Small LDL-cholesterol is superior to LDL-cholesterol for determining severe coronary atherosclerosis.


AIM:Recent evidence suggests that small dense low-density lipoprotein (sd-LDL) particles are more atherogenic than large-LDL in spite of their lower cholesterol content. This study aimed to determine whether sd-LDL-cholesterol (sd-LDL-C) is superior to LDL-C as a biomarker of coronary heart disease (CHD). METHODS:LDL particle size determined by gradient gel electrophoresis and sd-LDL-C concentrations quantified by heparin-magnesium precipitation were compared between 482 stable CHD patients and 389 non-diabetic subjects without CHD who were not receiving any lipid-lowering drugs. RESULTS:Both male and female CHD patients had significantly smaller LDL particles and lower large-LDL-C concentrations (estimated by subtracting the sd-LDL-C concentration from the LDL-C concentration), and significantly higher sd-LDL-C concentrations than the control subjects. LDL-C concentrations were modestly higher and sd-LDL-C concentrations were significantly higher in 258 patients with angiographically documented severe CHD than in the patients with mild CHD irrespective of treatment by LDL-lowering drugs and history of myocardial infarction and/or coronary revascularization. Large-LDL-C concentrations, in contrast, were similar between the two groups. Multivariate logistic regression analysis revealed that sd-LDL-C levels were significantly associated with severe CHD independently of LDL-C. CONCLUSION:sd-LDL-C levels are more powerful than LDL-C levels for the determination of severe stable CHD.


J Atheroscler Thromb


Koba S,Yokota Y,Hirano T,Ito Y,Ban Y,Tsunoda F,Sato T,Shoji M,Suzuki H,Geshi E,Kobayashi Y,Katagiri T




Has Abstract


2008-10-01 00:00:00














  • Effects of an HMG-CoA reductase inhibitor, pravastatin, and bile sequestering resin, cholestyramine, on plasma plant sterol levels in hypercholesterolemic subjects.

    abstract::To study exogenous sterol metabolism during the suppression or stimulation of cholesterol biosynthesis induced by treatments for hyperlipidemia, we determined plasma plant sterol concentrations before and after administration of an HMG-CoA reductase inhibitor, pravastatin, and compared these with changes in these plas...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Hidaka H,Kojima H,Kawabata T,Nakamura T,Konaka K,Kashiwagi A,Kikkawa R,Shigeta Y

    更新日期:1995-01-01 00:00:00

  • The matrix metalloproteinase 2-1575 gene polymorphism is associated with the risk of developing myocardial infarction in Mexican patients.

    abstract:AIM:Was to evaluate the role of seven matrix metalloproteinase (MMP) polymorphisms in the genetic susceptibility to develop myocardial infarction in Mexican individuals. METHODS:Seven polymorphisms in the MMP genes were genotyped by 5' exonuclease TaqMan genotyping assays in 300 patients with myocardial infarction and...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Pérez-Hernández N,Vargas-Alarcón G,Martínez-Rodríguez N,Martínez-Ríos MA,Peña-Duque MA,Peña-Díaz Ade L,Valente-Acosta B,Posadas-Romero C,Medina A,Rodríguez-Pérez JM

    更新日期:2012-01-01 00:00:00

  • Adipokines and aging.

    abstract::Dysregulation of adipose tissue-derived bioactive molecules, termed adipokines, is recognized as common ground for insulin resistance and metabolic syndrome associated with obesity. However, adipokine dysregulation is paradoxically associated with lipodystrophy and lipoatrophy with aging. In familial partial lipodystr...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,评审


    authors: Arai Y,Takayama M,Abe Y,Hirose N

    更新日期:2011-01-01 00:00:00

  • Regional arterial stiffness associated with ischemic heart disease in type 2 diabetes mellitus.

    abstract::Arterial stiffness is increased in type 2 diabetes mellitus, and diabetes preferentially affects arterial stiffness of the central (elastic, capacitive) over peripheral (muscular, conduit) arteries. We hypothesized that arterial stiffness of the central artery may be more closely associated with ischemic heart disease...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Hatsuda S,Shoji T,Shinohara K,Kimoto E,Mori K,Fukumoto S,Koyama H,Emoto M,Nishizawa Y

    更新日期:2006-04-01 00:00:00

  • In addition to insulin resistance and obesity, brachial-ankle pulse wave velocity is strongly associated with metabolic syndrome in Chinese--a population-based study (Taichung Community Health Study, TCHS).

    abstract:AIM:To investigate the association between arterial stiffness (present with brachial-ankle pulse wave velocity (baPWV)) and metabolic syndrome (MetS) in a population-based study of middle-aged Chinese. METHODS:MetS was defined using the AHA/NHLBI criteria. A total of 1,018 subjects aged 40 years and over were recruite...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Lin WY,Lai MM,Li CI,Lin CC,Li TC,Chen CC,Lin T,Liu CS

    更新日期:2009-04-01 00:00:00

  • The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism.

    abstract::Although abdominal obesity or visceral obesity is considered to be one of the components of metabolic syndrome and to have an important role in a cluster of cardiovascular risks, there is no consensus about the definition and diagnostic criteria for this syndrome, probably because there is considerable disagreement ab...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,评审


    authors: Matsuzawa Y,Funahashi T,Nakamura T

    更新日期:2011-01-01 00:00:00

  • Markedly induced expression of LR11 in atherosclerosis.

    abstract::Receptors belonging to the low density lipoprotein receptor (LDLR) superfamily play important biological roles in addition to mediating the lipoprotein metabolism. The recent discovery of a novel mosaic LDLR family member by us (Yamazaki H, Bujo H, Kusunoki J, Seimiya K, Kanaki T, Morisaki N, Schneider WJ, and Saito Y...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Bujo H,Saito Y

    更新日期:2000-01-01 00:00:00

  • Association between the epicardial adipose tissue thickness and the presence of multivessel disease in patients with acute myocardial infarction.

    abstract:AIM:Epicardial adipose tissue (EAT) is implicated in the development of coronary atherosclerosis.We sought to investigate the association between the EAT thickness and presence of multivessel disease (MV) in patients with acute myocardial infarction (AMI). METHODS:We enrolled 45 consecutive patients with AMI who under...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Fukamachi D,Higuchi Y,Hiro T,Takayama T,Kanai T,Sudo M,Nishida T,Iida K,Saito S,Hirayama A

    更新日期:2015-01-01 00:00:00

  • Progression of Carotid Atherosclerosis in Two Japanese Populations with Different Lifestyles.

    abstract:AIM:We have conducted medical surveys on two Japanese populations (Japanese Americans living in the US and native Japanese living in Japan) to investigate the impact of westernization of lifestyles on diseases in Japanese people. A 1998 survey revealed that the progression of carotid intima-media wall thickness (IMT) w...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Kubota M,Yoneda M,Watanabe H,Egusa G

    更新日期:2017-10-01 00:00:00

  • Oxysterol-induced apoptosis of vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitor, pravastatin.

    abstract::We investigated the mechanism by which 7-ketocholesterol damages vascular smooth muscle cells and the protective effect of the hydroxymethyl glutary CoA reductase inhibitor, pravastatin on it. When 7-ketocholesterol (50 micromol/L) was added to cultured human vascular smooth muscle cells, the extent of cell detachment...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Miyashita Y,Ozaki H,Koide N,Otsuka M,Oyama T,Itoh Y,Mastuzaka T,Shirai K

    更新日期:2002-01-01 00:00:00

  • Urinary Stones and Risk of Coronary Heart Disease and Stroke: the Japan Public Health Center-Based Prospective Study.

    abstract:AIM:Evidence is lacking about whether urinary stones are associated with the subsequent risk of cardiovascular diseases. Herein, we investigated the association between history of urinary stones and the risk of coronary heart disease (CHD) and stroke among middle-aged Japanese. METHODS:This cohort study included 89,03...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Arafa A,Eshak ES,Iso H,Shirai K,Muraki I,Sawada N,Tsugane S,JPHC Study Group.

    更新日期:2020-11-01 00:00:00

  • Impact of Cardio-Ankle Vascular Index on Long-Term Outcome in Patients with Acute Coronary Syndrome.

    abstract:AIM:The purpose of this study is to investigate the impact of arterial stiffness assessed using Cardio-ankle Vascular Index (CAVI) on long-term outcome after acute coronary syndrome (ACS). METHODS:A total of 387 consecutive patients (324 males; age, 64±11 years) with ACS were enrolled. We examined CAVI and brachial-an...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Kirigaya J,Iwahashi N,Tahakashi H,Minamimoto Y,Gohbara M,Abe T,Akiyama E,Okada K,Matsuzawa Y,Maejima N,Hibi K,Kosuge M,Ebina T,Tamura K,Kimura K

    更新日期:2020-07-01 00:00:00

  • Relationship between Circulating Inflammatory Monocytes and Cardiovascular Disease Measures of Carotid Intimal Thickness.

    abstract:AIMS:Cardiovascular disease (CVD) remains the leading cause of death worldwide despite improvements in the treatment of atherosclerosis, an inflammatory disease and major underlying cause of CVD. Monocytes, an innate immune cell type, are linked to CVD progression; however, given their heterogeneity, the association be...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: SahBandar IN,Ndhlovu LC,Saiki K,Kohorn LB,Peterson MM,D'Antoni ML,Shiramizu B,Shikuma CM,Chow DC

    更新日期:2020-05-01 00:00:00

  • Relationship between Metabolic Syndrome Components and Periodontal Disease in a Japanese General Population: the Suita Study.

    abstract:AIM:A positive association between metabolic syndrome (MetS) and periodontal status has recently been noted. However, no study has evaluated the relationship by sex and in a general urban population using the uniform definition proposed in the 2009 Joint Interim Statement. The aim of this study was to clarify the relat...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Kikui M,Kokubo Y,Ono T,Kida M,Kosaka T,Yamamoto M,Watanabe M,Maeda Y,Miyamoto Y

    更新日期:2017-05-01 00:00:00

  • Hyperlipidemia and hemostatic system.

    abstract::The plasma levels of blood coagulation and fibrinolytic factors and the serum levels of lipids were measured in 62 subjects (22 normolipidemia and 40 hyperlipidemia) to investigate whether hyperlipidemia may affect the hemostatic system. Prothrombin, factors VII, IX and X were elevated in hyperlipidemic patients. The ...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Morishita E,Jokaji H,Matsuda T

    更新日期:1995-01-01 00:00:00

  • The potential role of macrophage migration inhibitory factor on the migration of vascular smooth muscle cells.

    abstract:AIM:Macrophage migration inhibitory factor (MIF) is known as a pro-inflammatory cytokine that regulates a broad spectrum of inflammatory reactions. MIF is expressed in vascular smooth muscle cells (VSMCs), and inhibition of the progression of atherosclerosis was observed in MIF-deficient atherosclerotic mice. However, ...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Okamoto T,Atsumi T,Shimizu C,Yoshioka N,Koike T

    更新日期:2008-02-01 00:00:00

  • Weight Change and Mortality from Cardiovascular Diseases: The Japan Collaborative Cohort Study.

    abstract:AIM:The aim of this study was to assess the association between weight change and mortality due to cardiovascular diseases (CVDs) in a Japanese population. METHODS:We used the data of a population-based prospective cohort study that was conducted from 1988 to 1990 in 45 areas throughout Japan. Among a total of 69,681 ...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Okada C,Kubota Y,Eshak ES,Cui R,Tamakoshi A,Iso H,and the JACC Study Group.

    更新日期:2021-01-01 00:00:00

  • Assessing Impact of High-Dose Pitavastatin on Carotid Artery Elasticity with Speckle-Tracking Strain Imaging.

    abstract:AIM:Speckle-tracking imaging has been introduced for the precise assessment of vessel mechanics. However, there are no data on the role of this imaging tool in assessing the changes in vasculature with statin therapy, which is known to enhance vascular elasticity. METHODS:This study was a prospective study including 4...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Hae Kim C,Wang S,Park JB,Jung KH,E Yoon Y,Lee SP,Kim HK,Kim YJ,Cho GY,Sohn DW

    更新日期:2018-11-01 00:00:00

  • The asymmetric dimethylarginine level is associated with the predicted stroke risk in Japanese women.

    abstract:AIM:Asymmetric dimethylarginine(ADMA) has recently been investigated as a risk marker for cardio- and cerebrovascular diseases. However, it is not currently known whether the ADMA levels are related to the risk of stroke in Japanese women. METHODS:We examined 192 Japanese women(mean age, 55±9 years, range, 40-80 years...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Muraga K,Nishiyama Y,Otsuka T,Ueda M,Abe A,Katayama Y

    更新日期:2014-01-01 00:00:00

  • Thyroid Hormone and Vascular Remodeling.

    abstract::Both hyperthyroidism and hypothyroidism affect the cardiovascular system. Hypothyroidism is known to be associated with enhanced atherosclerosis and ischemic heart diseases. The accelerated atherosclerosis in the hypothyroid state has been traditionally ascribed to atherogenic lipid profile, diastolic hypertension, an...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,评审


    authors: Ichiki T

    更新日期:2016-01-01 00:00:00

  • Clinical impact of the leptin to soluble leptin receptor ratio on subclinical carotid atherosclerosis in patients with type 2 diabetes.

    abstract:AIM:The adipocyte-derived hormone leptin plays a key role in the regulation of food intake and energy expenditure. Recent studies have suggested that leptin is also involved in the pathogenesis of obesity-associated atherosclerosis and cardiovascular disease. In this study, we investigated the associations of leptin an...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Yamazaki Y,Emoto M,Morioka T,Kawano N,Lee E,Urata H,Tsuchikura S,Motoyama K,Mori K,Fukumoto S,Shoji T,Nishizawa Y,Inaba M

    更新日期:2013-01-01 00:00:00

  • Effect of sulfonylurea agents on reverse cholesterol transport in vitro and vivo.

    abstract:AIM:Reverse cholesterol transport (RCT) is a critical mechanism for the anti-atherogenic property of HDL. The inhibitory effect of the sulfonylurea agent (SUA) glibenclamide on ATP binding-cassette transporter (ABC) A1 may decrease HDL function but it remains unclear whether it attenuates RCT in vivo. We therefore inve...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Terao Y,Ayaori M,Ogura M,Yakushiji E,Uto-Kondo H,Hisada T,Ozasa H,Takiguchi S,Nakaya K,Sasaki M,Komatsu T,Iizuka M,Horii S,Mochizuki S,Yoshimura M,Ikewaki K

    更新日期:2011-01-01 00:00:00

  • Endothelial lipase mediates HDL levels in normal and hyperlipidemic rabbits.

    abstract:AIM:Existing evidence suggests that endothelial lipase (EL) plays an important role in high-densitylipoprotein (HDL) metabolism. Because rabbits are a useful animal model for the study of human lipid metabolism and atherosclerosis, we characterized rabbit EL (rEL) expression and investigated its relationship with plasm...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Zhang J,Yu Y,Nakamura K,Koike T,Waqar AB,Zhang X,Liu E,Nishijima K,Kitajima S,Shiomi M,Qi Z,Yu J,Graham MJ,Crooke RM,Ishida T,Hirata K,Hurt-Camejo E,Chen YE,Fan J

    更新日期:2012-01-01 00:00:00

  • One-Year Clinical Outcomes following Implantation of InnovaTM Self-Expanding Nitinol Stents in Patients with Peripheral Artery Diseases Presenting Femoropopliteal Artery Lesions.

    abstract:AIM:Although the InnovaTM self-expanding nitinol stent (Boston Scientific, Marlborough, MA) exhibits acceptable performance in long-term safety and efficacy when used for the treatment of femoropopliteal (FP) lesions, clinical outcomes following its implantation have not been systematically studied in real-world settin...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,多中心研究


    authors: Tsujimura T,Takahara M,Iida O,Hiramori S,Hayakawa N,Karashima E,Miura T,Teramura M,Ichihashi K,Kojima T,Aihara H,Yamaoka T,Fujihara M,Tosaka A,Doijiri T,Mano T,Soga Y

    更新日期:2019-10-01 00:00:00

  • The History of the WHHL Rabbit, an Animal Model of Familial Hypercholesterolemia (II) - Contribution to the Development and Validation of the Therapeutics for Hypercholesterolemia and Atherosclerosis.

    abstract::A number of effective drugs have been developed through animal experiments, contributing to the health of many patients. In particular, the WHHL rabbit family (WHHL rabbits and its advanced strains (coronary atherosclerosis-prone WHHL-CA rabbits and myocardial infarction-prone WHHLMI rabbits) developed at Kobe Univers...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 历史文章,杂志文章


    authors: Shiomi M

    更新日期:2020-02-01 00:00:00

  • The association between low-density lipoprotein cholesterol goal attainment, physician and patient attitudes and perceptions, and healthcare policy.

    abstract:AIM:Withholding effective treatment is clinically prevalent. The CEntralized Pan-Asian survey on tHE Under-treatment of hypercholeSterolemia (CEPHEUS-PA) indicated suboptimal low-density lipoprotein cholesterol (LDL-C) goal attainment in Taiwan, which may be attributable to clinical inertia. We herein analyzed the Taiw...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Wang KL,Wu CH,Wang KF,Chang CC,Chen LC,Lu TM,Lin SJ,Chiang CE

    更新日期:2014-01-01 00:00:00

  • Associations between plasma C-reactive protein levels and the severities of coronary and aortic atherosclerosis.

    abstract:AIM:Limited correlations between C-reactive protein (CRP) and coronary artery disease (CAD) have been reported. Recently, MRI became a useful tool for non-invasively evaluating atherosclerotic plaques in thoracic and abdominal aortas. METHODS:To elucidate the associations between plasma CRP levels and the severities o...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Momiyama Y,Ohmori R,Fayad ZA,Kihara T,Tanaka N,Kato R,Taniguchi H,Nagata M,Nakamura H,Ohsuzu F

    更新日期:2010-05-01 00:00:00

  • HDL2/HDL3 Ratio Changes, Metabolic Syndrome Markers, and Other Factors in a Japanese Population.

    abstract:AIM AND METHODS:The high-density lipoprotein 2 cholesterol (HDL2-C) to HDL3-C ratio is associated with insulin resistance, high-molecular-weight adiponectin (HMW-Ad), and metabolic syndrome (MetS) components and is useful for evaluating MetS in Japanese individuals. We investigated potential associations between change...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Moriyama K,Takahashi E

    更新日期:2016-06-01 00:00:00

  • Current therapy for patients with sitosterolemia--effect of ezetimibe on plant sterol metabolism.

    abstract::Sitosterolemia is a rare, autosomal recessive inherited sterol storage disease associated with high tissue and serum plant sterol concentrations, caused by mutations in the adenosine triphosphate-bind-ing cassette (ABC) transporter ABCG5 or ABCG8 genes. Markedly increased serum concentration of plant sterols. such as ...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,评审


    authors: Tsubakio-Yamamoto K,Nishida M,Nakagawa-Toyama Y,Masuda D,Ohama T,Yamashita S

    更新日期:2010-09-30 00:00:00

  • Self-reported Sleep Duration and Subclinical Atherosclerosis in a General Population of Japanese Men.

    abstract:AIM:There are few data regarding associations between sleep duration and subclinical atherosclerosis in Japan. The aim of this study was to evaluate associations of self-reported sleep duration with calcification in the coronary arteries (CAC) and carotid intima media thickness (IMT) in Japanese men. METHODS:This was ...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,随机对照试验


    authors: Suzuki S,Arima H,Miyazaki S,Fujiyoshi A,Kadota A,Takashima N,Hisamatsu T,Kadowaki S,Zaid M,Torii S,Horie M,Murata K,Miura K,Ueshima H,SESSA Research Group.

    更新日期:2018-02-01 00:00:00