Cardiorespiratory Fitness is a Strong Predictor of the Cardio-ankle Vascular Index in Hypertensive Middle-aged and Elderly Japanese Men.

abstract：AIM:Asymmetric dimethylarginine(ADMA) has recently been investigated as a risk marker for cardio- and cerebrovascular diseases. However, it is not currently known whether the ADMA levels are related to the risk of stroke in Japanese women. METHODS:We examined 192 Japanese women(mean age, 55±9 years, range, 40-80 years...

journal_title：Journal of atherosclerosis and thrombosis

authors： Muraga K,Nishiyama Y,Otsuka T,Ueda M,Abe A,Katayama Y

更新日期：2014-01-01 00:00:00

abstract：:The aim was to give on overview of the profile of cardiovascular disease, vascular pathology and the relationships between lifestyle and cardiovascular disease in Japanese. Compared with the United States and Europe, the higher mortality from stroke and lower mortality from coronary heart disease constitute a unique c...

journal_title：Journal of atherosclerosis and thrombosis

authors： Iso H

更新日期：2011-01-01 00:00:00

abstract：:Recent findings suggest that the oxidative modification of low-density lipoproteins (LDL) and an increase in triglyceride-rich lipoprotein particles including chylomicron remnants contribute to the progression of atherosclerosis, as does the inflammatory response. We therefore examined whether and how these lipoprotei...

journal_title：Journal of atherosclerosis and thrombosis

authors： Okumura T,Fujioka Y,Morimoto S,Masai M,Sakoda T,Tsujino T,Kashiwamura S,Okamura H,Ohyanagi M

更新日期：2006-02-01 00:00:00

abstract：AIM:The arterial pressure-volume index (API) and arterial velocity-pulse index (AVI) are novel measurement indices of arterial stiffness. This study was performed to examine the screening validity of the API and AVI for preclinical atherosclerosis in Japanese community-dwelling adults. METHODS:We conducted a cross-sec...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yamanashi H,Koyamatsu J,Nagayoshi M,Shimizu Y,Kawashiri SY,Kondo H,Fukui S,Tamai M,Maeda T

更新日期：2018-09-01 00:00:00

abstract：AIMS:Renal dysfunction is a major public health problem, but there have been few investigations of the relationship between serum high molecular weight (HMW) adiponectin and renal function in Japanese community-dwelling adults. METHODS:We randomly recruited a sample of 1,849 adult Japanese (793 men aged 60 ± 14 (mean ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kawamoto R,Tabara Y,Kohara K,Miki T,Abe M,Kusunoki T,Katoh T,Ohtsuka N

更新日期：2010-11-27 00:00:00

abstract：AIM:Coronary artery stenosis (CAS) ≥ 50% frequently coexists in patients with acute ischemic cerebrovascular disease (AICVD), which portends unfavorable outcomes. We sought to examine whether patients with AICVD with CAS had more severe and more diffused cervicocephalic atherosclerosis (CA). METHODS:Patients with AICV...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kong Q,Ma X,Wang C,Feng W,Ovbiagele B,Zhang Y,Du X

更新日期：2019-09-01 00:00:00

abstract：AIM:The purpose of this study was to evaluate the efficacy and safety of LIVALO tablets (pitavastatin) in Japanese male children with heterozygous familial hypercholesterolemia (FH). METHODS:A multicenter, randomized, double-blind, parallel study was conducted in 14 male children 10-15 years of age with heterozygous F...

journal_title：Journal of atherosclerosis and thrombosis

authors： Harada-Shiba M,Arisaka O,Ohtake A,Okada T,Suganami H,NK-104-PH 01 study registration group.

更新日期：2016-01-01 00:00:00

abstract：AIM:Epicardial adipose tissue (EAT) has been suggested as a contributing factor for coronary atherosclerosis based on the previous cross-sectional studies and pathophysiologic background. However, a causal relationship between EAT and the development of non-calcified coronary plaque (NCP) has not been investigated. ME...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hwang IC,Park HE,Choi SY

更新日期：2017-03-01 00:00:00

abstract：AIM:We hypothesized that excessive suppression of platelet function due to antiplatelet therapy can increase the incidence of bleeding complications. The aim of the present study was to find whether we could predict bleeding events by measuring platelet function. METHODS:We enrolled 743 subjects whose platelet functio...

journal_title：Journal of atherosclerosis and thrombosis

authors： Sairaku A,Nakano Y,Eno S,Hondo T,Matsuda K,Kisaka T,Kihara Y

更新日期：2011-01-01 00:00:00

abstract：AIM:Soluble cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1, E-selectin, and P-selectin, have been suggested to be associated with cardiovascular disease (CVD) risk; however, the nature and magnitude of the association between VCAM-1 and CVD risk is uncerta...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kunutsor SK,Bakker SJL,Dullaart RPF

更新日期：2017-08-01 00:00:00

abstract：:Although the human liver comprises approximately 2.8% of the body weight, it plays a central role in the control of energy metabolism. While the biochemistry of energy substrates such as glucose, fatty acids, and ketone bodies in the liver is well understood, many aspects of the overall control system for hepatic meta...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yahagi N

更新日期：2017-01-01 00:00:00

abstract：AIMS:Statins not only reduce low-density lipoprotein (LDL) cholesterol, but also prevent the progression of kidney dysfunction. Ezetimibe, a cholesterol-absorption inhibitor, also lowers LDL cholesterol levels when added to statins; however, the effect of add-on ezetimibe on kidney function has had conflicting results....

journal_title：Journal of atherosclerosis and thrombosis

authors： Kinouchi K,Ichihara A,Bokuda K,Morimoto S,Itoh H

更新日期：2013-01-01 00:00:00

abstract：AIM:The association between urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), an oxidative stress marker, and the incidence of cardiovascular disease (CVD) has not been confirmed because no previous studies evaluated 24-hour 8-OHdG excretion levels in the general population. We aimed to confirm the association between 24-h...

journal_title：Journal of atherosclerosis and thrombosis

authors： Nagao M,Kobashi G,Umesawa M,Cui R,Yamagishi K,Imano H,Okada T,Kiyama M,Kitamura A,Sairenchi T,Haruyama Y,Ohira T,Iso H,CIRCS Investigators.

更新日期：2020-10-01 00:00:00

abstract：AIM:Associations between long-term exposure to particulate matter (PM) and increased cardiovascular mortality have been reported, but few studies have investigated the associated incidence of cardiovascular disease, and none involved men. METHODS:We used data on 78,057 participants (37,121 men, 40,936 women) to examin...

journal_title：Journal of atherosclerosis and thrombosis

authors： Nishiwaki Y,Michikawa T,Takebayashi T,Nitta H,Iso H,Inoue M,Tsugane S,Japan Public Health Center-based Prospective Study Group.

更新日期：2013-01-01 00:00:00

abstract：:A number of effective drugs have been developed through animal experiments, contributing to the health of many patients. In particular, the WHHL rabbit family (WHHL rabbits and its advanced strains (coronary atherosclerosis-prone WHHL-CA rabbits and myocardial infarction-prone WHHLMI rabbits) developed at Kobe Univers...

journal_title：Journal of atherosclerosis and thrombosis

authors： Shiomi M

更新日期：2020-02-01 00:00:00

abstract：:Coronary artery calcification (CAC) is a well-established surrogate marker of the total burden of coronary atherosclerosis. The CAC score, as measured on coronary computed tomography (CT), is associated with the prevalence of coronary artery disease (CAD) as well as cardiovascular morbidity and mortality. The CAC scor...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yamamoto H,Kitagawa T,Kihara Y

更新日期：2014-01-01 00:00:00

abstract：:The agarose gel electrophoresis and differential staining system is an easy and quick method for analyzing the serum lipid composition of each lipoprotein fraction. It has been reported in adults that measured values obtained by this method strongly correlated with those obtained by ultracentrifugation. The aim of thi...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kuromori Y,Okada T,Miyashita M,Harada K

更新日期：2006-10-01 00:00:00

abstract：AIM:Inherent mechanisms leading to vascular smooth muscle cells (VSMC) alterations in obesitylinked type 2 diabetes (T2D) situation remain to be clarified. This study evaluates the impact of supernatant of adipocytes extracted from mice fed high-fat-diets (HFD) on the proliferation and apoptosis of VSMC. METHODS:Adipo...

journal_title：Journal of atherosclerosis and thrombosis

authors： El Akoum S,Cloutier I,Tanguay JF

更新日期：2012-01-01 00:00:00

abstract：:Both hyperthyroidism and hypothyroidism affect the cardiovascular system. Hypothyroidism is known to be associated with enhanced atherosclerosis and ischemic heart diseases. The accelerated atherosclerosis in the hypothyroid state has been traditionally ascribed to atherogenic lipid profile, diastolic hypertension, an...

journal_title：Journal of atherosclerosis and thrombosis

authors： Ichiki T

更新日期：2016-01-01 00:00:00

abstract：AIM:To determine the effects of exercise training on total and high molecular weight (HMW) adiponectin and adiponectin oligomeric distribution. METHODS:A randomized parallel-design study (n=53; 40 women and 13 men; age range, 32?65 years) was conducted at a fitness club between April 2006 and July 2007. Participants w...

journal_title：Journal of atherosclerosis and thrombosis

authors： Ando D,Hosaka Y,Suzuki K,Yamagata Z

更新日期：2009-01-01 00:00:00

abstract：AIM:The adipocyte-derived hormone leptin plays a key role in the regulation of food intake and energy expenditure. Recent studies have suggested that leptin is also involved in the pathogenesis of obesity-associated atherosclerosis and cardiovascular disease. In this study, we investigated the associations of leptin an...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yamazaki Y,Emoto M,Morioka T,Kawano N,Lee E,Urata H,Tsuchikura S,Motoyama K,Mori K,Fukumoto S,Shoji T,Nishizawa Y,Inaba M

更新日期：2013-01-01 00:00:00

abstract：:To study exogenous sterol metabolism during the suppression or stimulation of cholesterol biosynthesis induced by treatments for hyperlipidemia, we determined plasma plant sterol concentrations before and after administration of an HMG-CoA reductase inhibitor, pravastatin, and compared these with changes in these plas...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hidaka H,Kojima H,Kawabata T,Nakamura T,Konaka K,Kashiwagi A,Kikkawa R,Shigeta Y

更新日期：1995-01-01 00:00:00

abstract：:Statins are the main treatment for hypercholesterolemia and the cornerstone of atherosclerotic cardiovascular disease prevention. Many patients taking statins report muscle-related symptoms, one of the most important causes of statin treatment discontinuation, which is associated with an increased risk of cardiovascul...

journal_title：Journal of atherosclerosis and thrombosis

authors： Alonso R,Cuevas A,Cafferata A

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Although insulin resistance (IR) is present in non-diabetic subjects, it is unknown whether IR affects statin treatment. We assessed the relationship between IR and the changes of lipid profile in patients with hyperlipidemia treated by atorvastatin. METHODS:Forty-four non-diabetic patients were included. H...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yoshitomi Y,Ishii T,Kaneki M,Tsujibayashi T,Sakurai S,Nagakura C,Miyauchi A

更新日期：2005-01-01 00:00:00

abstract：AIM:To study atherosclerosis risk in diabetes, we investigated ATP-binding cassette transporter A1 (ABCA1) expression and high-density lipoprotein (HDL) biogenesis in the liver and hepatocytes under hyperglycemic conditions. METHODS AND RESULTS:In streptozotocin-induced diabetic mice, plasma HDL decreased while ABCA1 ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tsujita M,Hossain MA,Lu R,Tsuboi T,Okumura-Noji K,Yokoyama S

更新日期：2017-11-01 00:00:00

abstract：AIMS:The identification and appropriate management of commercial motor vehicle (CMV) drivers with unrecognized obstructive sleep apnea (OSA) is a major public health concern and priority; OSA among drivers has not been fully investigated in Japan, and a better understanding of this undiagnosed disease is warranted. The...

journal_title：Journal of atherosclerosis and thrombosis

authors： Ueyama M,Kokuto H,Sugihara H,Oikawa S,Suzuki F,Goto H,Kudoh S

更新日期：2018-11-01 00:00:00

abstract：AIM:Individuals with type 2 diabetes are at high risk for cardiovascular events; however, a modality that could reduce risk has not been fully evaluated. We examined the annual incidence rate of cardiovascular events in asymptomatic Japanese diabetic patients who underwent gated myocardial perfusion single-photon compu...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yamasaki Y,Katakami N,Kaneto H,Nakajima K,Kusuoka H,Kashiwagi A,Nishimura T

更新日期：2013-01-01 00:00:00

abstract：AIM:The INK4b-ARF-INK4a locus in the chromosome 9p21 region is known to play an important role in the development of atherosclerosis. The INK4/ARF transcript p16(INK4a) inhibits the activity of the cyclin-dependent kinases CDK4/CDK6 and arrests cell-cycle progression. CDK inhibitors also regulate G1/S phase progression...

journal_title：Journal of atherosclerosis and thrombosis

authors： Bayoglu B,Arslan C,Gode S,Kaya Dagistanli F,Arapi B,Burc Deser S,Dirican A,Cengiz M

更新日期：2014-01-01 00:00:00

abstract：:We studied the association of six common polymorphisms of four genes related to lipid metabolism with serum lipid levels. We selected single-nucleotide polymorphisms (SNPs) in the genes for cholesteryl ester transfer protein (CETP), lipoprotein lipase (LPL), hepatic lipase (LIPC), and apolipoprotein CIII (APOC3), and ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Arai H,Yamamoto A,Matsuzawa Y,Saito Y,Yamada N,Oikawa S,Mabuchi H,Teramoto T,Sasaki J,Nakaya N,Itakura H,Ishikawa Y,Ouchi Y,Horibe H,Egashira T,Hattori H,Shirahashi N,Kita T

更新日期：2005-01-01 00:00:00

abstract：AIM:In addition to the risk of progression to end-stage renal disease (ESRD), chronic kidney disease (CKD) is also known to be associated with an elevated risk of cardiovascular disease (CVD). Statins may improve renal function in CKD patients. METHODS:The database of the LIVALO Effectiveness and Safety (LIVES) Study,...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kimura K,Shimano H,Yokote K,Urashima M,Teramoto T

更新日期：2010-06-30 00:00:00