The potential role of macrophage migration inhibitory factor on the migration of vascular smooth muscle cells.

abstract：AIM:Up-regulation of soluble CD40 ligand (sCD40L) and of monocyte chemoattractant protein-1 (MCP-1) has been found in diabetes and in patients with acute cerebral ischemia. We asked whether (i) the two molecules are similarly upregulated among non-lacunar and lacunar diabetic strokes and (ii) sCD40L and/or MCP-1 predic...

journal_title：Journal of atherosclerosis and thrombosis

authors： Davì G,Tuttolomondo A,Santilli F,Basili S,Ferrante E,Di Raimondo D,Pinto A,Licata G

更新日期：2009-01-01 00:00:00

abstract：AIM:CCL22, mainly synthesized by monocyte-derived alternative (M2) macrophages, belongs to the CC family of chemokines and is involved in monocyte migration and recruitment. We have previously investigated CCL22 and histamine in atherosclerosis. Here, we investigated the hypothesis that CCL22 is involved in atheroscler...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kimura S,Noguchi H,Nanbu U,Wang KY,Sasaguri Y,Nakayama T

更新日期：2018-12-01 00:00:00

abstract：:We tried to investigate whether accumulation of visceral fat assessed by a simple but widely used ultrasonography was associated with common carotid atherosclerosis in women. The subjects were consecutively admitted in-patients whose body mass index was more than 22 kg/m2. Those with cardiorenal or nutritional disorde...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kawamoto R,Kajiwara T,Oka Y,Takagi Y

更新日期：2002-01-01 00:00:00

abstract：AIM:Hypercholesterolemic patients with inflammation are at high risk for cardiovascular events. Statins exert anti-inflammatory action independent of their cholesterol-lowering action. This study sought to clarify whether statin therapy reduces inflammatory markers in hypercholesterolemic patients and to determine fact...

journal_title：Journal of atherosclerosis and thrombosis

authors： Horiuchi Y,Hirayama S,Soda S,Seino U,Kon M,Ueno T,Idei M,Hanyu O,Tsuda T,Ohmura H,Miida T

更新日期：2010-07-30 00:00:00

abstract：AIMS:Statins not only reduce low-density lipoprotein (LDL) cholesterol, but also prevent the progression of kidney dysfunction. Ezetimibe, a cholesterol-absorption inhibitor, also lowers LDL cholesterol levels when added to statins; however, the effect of add-on ezetimibe on kidney function has had conflicting results....

journal_title：Journal of atherosclerosis and thrombosis

authors： Kinouchi K,Ichihara A,Bokuda K,Morimoto S,Itoh H

更新日期：2013-01-01 00:00:00

abstract：AIMS:Patients with chronic kidney disease (CKD) have a higher burden of cardiovascular morbidity and mortality than the general population. Endothelial dysfunction has been suggested to play a role in both glomerular filtration rate loss and cardiovascular damage. Thus, the present study aimed to evaluate the relations...

journal_title：Journal of atherosclerosis and thrombosis

authors： Li Y,Cui R,Liu K,Eshak ES,Cui M,Dong J,Imano H,Muraki I,Kiyama M,Kitamura A,Okada T,Yamagishi K,Umesawa M,Ohira T,Iso H,CIRCS investigators.

更新日期：2020-09-02 00:00:00

abstract：AIM:Patients with acute infectious diseases are at an increased risk of venous thromboembolism (VTE). Clinicians should be aware of the VTE risk in patients with COVID-19, many of whom present with severe coagulation disorders. METHOD:We used an online platform to conduct a cross-sectional questionnaire survey among d...

journal_title：Journal of atherosclerosis and thrombosis

authors： Zhang Z,Xi L,Zhang S,Zhang Y,Pang W,Wang Y,Li C,Zhai Z,Wang C

更新日期：2020-10-01 00:00:00

abstract：:Our purpose was to determine whether lipid peroxides are elevated in the plasma of patients with non-insulin dependent diabetes with multiple lacunar infarcts as detected by magnetic resonance imaging (MRI), and to confirm whether peroxide levels correlate with glycemic controls and blood lipid levels. The level of li...

journal_title：Journal of atherosclerosis and thrombosis

authors： Fujiwara Y,Nishihara H,Nakakoshi T,Hasegawa T,Tagami S,Kawakami Y

更新日期：1997-01-01 00:00:00

abstract：AIM:Was to evaluate the role of seven matrix metalloproteinase (MMP) polymorphisms in the genetic susceptibility to develop myocardial infarction in Mexican individuals. METHODS:Seven polymorphisms in the MMP genes were genotyped by 5' exonuclease TaqMan genotyping assays in 300 patients with myocardial infarction and...

journal_title：Journal of atherosclerosis and thrombosis

authors： Pérez-Hernández N,Vargas-Alarcón G,Martínez-Rodríguez N,Martínez-Ríos MA,Peña-Duque MA,Peña-Díaz Ade L,Valente-Acosta B,Posadas-Romero C,Medina A,Rodríguez-Pérez JM

更新日期：2012-01-01 00:00:00

abstract：AIM:Sarcopenic obesity (SO) is closely associated with cardiovascular disease (CVD) in elderly women. Increases in body fat and decreases in muscle mass are closely associated with increased carotid intima-media thickness (CIMT). The aim of this study was to examine the influence of a 24-week aerobic and resistance tra...

journal_title：Journal of atherosclerosis and thrombosis

authors： Park J,Kwon Y,Park H

更新日期：2017-11-01 00:00:00

abstract：AIM:Familial hypercholesterolemia (FH) is the most commonly encountered genetic condition that predisposes individuals to severe autosomal dominant lipid metabolism dysfunction. Although more than 75% of the European population has been scrutinized for FH-causing mutations, the genetic diagnosis proportion among Chines...

journal_title：Journal of atherosclerosis and thrombosis

authors： Wang H,Yang H,Liu Z,Cui K,Zhang Y,Zhang Y,Zhao K,Yin K,Li W,Zhou Z

更新日期：2020-12-01 00:00:00

abstract：AIM:Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders associated with metabolic syndrome, and its prevalence has been on the rise. The pathogenesis of NAFLD has not yet been sufficiently elucidated due to the multifactorial nature of the disease, although the activation of macr...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yoshii D,Nakagawa T,Komohara Y,Kawaguchi H,Yamada S,Tanimoto A

更新日期：2020-10-02 00:00:00

abstract：AIM:The clinical relevance of the suggested pleiotropic effects of hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) is controversial. Aggressive statins effectively reduce lipid levels, but whether their other effects are more powerful than those of regular statins is unknown. METHODS:We enrolled 32 pat...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hoshiga M,Arishiro K,Nakakoji T,Miyazaki N,Negoro N,Okabe T,Kohbayashi E,Ishihara T,Hanafusa T

更新日期：2010-07-30 00:00:00

abstract：AIM:Resistin is an adipocytokine that may link inflammation and atherosclerosis.We studied the associations of resistin levels with cardiovascular events and restenosis. METHODS:We measured pre-procedural serum resistin levels in 140 patients with coronary artery disease undergoing elective percutaneous coronary inter...

journal_title：Journal of atherosclerosis and thrombosis

authors： Momiyama Y,Ohmori R,Uto-Kondo H,Tanaka N,Kato R,Taniguchi H,Arakawa K,Nakamura H,Ohsuzu F

更新日期：2011-01-01 00:00:00

abstract：:A number of effective drugs have been developed through animal experiments, contributing to the health of many patients. In particular, the WHHL rabbit family (WHHL rabbits and its advanced strains (coronary atherosclerosis-prone WHHL-CA rabbits and myocardial infarction-prone WHHLMI rabbits) developed at Kobe Univers...

journal_title：Journal of atherosclerosis and thrombosis

authors： Shiomi M

更新日期：2020-02-01 00:00:00

abstract：AIM:To investigatethe association of plasma epoxyeicosatrienoic acids (EETs) with early neurologic deterioration (END), and whether EETs are mediated by EPHX2 variants in patients with minor ischemic stroke (MIS). METHOD:This was a prospective, multi-center observational study in patients with acute MIS in the Chinese...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yi X,Lin J,Li J,Zhou Q,Han Z

更新日期：2017-12-01 00:00:00

abstract：AIM:The ankle-brachial index(ABI) is an easy-to-use, non-invasive and reliable diagnostic tool for assessing peripheral arterial occlusive disease(PAOD). The CHADS2(congestive heart failure, hypertension, age ≧75 years, diabetes, prior stroke) score is a simple and popular clinical parameter that is used to assess the ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hsu PC,Lin TH,Lee WH,Chu CY,Chiu CA,Lee HH,Su HM,Voon WC,Lai WT,Sheu SH

更新日期：2014-01-01 00:00:00

abstract：AIM:A novel device has been developed for measuring the cardio-ankle vascular index (CAVI) as an indicator of arterial stiffness. In this study, we evaluated the effect of pitavastatin on CAVI in type 2 diabetic patients. METHODS:Forty-five type 2 diabetes mellitus patients with low-density lipoprotein cholesterolemia...

journal_title：Journal of atherosclerosis and thrombosis

authors： Miyashita Y,Endo K,Saiki A,Ban N,Yamaguchi T,Kawana H,Nagayama D,Ohira M,Oyama T,Shirai K

更新日期：2009-10-01 00:00:00

abstract：:Blood lipid levels are highly heritable and modifiable risk factors for coronary artery disease (CAD), and are the leading cause of death worldwide. These facts have motivated human genetic association studies that have the substantial potential to define the risk factors that are causal and to identify pathways and t...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tada H,Kawashiri MA,Konno T,Yamagishi M,Hayashi K

更新日期：2016-01-01 00:00:00

abstract：AIMS:Cardiovascular disease (CVD) remains the leading cause of death worldwide despite improvements in the treatment of atherosclerosis, an inflammatory disease and major underlying cause of CVD. Monocytes, an innate immune cell type, are linked to CVD progression; however, given their heterogeneity, the association be...

journal_title：Journal of atherosclerosis and thrombosis

authors： SahBandar IN,Ndhlovu LC,Saiki K,Kohorn LB,Peterson MM,D'Antoni ML,Shiramizu B,Shikuma CM,Chow DC

更新日期：2020-05-01 00:00:00

abstract：:Although abdominal obesity or visceral obesity is considered to be one of the components of metabolic syndrome and to have an important role in a cluster of cardiovascular risks, there is no consensus about the definition and diagnostic criteria for this syndrome, probably because there is considerable disagreement ab...

journal_title：Journal of atherosclerosis and thrombosis

authors： Matsuzawa Y,Funahashi T,Nakamura T

更新日期：2011-01-01 00:00:00

abstract：AIM:To assess the long-term effects of intracoronary stem cell (SC) infusion following acute myocardial infarction (AMI) on the local atherosclerotic process at the site of infusion after four years of follow-up. METHODS:We evaluated 18 post-AMI patients. Group 1 consisted of nine patients given an intracoronary injec...

journal_title：Journal of atherosclerosis and thrombosis

authors： Benedek I,Bucur O,Benedek T

更新日期：2014-01-01 00:00:00

abstract：:Receptors belonging to the low density lipoprotein receptor (LDLR) superfamily play important biological roles in addition to mediating the lipoprotein metabolism. The recent discovery of a novel mosaic LDLR family member by us (Yamazaki H, Bujo H, Kusunoki J, Seimiya K, Kanaki T, Morisaki N, Schneider WJ, and Saito Y...

journal_title：Journal of atherosclerosis and thrombosis

authors： Bujo H,Saito Y

更新日期：2000-01-01 00:00:00

abstract：AIM:In Japan, heart disease and cerebral ischemic disease are major causes of death. A decrease in the level of low-density lipoprotein cholesterol (LDL-C) through intensive treatment with statins positively correlates with a reduction in the volume of plaques in patients with cardiovascular disease. The METEOR trial, ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kurabayashi M,Sakuma I,Kawamori R,Daida H,Yamazaki T,Yoshida M,Hata M,Masuda I,Kaku K,Yokoi H,Kishimoto J,Nohara R

更新日期：2010-04-30 00:00:00

abstract：AIM:We evaluated the impact of adherence to preferable behavior on serum lipid control assessed by a self-reported questionnaire in high-risk patients taking pravastatin for primary prevention of coronary artery disease. METHODS:High-risk patients taking pravastatin were followed for 2 years. Questionnaire surveys com...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kitagawa Y,Teramoto T,Daida H,APPROACH-J Study group.

更新日期：2012-01-01 00:00:00

abstract：:Inflammation and oxidative stress play key roles in atherosclerotic plaque instability, and plaque rupture/erosion and subsequent thrombus formation constitute the principal mechanisms of total vessel occlusion and acute ST-elevation myocardial infarction (STEMI). Plaque disruption triggers the formation of initial pl...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yunoki K,Naruko T,Sugioka K,Inaba M,Itoh A,Haze K,Yoshiyama M,Ueda M

更新日期：2013-01-01 00:00:00

abstract：AIM:The Framingham risk score (FRS) is one of the standard tools used to predict the incidence of coronary heart disease (CHD). No previous study has investigated its efficacy for a Japanese population cohort. The purpose of this study was to develop new coronary prediction algorithms for the Japanese population in the...

journal_title：Journal of atherosclerosis and thrombosis

authors： Nishimura K,Okamura T,Watanabe M,Nakai M,Takegami M,Higashiyama A,Kokubo Y,Okayama A,Miyamoto Y

更新日期：2014-01-01 00:00:00

abstract：:Oxidative stress induced by reactive oxygen species (ROS) plays an important role in atherogenesis, and the redox state is determined by the balance between antioxidants and the ROS generating system. To defend against enhanced ROS, mammalian cells have a complex network of antioxidant enzymes such as superoxide dismu...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kobayashi S,Inoue N,Azumi H,Seno T,Hirata K,Kawashima S,Hayashi Y,Itoh H,Yokozaki H,Yokoyama M

更新日期：2002-01-01 00:00:00

abstract：:Elevated resting heart rate (HR) is associated with hypertension in addition to or similar to increased incidence of cardiovascular morbidity and mortality. Subjects with high HR exhibit the characteristic features of insulin resistance syndrome. Sympathetic overactivity underlies this clinical condition. However, the...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hasegawa T,Watase H

更新日期：2003-01-01 00:00:00

abstract：AIM:Coronary artery stenosis (CAS) ≥ 50% frequently coexists in patients with acute ischemic cerebrovascular disease (AICVD), which portends unfavorable outcomes. We sought to examine whether patients with AICVD with CAS had more severe and more diffused cervicocephalic atherosclerosis (CA). METHODS:Patients with AICV...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kong Q,Ma X,Wang C,Feng W,Ovbiagele B,Zhang Y,Du X

更新日期：2019-09-01 00:00:00