Abstract:
:We have investigated whether the oral administration of vitamin C could prevent smoking-induced acceleration of arterial stiffness in healthy volunteers. Subjects were pretreated with 2 g vitamin C and their heart rate (HR), mean blood pressure (MBP), and brachial-ankle pulse wave velocity (baPWV) were measured before and after smoking. Smoking significantly increased the HR, MBP, baPWV (13, 6.4, 7.0%). Vitamin C treatment significantly reduced the smoking-induced elevation in baPWV at 0 min (- 58.5%, p = 0.0002) without affecting HR or MBP. These findings suggest that oral vitamin C treatment prevents smoking-induced acceleration in arterial stiffness through reducing endothelial dysfunction.
journal_name
J Atheroscler Thrombjournal_title
Journal of atherosclerosis and thrombosisauthors
Katayama Y,Shige H,Yamamoto A,Hirata F,Yasuda Hdoi
10.5551/jat.11.354subject
Has Abstractpub_date
2004-01-01 00:00:00pages
354-7issue
6eissn
1340-3478issn
1880-3873pii
JST.JSTAGE/jat/11.354journal_volume
11pub_type
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