Altered bile acid metabolism related to atherosclerosis in alloxan diabetic rats.

abstract：:We now have discovered and characterized a novel multi-domain protein and classified it as a member of the LDL receptor gene family. The approximately 250 kDa membrane protein, termed LR11, highly conserved in man, rabbit and chicken, contains a cluster of 11 LDL receptor ligand binding repeats, a group of 5 LDL recep...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yamazaki H,Bujo H,Saito Y

更新日期：1997-01-01 00:00:00

abstract：AIM:A novel device has been developed for measuring the cardio-ankle vascular index (CAVI) as an indicator of arterial stiffness. In this study, we evaluated the effect of pitavastatin on CAVI in type 2 diabetic patients. METHODS:Forty-five type 2 diabetes mellitus patients with low-density lipoprotein cholesterolemia...

journal_title：Journal of atherosclerosis and thrombosis

authors： Miyashita Y,Endo K,Saiki A,Ban N,Yamaguchi T,Kawana H,Nagayama D,Ohira M,Oyama T,Shirai K

更新日期：2009-10-01 00:00:00

abstract：AIM:The purpose of this study is to investigate the impact of arterial stiffness assessed using Cardio-ankle Vascular Index (CAVI) on long-term outcome after acute coronary syndrome (ACS). METHODS:A total of 387 consecutive patients (324 males; age, 64±11 years) with ACS were enrolled. We examined CAVI and brachial-an...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kirigaya J,Iwahashi N,Tahakashi H,Minamimoto Y,Gohbara M,Abe T,Akiyama E,Okada K,Matsuzawa Y,Maejima N,Hibi K,Kosuge M,Ebina T,Tamura K,Kimura K

更新日期：2020-07-01 00:00:00

abstract：AIMS:Statins not only reduce low-density lipoprotein (LDL) cholesterol, but also prevent the progression of kidney dysfunction. Ezetimibe, a cholesterol-absorption inhibitor, also lowers LDL cholesterol levels when added to statins; however, the effect of add-on ezetimibe on kidney function has had conflicting results....

journal_title：Journal of atherosclerosis and thrombosis

authors： Kinouchi K,Ichihara A,Bokuda K,Morimoto S,Itoh H

更新日期：2013-01-01 00:00:00

abstract：AIM:Myriad biological effects of leptin may lead to broad therapeutic applications for various metabolic diseases, including diabetes and its complications; however, in contrast to its anorexic effect, the molecular mechanisms underlying adipopenic and glucose-lowering effects of leptin have not been fully understood. ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Takanashi M,Taira Y,Okazaki S,Takase S,Kimura T,Li CC,Xu PF,Noda A,Sakata I,Kumagai H,Ikeda Y,Iizuka Y,Yahagi N,Shimano H,Osuga JI,Ishibashi S,Kadowaki T,Okazaki H

更新日期：2017-11-01 00:00:00

abstract：AIM:Existing evidence suggests that endothelial lipase (EL) plays an important role in high-densitylipoprotein (HDL) metabolism. Because rabbits are a useful animal model for the study of human lipid metabolism and atherosclerosis, we characterized rabbit EL (rEL) expression and investigated its relationship with plasm...

journal_title：Journal of atherosclerosis and thrombosis

authors： Zhang J,Yu Y,Nakamura K,Koike T,Waqar AB,Zhang X,Liu E,Nishijima K,Kitajima S,Shiomi M,Qi Z,Yu J,Graham MJ,Crooke RM,Ishida T,Hirata K,Hurt-Camejo E,Chen YE,Fan J

更新日期：2012-01-01 00:00:00

abstract：AIM:High density lipoprotein (HDL) and its apolipoproteins can promote cholesterol efflux from macrophage foam cells via the ATP-binding cassette transporter A1 (ABCA1), ABCG1, and scavenger receptor class B type I (SR-BI). Liver X receptors (LXRs) operate as cholesterol sensors which may protect from cholesterol overl...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hu YW,Wang Q,Ma X,Li XX,Liu XH,Xiao J,Liao DF,Xiang J,Tang CK

更新日期：2010-05-01 00:00:00

abstract：:Lecithin-cholesterol acyltransferase (LCAT) is an important enzyme involved in the esterification of cholesterol. Here, we report a novel point mutation in the LCAT gene of a 63-year-old female with characteristics of classic familial LCAT deficiency. The patient's clinical manifestations included corneal opacity, mil...

journal_title：Journal of atherosclerosis and thrombosis

authors： Wang XL,Osuga J,Tazoe F,Okada K,Nagashima S,Takahashi M,Ohshiro T,Bayasgalan T,Yagyu H,Okada K,Ishibashi S

更新日期：2011-01-01 00:00:00

abstract：:We have investigated whether the oral administration of vitamin C could prevent smoking-induced acceleration of arterial stiffness in healthy volunteers. Subjects were pretreated with 2 g vitamin C and their heart rate (HR), mean blood pressure (MBP), and brachial-ankle pulse wave velocity (baPWV) were measured before...

journal_title：Journal of atherosclerosis and thrombosis

authors： Katayama Y,Shige H,Yamamoto A,Hirata F,Yasuda H

更新日期：2004-01-01 00:00:00

abstract：AIM:Angiotensin (Ang) II-induced abdominal aortic aneurysm (AAA) in apoE-deficient mice has been used as a model of human AAA, but it has been unclear why the progression of AAA continues after stopping the Ang II infusion. The involvement of vascular Ang II-forming enzymes in the progression of AAA was studied. METHO...

journal_title：Journal of atherosclerosis and thrombosis

authors： Inoue N,Muramatsu M,Jin D,Takai S,Hayashi T,Katayama H,Kitaura Y,Tamai H,Miyazaki M

更新日期：2009-06-01 00:00:00

abstract：AIM:Associations between long-term exposure to particulate matter (PM) and increased cardiovascular mortality have been reported, but few studies have investigated the associated incidence of cardiovascular disease, and none involved men. METHODS:We used data on 78,057 participants (37,121 men, 40,936 women) to examin...

journal_title：Journal of atherosclerosis and thrombosis

authors： Nishiwaki Y,Michikawa T,Takebayashi T,Nitta H,Iso H,Inoue M,Tsugane S,Japan Public Health Center-based Prospective Study Group.

更新日期：2013-01-01 00:00:00

abstract：AIM:Heterozygous patients with familial hypercholesterolemia (FH) are known to be associated with a high risk of coronary artery disease (CAD), which is a major determinant of their clinical outcome. The prognosis of heterozygous FH patients substantially varies, being dependent on the level of their CAD risk, and thei...

journal_title：Journal of atherosclerosis and thrombosis

authors： Sugisawa T,Okamura T,Makino H,Watanabe M,Kishimoto I,Miyamoto Y,Iwamoto N,Yamamoto A,Yokoyama S,Harada-Shiba M

更新日期：2012-01-01 00:00:00

abstract：AIM:The ankle-brachial index(ABI) is an easy-to-use, non-invasive and reliable diagnostic tool for assessing peripheral arterial occlusive disease(PAOD). The CHADS2(congestive heart failure, hypertension, age ≧75 years, diabetes, prior stroke) score is a simple and popular clinical parameter that is used to assess the ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hsu PC,Lin TH,Lee WH,Chu CY,Chiu CA,Lee HH,Su HM,Voon WC,Lai WT,Sheu SH

更新日期：2014-01-01 00:00:00

abstract：AIM:Homocysteine is associated with increased arterial resistance and eventually causes luminal reduction. The purpose of the present study was to evaluate an association between the plasma concentration of total homocysteine (tHcy) and stenosis or occlusion of the internal carotid artery (ICA) in patients with ischemi...

journal_title：Journal of atherosclerosis and thrombosis

authors： Jeong SK,Seo JY,Cho YI

更新日期：2010-09-30 00:00:00

abstract：AIM:Although distal embolization during percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) deteriorates cardiac function, whether distal protection (DP) can improve prognosis is still controversial. We investigated whether a filter-type DP device, Filtrap®, could improve long-term outcomes a...

journal_title：Journal of atherosclerosis and thrombosis

authors： Teramoto R,Sakata K,Miwa K,Matsubara T,Yasuda T,Inoue M,Okada H,Kanaya H,Kawashiri MA,Yamagishi M,Hayashi K

更新日期：2016-12-01 00:00:00

abstract：:The effects of combination therapy of angiotensin II receptor blockers (ARBs) and a calcium antagonist, benidipine hydrochloride, on glucose and lipid metabolism and pulse pressure were studied in elderly hypertensive patients with type 2 diabetes mellitus. Twenty-five hypertensive diabetic patients aged 65 years or o...

journal_title：Journal of atherosclerosis and thrombosis

authors： Sasaki H,Kanai S,Oyama T,Miyashita Y,Yamamura S,Shirai K

更新日期：2006-06-01 00:00:00

abstract：:The purpose of the present study was to investigate the relationship between insulin resistance, sex hormones and sex hormone-binding globulin (SHBG) in regard to the serum lipid and lipoprotein profiles of 82 Japanese postmenopausal women. A multiple regression analysis for lipids, lipoproteins, and apoproteins as de...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kumagai S,Kai Y,Sasaki H

更新日期：2001-01-01 00:00:00

abstract：AIM:The clinical relevance of the suggested pleiotropic effects of hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) is controversial. Aggressive statins effectively reduce lipid levels, but whether their other effects are more powerful than those of regular statins is unknown. METHODS:We enrolled 32 pat...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hoshiga M,Arishiro K,Nakakoji T,Miyazaki N,Negoro N,Okabe T,Kohbayashi E,Ishihara T,Hanafusa T

更新日期：2010-07-30 00:00:00

abstract：AIMS:Considering that cerebral infarction (CI) may share a common etiological basis with coronary artery disease (CAD), we evaluated six CAD-related single-nucleotide polymorphisms (SNPs) on 9p21 for investigating the effect of 9p21 on CI or carotid plaque in the Chinese Han population. METHODS:Altogether, 528 patient...

journal_title：Journal of atherosclerosis and thrombosis

authors： Lu Z,Zhang Y,Maimaiti Y,Feng Y,Sun J,Zhuang J,Zeng L,Fu Y

更新日期：2015-01-01 00:00:00

abstract：:We investigated the mechanism by which 7-ketocholesterol damages vascular smooth muscle cells and the protective effect of the hydroxymethyl glutary CoA reductase inhibitor, pravastatin on it. When 7-ketocholesterol (50 micromol/L) was added to cultured human vascular smooth muscle cells, the extent of cell detachment...

journal_title：Journal of atherosclerosis and thrombosis

authors： Miyashita Y,Ozaki H,Koide N,Otsuka M,Oyama T,Itoh Y,Mastuzaka T,Shirai K

更新日期：2002-01-01 00:00:00

abstract：AIM:Central pulse pressure and measures of arterial stiffness (augmentation index (AIx) and aortic pulse wave velocity (PWV)) predict morbidity and mortality in patients with stage 2-4 chronic kidney disease (CKD). Although statin therapy may be of vascular benefit in patients with CKD, the long-term effect of statins ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Fassett RG,Robertson IK,Ball MJ,Geraghty DP,Sharman JE,Coombes JS

更新日期：2010-03-31 00:00:00

abstract：:The proliferation of vascular smooth muscle cells (VSMCs) can contribute to a variety of pathological states, including atherosclerosis and post-angioplasty restenosis. The p21(WAF1) cyclin-dependent kinase inhibitor regulates cell-cycle progression, senescence, and differentiation in injured blood vessels. Histone de...

journal_title：Journal of atherosclerosis and thrombosis

authors： Okamoto H,Fujioka Y,Takahashi A,Takahashi T,Taniguchi T,Ishikawa Y,Yokoyama M

更新日期：2006-08-01 00:00:00

abstract：:The signaling and functions of the Endothelial Differentiation Gene (EDG) family of G protein-coupled receptors have been extensively elucidated. All the members of EDG family were shown to be receptors for lysosphingolipids or lysophospholipids. EDG-1, the prototype of EDG family receptors, is a high affinity recepto...

journal_title：Journal of atherosclerosis and thrombosis

authors： Ozaki H,Hla T,Lee MJ

更新日期：2003-01-01 00:00:00

abstract：AIM:To determine the effects of exercise training on total and high molecular weight (HMW) adiponectin and adiponectin oligomeric distribution. METHODS:A randomized parallel-design study (n=53; 40 women and 13 men; age range, 32?65 years) was conducted at a fitness club between April 2006 and July 2007. Participants w...

journal_title：Journal of atherosclerosis and thrombosis

authors： Ando D,Hosaka Y,Suzuki K,Yamagata Z

更新日期：2009-01-01 00:00:00

abstract：:Heparin cofactor II (HCII) specifically inhibits thrombin action at the site of vascular wall injury. We encountered a congenital HCII deficiency patient with advanced multiple atherosclerotic lesions. This patient led us to conduct clinical studies to examine the role of HCII against atherosclerosis. We found that th...

journal_title：Journal of atherosclerosis and thrombosis

authors： Aihara K,Azuma H,Akaike M,Sata M,Matsumoto T

更新日期：2009-10-01 00:00:00

abstract：AIM:The prospective, randomized, multicenter Myocardial Ischemia Treated with Percutaneous Coronary Intervention and Plaque Regression by Lipid Lowering & Blood Pressure Controlling assessed by Intravascular Ultrasonography (MILLION) study demonstrated that combined treatment with atorvastatin and amlodipine enhanced c...

journal_title：Journal of atherosclerosis and thrombosis

authors： Sakata K,Gamou T,Tada H,Hayashi K,Ino H,Yamagishi M,Masa-aki Kawashiri.,behalf of the MILLION Study Group.

更新日期：2019-05-01 00:00:00

abstract：AIM:Aim of this study was to directly detect increased permeability of vascular lesions by magnetic resonance imaging. METHODS:A novel contrast medium with a mean hydrodynamic diameter of 100 nm was prepared from monodispersed iron colloids incorporated into micelles of block copolymers composed of polyethylene glycol...

journal_title：Journal of atherosclerosis and thrombosis

authors： Imai Y,Kaneko E,Asano T,Kumagai M,Ai M,Kawakami A,Kataoka K,Shimokado K

更新日期：2007-04-01 00:00:00

abstract：AIM:Familial hypercholesterolemia (FH) is the most commonly encountered genetic condition that predisposes individuals to severe autosomal dominant lipid metabolism dysfunction. Although more than 75% of the European population has been scrutinized for FH-causing mutations, the genetic diagnosis proportion among Chines...

journal_title：Journal of atherosclerosis and thrombosis

authors： Wang H,Yang H,Liu Z,Cui K,Zhang Y,Zhang Y,Zhao K,Yin K,Li W,Zhou Z

更新日期：2020-12-01 00:00:00

abstract：AIM:To examine the association between renal vasculature changes and generalized atherosclerosis using autopsy cases. METHODS:We histologically examined 107 autopsy patients(mean age, 68.4 years; 64% men; 81% non-CVD) to investigate the association between renal vasculature changes and generalized atherosclerosis. We ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Iwakiri T,Sato Y,Matsuura Y,Hatakeyama K,Marutsuka K,Yamashita A,Fujimoto S,Kitamura K,Asada Y

更新日期：2014-01-01 00:00:00

abstract：:Measurement of arterial stiffness in routine medical practice is important to assess the progression of arteriosclerosis. So far, many parameters have been proposed to quantitatively represent arterial stiffness. Among these, pulse wave velocity (PWV) has been most frequently applied to clinical medicine because those...

journal_title：Journal of atherosclerosis and thrombosis

authors： Saiki A,Sato Y,Watanabe R,Watanabe Y,Imamura H,Yamaguchi T,Ban N,Kawana H,Nagumo A,Nagayama D,Ohira M,Endo K,Tatsuno I

更新日期：2016-01-01 00:00:00