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Seasonal variation in critical limb ischemia requiring endovascular therapy: an analysis of a multicenter database of Japanese patients with critical limb ischemia undergoing endovascular therapy.

Abstract：

AIM:We investigated whether any seasonal variation is observed in the incidence, severity and prognosis of critical limb ischemia (CLI) requiring endovascular therapy. METHODS:We analyzed a multicenter database of 1,568 consecutive CLI cases undergoing primary endovascular therapy for infrainguinal lesions between July 2004 and June 2011. The monthly incidence was assessed according to the cumulative number of cases in each month, using a simple moving average. The data were fitted to a nonlinear regression model with a cosine function. The monthly proportion of cases in each Rutherford classification among the overall CLI population was assessed using a multinomial logistic regression model. The monthly risk of major amputation was evaluated using a Cox proportional hazard regression model. RESULTS:Significant seasonal variation was observed in the incidence of CLI (p＜0.01). It was higher in the period from winter to spring, with a peak in March, and lower in the period from summer to autumn, with a trough in September; the fold difference between the peak and trough was 2.2. The seasonal variation was more markedly observed in the cases with a more severe Rutherford class. The proportion of cases in each Rutherford class among the overall CLI population also exhibited significant seasonal variation (p＜0.01). In addition, the risk of major amputation demonstrated significant seasonal variation (p=0.03); however, the statistical significance was lost following adjustment for the Rutherford classification (p=0.10). CONCLUSIONS:Seasonal variation is observed in the incidence and severity of CLI. The seasonality of the limb prognosis is likely explained by that of the CLI severity.

journal_name

J Atheroscler Thromb

journal_title

Journal of atherosclerosis and thrombosis

authors

Takahara M,Iida O,Soga Y,Hirano K,Yamaoka T,Kawasaki D,Suzuki K,Suematsu N,Shintani Y,Miyashita Y,Kaneto H,Shimomura I

doi

10.5551/jat.18283

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

726-32

issue

eissn

1340-3478

issn

1880-3873

pii

DN/JST.JSTAGE/jat/18283

journal_volume

pub_type

杂志文章,多中心研究

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Seasonal variation in critical limb ischemia requiring endovascular therapy: an analysis of a multicenter database of Japanese patients with critical limb ischemia undergoing endovascular therapy.