AIM:Although the InnovaTM self-expanding nitinol stent (Boston Scientific, Marlborough, MA) exhibits acceptable performance in long-term safety and efficacy when used for the treatment of femoropopliteal (FP) lesions, clinical outcomes following its implantation have not been systematically studied in real-world settin...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,多中心研究
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abstract:AIM:It remains uncertain whether chronic exposure to particulate air pollution is associated with increased mortality in Japan because Japan has a different distribution pattern of cardiovascular disease and its risk factors compared to Western countries. We investigated the association between long-term exposure to pa...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,随机对照试验
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abstract::Zetia (ezetimibe) is a selective cholesterol absorption inhibitor, which potently inhibits the absorption of biliary and dietary cholesterol from the small intestine without affecting the absorption of fat-soluble vitamins, triglycerides or bile acids. Ezetimibe reduces the small intestinal enterocyte uptake and absor...
journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
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doi:10.5551/jat.10108
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.34215
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abstract::Normal and alloxan diabetic rats were kept on a 0.25% cholesterol diet for 12 months and the changes in serum cholesterol levels, and fecal excretion of sterols and bile acids were examined to elucidate the influence of changes in bile acid metabolism on manifestations of hypercholesterolemia and development of athero...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat1994.3.52
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,随机对照试验
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更新日期:2009-10-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
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abstract:AIM:Moderate alcohol consumption appears to confer some protection against coronary heart disease, which is related to an increase in high-density lipoprotein cholesterol (HDL-C). The genotype of aldehyde dehydrogenase 2 (ALDH2) is closely related to alcohol metabolism but a relationship between ALDH2 genotypes and HDL...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.e542
更新日期:2008-08-01 00:00:00
abstract::Both hyperthyroidism and hypothyroidism affect the cardiovascular system. Hypothyroidism is known to be associated with enhanced atherosclerosis and ischemic heart diseases. The accelerated atherosclerosis in the hypothyroid state has been traditionally ascribed to atherogenic lipid profile, diastolic hypertension, an...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
abstract:AIM:Glucagon-like peptide-1 can reduce both postprandial plasma glucose (PG) and chylomicron (CM) levels in patients with type 2 diabetes. However, there have been no reports regarding the relationship between the postprandial metabolism of PG and CM. METHODS:Patients with type 2 diabetes who were admitted for glycemi...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,随机对照试验
doi:10.5551/jat.32409
更新日期:2017-02-01 00:00:00
abstract::Hypertriglyceridemia is often associated with small dense low density lipoprotein (LDL), elevated remnants, and decreased high density lipoprotein (HDL)-cholesterol (C), which comprise the dyslipidemic triad. The objective of this study was to investigate the effect of fenofibrate on the lipoprotein subfraction profil...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 临床试验,杂志文章
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更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.5551/jat.7922
更新日期:2011-01-01 00:00:00
abstract::Sitosterolemia is a rare, autosomal recessive inherited sterol storage disease associated with high tissue and serum plant sterol concentrations, caused by mutations in the adenosine triphosphate-bind-ing cassette (ABC) transporter ABCG5 or ABCG8 genes. Markedly increased serum concentration of plant sterols. such as ...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,评审
doi:10.5551/jat.4614
更新日期:2010-09-30 00:00:00
abstract::A 77-year-old woman with type II diabetes mellitus was admitted to our hospital in August/ 1995 with severe hyperlipidemia. She had taken feedings through a nasogastric tube with 1000 ml (1000 kcal) of Ensureliquid daily since 1993 because of the muscle weakness after rhabdomyolysis. Her serum total cholesterol was 51...
journal_title:Journal of atherosclerosis and thrombosis
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doi:10.5551/jat.10.321
更新日期:2003-01-01 00:00:00
abstract:AIM:Central pulse pressure and measures of arterial stiffness (augmentation index (AIx) and aortic pulse wave velocity (PWV)) predict morbidity and mortality in patients with stage 2-4 chronic kidney disease (CKD). Although statin therapy may be of vascular benefit in patients with CKD, the long-term effect of statins ...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章,随机对照试验
doi:10.5551/jat.2683
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abstract::Arterial stiffness is increased in type 2 diabetes mellitus, and diabetes preferentially affects arterial stiffness of the central (elastic, capacitive) over peripheral (muscular, conduit) arteries. We hypothesized that arterial stiffness of the central artery may be more closely associated with ischemic heart disease...
journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
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更新日期:2008-10-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat.9589
更新日期:2012-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
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更新日期:2020-10-02 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
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更新日期:2013-01-01 00:00:00