The metabolic syndrome: a global public health problem and a new definition.

abstract：AIM:We have conducted medical surveys on two Japanese populations (Japanese Americans living in the US and native Japanese living in Japan) to investigate the impact of westernization of lifestyles on diseases in Japanese people. A 1998 survey revealed that the progression of carotid intima-media wall thickness (IMT) w...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kubota M,Yoneda M,Watanabe H,Egusa G

更新日期：2017-10-01 00:00:00

abstract：AIM:Epicardial adipose tissue (EAT) may be associated with arrhythmogenesis. P-wave indices such as P-wave dispersion and P-wave variation indicated a slowed conduction velocity within the atria. This study investigated the effect of dapagliflozin on EAT volume and P-wave indices. METHODS:In the present ad hoc analysi...

journal_title：Journal of atherosclerosis and thrombosis

authors： Sato T,Aizawa Y,Yuasa S,Fujita S,Ikeda Y,Okabe M

更新日期：2020-12-01 00:00:00

abstract：AIMS:Type 2 diabetes mellitus (T2DM) is no longer regarded as a coronary risk equivalent, and heterogeneity of cardiovascular risk exists, suggesting that further risk stratification should be mandatory. This study aimed to determine the prevalence and clinical predictors of coronary artery calcium (CAC) score, and eva...

journal_title：Journal of atherosclerosis and thrombosis

authors： Lei MH,Wu YL,Chung SL,Chen CC,Chen WC,Hsu YC

更新日期：2020-11-07 00:00:00

abstract：AIM:The arterial pressure-volume index (API) and arterial velocity-pulse index (AVI) are novel measurement indices of arterial stiffness. This study was performed to examine the screening validity of the API and AVI for preclinical atherosclerosis in Japanese community-dwelling adults. METHODS:We conducted a cross-sec...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yamanashi H,Koyamatsu J,Nagayoshi M,Shimizu Y,Kawashiri SY,Kondo H,Fukui S,Tamai M,Maeda T

更新日期：2018-09-01 00:00:00

abstract：:Inflammation and oxidative stress play key roles in atherosclerotic plaque instability, and plaque rupture/erosion and subsequent thrombus formation constitute the principal mechanisms of total vessel occlusion and acute ST-elevation myocardial infarction (STEMI). Plaque disruption triggers the formation of initial pl...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yunoki K,Naruko T,Sugioka K,Inaba M,Itoh A,Haze K,Yoshiyama M,Ueda M

更新日期：2013-01-01 00:00:00

abstract：AIM:The purpose of this study was to evaluate the efficacy and safety of LIVALO tablets (pitavastatin) in Japanese male children with heterozygous familial hypercholesterolemia (FH). METHODS:A multicenter, randomized, double-blind, parallel study was conducted in 14 male children 10-15 years of age with heterozygous F...

journal_title：Journal of atherosclerosis and thrombosis

authors： Harada-Shiba M,Arisaka O,Ohtake A,Okada T,Suganami H,NK-104-PH 01 study registration group.

更新日期：2016-01-01 00:00:00

abstract：AIM:Withholding effective treatment is clinically prevalent. The CEntralized Pan-Asian survey on tHE Under-treatment of hypercholeSterolemia (CEPHEUS-PA) indicated suboptimal low-density lipoprotein cholesterol (LDL-C) goal attainment in Taiwan, which may be attributable to clinical inertia. We herein analyzed the Taiw...

journal_title：Journal of atherosclerosis and thrombosis

authors： Wang KL,Wu CH,Wang KF,Chang CC,Chen LC,Lu TM,Lin SJ,Chiang CE

更新日期：2014-01-01 00:00:00

abstract：AIM AND METHODS:The high-density lipoprotein 2 cholesterol (HDL2-C) to HDL3-C ratio is associated with insulin resistance, high-molecular-weight adiponectin (HMW-Ad), and metabolic syndrome (MetS) components and is useful for evaluating MetS in Japanese individuals. We investigated potential associations between change...

journal_title：Journal of atherosclerosis and thrombosis

authors： Moriyama K,Takahashi E

更新日期：2016-06-01 00:00:00

abstract：AIM:High density lipoprotein (HDL) and its apolipoproteins can promote cholesterol efflux from macrophage foam cells via the ATP-binding cassette transporter A1 (ABCA1), ABCG1, and scavenger receptor class B type I (SR-BI). Liver X receptors (LXRs) operate as cholesterol sensors which may protect from cholesterol overl...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hu YW,Wang Q,Ma X,Li XX,Liu XH,Xiao J,Liao DF,Xiang J,Tang CK

更新日期：2010-05-01 00:00:00

abstract：AIM:Macrophage migration inhibitory factor (MIF) is known as a pro-inflammatory cytokine that regulates a broad spectrum of inflammatory reactions. MIF is expressed in vascular smooth muscle cells (VSMCs), and inhibition of the progression of atherosclerosis was observed in MIF-deficient atherosclerotic mice. However, ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Okamoto T,Atsumi T,Shimizu C,Yoshioka N,Koike T

更新日期：2008-02-01 00:00:00

abstract：:The plasma levels of blood coagulation and fibrinolytic factors and the serum levels of lipids were measured in 62 subjects (22 normolipidemia and 40 hyperlipidemia) to investigate whether hyperlipidemia may affect the hemostatic system. Prothrombin, factors VII, IX and X were elevated in hyperlipidemic patients. The ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Morishita E,Jokaji H,Matsuda T

更新日期：1995-01-01 00:00:00

abstract：AIMS:Renal dysfunction is a major public health problem, but there have been few investigations of the relationship between serum high molecular weight (HMW) adiponectin and renal function in Japanese community-dwelling adults. METHODS:We randomly recruited a sample of 1,849 adult Japanese (793 men aged 60 ± 14 (mean ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kawamoto R,Tabara Y,Kohara K,Miki T,Abe M,Kusunoki T,Katoh T,Ohtsuka N

更新日期：2010-11-27 00:00:00

abstract：AIM:We investigated whether any seasonal variation is observed in the incidence, severity and prognosis of critical limb ischemia (CLI) requiring endovascular therapy. METHODS:We analyzed a multicenter database of 1,568 consecutive CLI cases undergoing primary endovascular therapy for infrainguinal lesions between Jul...

journal_title：Journal of atherosclerosis and thrombosis

authors： Takahara M,Iida O,Soga Y,Hirano K,Yamaoka T,Kawasaki D,Suzuki K,Suematsu N,Shintani Y,Miyashita Y,Kaneto H,Shimomura I

更新日期：2013-01-01 00:00:00

abstract：AIM:There are few data regarding associations between sleep duration and subclinical atherosclerosis in Japan. The aim of this study was to evaluate associations of self-reported sleep duration with calcification in the coronary arteries (CAC) and carotid intima media thickness (IMT) in Japanese men. METHODS:This was ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Suzuki S,Arima H,Miyazaki S,Fujiyoshi A,Kadota A,Takashima N,Hisamatsu T,Kadowaki S,Zaid M,Torii S,Horie M,Murata K,Miura K,Ueshima H,SESSA Research Group.

更新日期：2018-02-01 00:00:00

abstract：AIM:A new antibody reacted with an epitope in Lp(a) that has undergone oxidation treatment, but is not present in native Lp(a), was developed. Thus, we determined serum oxidized Lp(a) concentration in healthy volunteers, and coronary artery disease (CAD), diabetes mellitus (DM), and hypertensive patients. METHODS:We m...

journal_title：Journal of atherosclerosis and thrombosis

authors： Morishita R,Ishii J,Kusumi Y,Yamada S,Komai N,Ohishi M,Nomura M,Hishida H,Niihashi M,Mitsumata M

更新日期：2009-08-01 00:00:00

abstract：:The proliferation of vascular smooth muscle cells (VSMCs) can contribute to a variety of pathological states, including atherosclerosis and post-angioplasty restenosis. The p21(WAF1) cyclin-dependent kinase inhibitor regulates cell-cycle progression, senescence, and differentiation in injured blood vessels. Histone de...

journal_title：Journal of atherosclerosis and thrombosis

authors： Okamoto H,Fujioka Y,Takahashi A,Takahashi T,Taniguchi T,Ishikawa Y,Yokoyama M

更新日期：2006-08-01 00:00:00

abstract：AIM:To evaluate the effect of statin therapy on the decrease of common carotid artery intima-media thickness (CCA-IMT) compared to placebo or usual care. METHODS:A systematic search of electronic databases (MEDLINE, EMBASE, and Cochrane Center Register) up to December 2011 was performed. Two reviewers independently de...

journal_title：Journal of atherosclerosis and thrombosis

authors： Huang Y,Li W,Dong L,Li R,Wu Y

更新日期：2013-01-01 00:00:00

abstract：AIM:Recent evidence suggests that small dense low-density lipoprotein (sd-LDL) particles are more atherogenic than large-LDL in spite of their lower cholesterol content. This study aimed to determine whether sd-LDL-cholesterol (sd-LDL-C) is superior to LDL-C as a biomarker of coronary heart disease (CHD). METHODS:LDL ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Koba S,Yokota Y,Hirano T,Ito Y,Ban Y,Tsunoda F,Sato T,Shoji M,Suzuki H,Geshi E,Kobayashi Y,Katagiri T

更新日期：2008-10-01 00:00:00

abstract：:Cell degeneration and collagenosis are the main features in atherosclerotic plaque. We examined the effects of human low density lipoprotein (LDL) on cultured rabbit aortic smooth muscle cells (SMCs). Copper oxidized LDL (LDL+Cu) injured the SMCs more than did native LDL. Cytotoxicity of oxidized LDL was prevented by ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Jimi S,Sakata N,Takebayashi S

更新日期：1994-01-01 00:00:00

abstract：AIM:The purpose of this study was to compare two homogeneous assays of low-density lipoprotein-cholesterol (LDL-C) with a modified beta quantification reference measurement for LDL-C (BQ-LDL), fractions of chylomicron (CM), very low-density lipoprotein (VLDL) and intermediate-density lipoprotein (IDL) by quantitative u...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yano M,Matsunaga A,Harada S,Zhang B,Kawachi E,Tadera M,Saku K

更新日期：2019-11-01 00:00:00

abstract：:Zetia (ezetimibe) is a selective cholesterol absorption inhibitor, which potently inhibits the absorption of biliary and dietary cholesterol from the small intestine without affecting the absorption of fat-soluble vitamins, triglycerides or bile acids. Ezetimibe reduces the small intestinal enterocyte uptake and absor...

journal_title：Journal of atherosclerosis and thrombosis

authors： Davis HR,Veltri EP

更新日期：2007-06-01 00:00:00

abstract：AIM:It has been reported that beta-blockers (BB) reduce cardiovascular events in patients with atherosclerotic disease. However, little is known about the efficacy of these drugs in patients with critical limb ischemia (CLI). We investigated whether beta-blocker therapy affects the clinical outcomes of CLI patients. M...

journal_title：Journal of atherosclerosis and thrombosis

authors： Soga Y,Iida O,Takahara M,Hirano K,Suzuki K,Kawasaki D

更新日期：2015-01-01 00:00:00

abstract：AIM:The purpose of this study is to investigate the impact of arterial stiffness assessed using Cardio-ankle Vascular Index (CAVI) on long-term outcome after acute coronary syndrome (ACS). METHODS:A total of 387 consecutive patients (324 males; age, 64±11 years) with ACS were enrolled. We examined CAVI and brachial-an...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kirigaya J,Iwahashi N,Tahakashi H,Minamimoto Y,Gohbara M,Abe T,Akiyama E,Okada K,Matsuzawa Y,Maejima N,Hibi K,Kosuge M,Ebina T,Tamura K,Kimura K

更新日期：2020-07-01 00:00:00

abstract：AIM:The INK4b-ARF-INK4a locus in the chromosome 9p21 region is known to play an important role in the development of atherosclerosis. The INK4/ARF transcript p16(INK4a) inhibits the activity of the cyclin-dependent kinases CDK4/CDK6 and arrests cell-cycle progression. CDK inhibitors also regulate G1/S phase progression...

journal_title：Journal of atherosclerosis and thrombosis

authors： Bayoglu B,Arslan C,Gode S,Kaya Dagistanli F,Arapi B,Burc Deser S,Dirican A,Cengiz M

更新日期：2014-01-01 00:00:00

abstract：AIM:All health insurers in Japan are mandated to provide Specific Health Checkups and Specific Health Guidance (SHG) focusing on metabolic syndrome (MetS) in middle-aged adults, beginning in 2008; intensive HG for individuals who have abdominal obesity and two or more additional MetS risk factors, and motivational HG f...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tsushita K,S Hosler A,Miura K,Ito Y,Fukuda T,Kitamura A,Tatara K

更新日期：2018-04-01 00:00:00

abstract：AIMS:Perilipin and adipophilin, PAT family proteins, play important roles in lipid metabolism. Although nonalcoholic fatty liver disease (NAFLD) is initiated by hepatocyte lipidation, little is known about the relationship between these proteins and hepatocellular injury. We investigated the expressions of perilipin an...

journal_title：Journal of atherosclerosis and thrombosis

authors： Fujii H,Ikura Y,Arimoto J,Sugioka K,Iezzoni JC,Park SH,Naruko T,Itabe H,Kawada N,Caldwell SH,Ueda M

更新日期：2009-01-01 00:00:00

abstract：:Recent findings suggest that the oxidative modification of low-density lipoproteins (LDL) and an increase in triglyceride-rich lipoprotein particles including chylomicron remnants contribute to the progression of atherosclerosis, as does the inflammatory response. We therefore examined whether and how these lipoprotei...

journal_title：Journal of atherosclerosis and thrombosis

authors： Okumura T,Fujioka Y,Morimoto S,Masai M,Sakoda T,Tsujino T,Kashiwamura S,Okamura H,Ohyanagi M

更新日期：2006-02-01 00:00:00

abstract：AIM:Increased levels of small dense low-density lipoproteins (sd-LDL) have been reported more atherogenic compared to total low-density lipoprotein (LDL); however, no definitive experiments using macrophages have examined this concept in vitro. METHOD AND RESULT:In this study, we isolated fractions of total LDL (densi...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tani M,Kawakami A,Mizuno Y,Imase R,Ito Y,Kondo K,Ishii H,Yoshida M

更新日期：2011-01-01 00:00:00

abstract：AIM:Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders associated with metabolic syndrome, and its prevalence has been on the rise. The pathogenesis of NAFLD has not yet been sufficiently elucidated due to the multifactorial nature of the disease, although the activation of macr...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yoshii D,Nakagawa T,Komohara Y,Kawaguchi H,Yamada S,Tanimoto A

更新日期：2020-10-02 00:00:00

abstract：AIM:Inherent mechanisms leading to vascular smooth muscle cells (VSMC) alterations in obesitylinked type 2 diabetes (T2D) situation remain to be clarified. This study evaluates the impact of supernatant of adipocytes extracted from mice fed high-fat-diets (HFD) on the proliferation and apoptosis of VSMC. METHODS:Adipo...

journal_title：Journal of atherosclerosis and thrombosis

authors： El Akoum S,Cloutier I,Tanguay JF

更新日期：2012-01-01 00:00:00