Diagnosis and Management of Statin Intolerance.

abstract：AIM:Resveratrol has been shown to mimic the beneficial effects of dietary restriction (DR). We previously reported that DR delays stroke onset and extends the lifespan in Stroke-Prone Spontaneously Hypertensive rats (SHRSP). Therefore, we examined whether resveratrol mimics DR and delays stroke onset in SHRSP. METHODS...

journal_title：Journal of atherosclerosis and thrombosis

authors： Chiba T,Yokotani K,Suzuki S,Itoh T,Umegaki K

更新日期：2015-01-01 00:00:00

abstract：AIMS:Adiponectin, an adipocyte-specific secretory protein, abundantly exists in the blood stream while its concentration paradoxically decreases in obesity. Hypoadiponectinemia is one of risks of cardiovascular diseases. However, impact of serum adiponectin concentration on acute ischemic myocardial damages has not bee...

journal_title：Journal of atherosclerosis and thrombosis

authors： Natsukawa T,Maeda N,Fukuda S,Yamaoka M,Fujishima Y,Nagao H,Sato F,Nishizawa H,Sawano H,Hayashi Y,Funahashi T,Kai T,Shimomura I

更新日期：2017-08-01 00:00:00

abstract：AIM:Up-regulation of soluble CD40 ligand (sCD40L) and of monocyte chemoattractant protein-1 (MCP-1) has been found in diabetes and in patients with acute cerebral ischemia. We asked whether (i) the two molecules are similarly upregulated among non-lacunar and lacunar diabetic strokes and (ii) sCD40L and/or MCP-1 predic...

journal_title：Journal of atherosclerosis and thrombosis

authors： Davì G,Tuttolomondo A,Santilli F,Basili S,Ferrante E,Di Raimondo D,Pinto A,Licata G

更新日期：2009-01-01 00:00:00

abstract：AIM:It has been reported that beta-blockers (BB) reduce cardiovascular events in patients with atherosclerotic disease. However, little is known about the efficacy of these drugs in patients with critical limb ischemia (CLI). We investigated whether beta-blocker therapy affects the clinical outcomes of CLI patients. M...

journal_title：Journal of atherosclerosis and thrombosis

authors： Soga Y,Iida O,Takahara M,Hirano K,Suzuki K,Kawasaki D

更新日期：2015-01-01 00:00:00

abstract：:Blood lipid levels are highly heritable and modifiable risk factors for coronary artery disease (CAD), and are the leading cause of death worldwide. These facts have motivated human genetic association studies that have the substantial potential to define the risk factors that are causal and to identify pathways and t...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tada H,Kawashiri MA,Konno T,Yamagishi M,Hayashi K

更新日期：2016-01-01 00:00:00

abstract：AIM:Epicardial adipose tissue (EAT) is implicated in the development of coronary atherosclerosis.We sought to investigate the association between the EAT thickness and presence of multivessel disease (MV) in patients with acute myocardial infarction (AMI). METHODS:We enrolled 45 consecutive patients with AMI who under...

journal_title：Journal of atherosclerosis and thrombosis

authors： Fukamachi D,Higuchi Y,Hiro T,Takayama T,Kanai T,Sudo M,Nishida T,Iida K,Saito S,Hirayama A

更新日期：2015-01-01 00:00:00

abstract：AIM:The Japan EPA Lipid Intervention Study (JELIS) reported a 19% reduction of the risk for coronary artery disease after long-term use of pure eicosapentaenoic acid (EPA) in Japanese patients with hypercholesterolemia. The variation in plasma fatty acid composition influenced the risk of coronary events. The aim of th...

journal_title：Journal of atherosclerosis and thrombosis

authors： Itakura H,Yokoyama M,Matsuzaki M,Saito Y,Origasa H,Ishikawa Y,Oikawa S,Sasaki J,Hishida H,Kita T,Kitabatake A,Nakaya N,Sakata T,Shimada K,Shirato K,Matsuzawa Y,JELIS.

更新日期：2012-01-01 00:00:00

abstract：AIM:Asymmetric dimethylarginine(ADMA) has recently been investigated as a risk marker for cardio- and cerebrovascular diseases. However, it is not currently known whether the ADMA levels are related to the risk of stroke in Japanese women. METHODS:We examined 192 Japanese women(mean age, 55±9 years, range, 40-80 years...

journal_title：Journal of atherosclerosis and thrombosis

authors： Muraga K,Nishiyama Y,Otsuka T,Ueda M,Abe A,Katayama Y

更新日期：2014-01-01 00:00:00

abstract：AIM:Paraoxonase-1 (PON1) is an antioxidant enzyme located in high density lipoprotein (HDL). PON1 was defined as a protective factor against atherosclerosis. The aim of this study was to investigate the possible relationship between serum paraoxonase (PONase), homocysteine thiolactonase (HTase) activities and PON1 Q192...

journal_title：Journal of atherosclerosis and thrombosis

authors： Bayrak A,Bayrak T,Tokgözoglu SL,Volkan-Salanci B,Deniz A,Yavuz B,Alikasifoglu M,Demirpençe E

更新日期：2012-01-01 00:00:00

abstract：AIM:Patients with acute infectious diseases are at an increased risk of venous thromboembolism (VTE). Clinicians should be aware of the VTE risk in patients with COVID-19, many of whom present with severe coagulation disorders. METHOD:We used an online platform to conduct a cross-sectional questionnaire survey among d...

journal_title：Journal of atherosclerosis and thrombosis

authors： Zhang Z,Xi L,Zhang S,Zhang Y,Pang W,Wang Y,Li C,Zhai Z,Wang C

更新日期：2020-10-01 00:00:00

abstract：:Several reports have suggested that HDL has anti-oxidative actions. We investigated the relationship between HDL-cholesterol (HDL-C) and malondialdehyde-modified LDL (MDA-LDL) concentrations using enzyme linked immunosolvent assay. We divided our study subjects into four groups on the basis of concentrations of trigly...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kondo A,Li J,Manabe M,Saito K,Kanno T,Maekawa M

更新日期：2003-01-01 00:00:00

abstract：:In atherosclerotic lesions, matrix metalloproteinases produced by foam cells (macrophages) are thought to increase plaque instability, promote plaque rupture, by degradating extracellular matrix. To investigate the relationship between the expression of these proteinases and the histologic appearance of atheromas, imm...

journal_title：Journal of atherosclerosis and thrombosis

authors： Okamoto Y,Satomura K,Ohsuzu F,Nakamura H,Takeuchi K,Yoshioka M

更新日期：2001-01-01 00:00:00

abstract：AIM:The Japan EPA Lipid Intervention Study (JELIS) was the first prospective randomized clinical trial to demonstrate prevention of coronary events by pure eicosapentaenoic acid (EPA). The aim of this study was to examine the relationships between various plasma fatty acid concentrations and the risk of coronary events...

journal_title：Journal of atherosclerosis and thrombosis

authors： Itakura H,Yokoyama M,Matsuzaki M,Saito Y,Origasa H,Ishikawa Y,Oikawa S,Sasaki J,Hishida H,Kita T,Kitabatake A,Nakaya N,Sakata T,Shimada K,Shirato K,Matsuzawa Y,JELIS Investigators.

更新日期：2011-01-01 00:00:00

abstract：AIM:Adipose tissue inflammation induced by macrophage infiltration through the MCP-1/CCR2 pathway is considered to play a pivotal role in the development of visceral obesity and insulin resistance. In the present study, therefore, we examined whether pharmacological inhibition of CCR2 is effective against the developme...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tamura Y,Sugimoto M,Murayama T,Minami M,Nishikaze Y,Ariyasu H,Akamizu T,Kita T,Yokode M,Arai H

更新日期：2010-03-31 00:00:00

abstract：AIM:Although metformin treatment has been reported to reduce the risk of cardiovascular events in patients with type 2 diabetes, the underlying mechanisms have not been elucidated fully. Here we assessed atherosclerotic lesion formation in newly established 2 mouse lines with different blood glucose levels (Oikawa-Naga...

journal_title：Journal of atherosclerosis and thrombosis

authors： Asai A,Shuto Y,Nagao M,Kawahara M,Miyazawa T,Sugihara H,Oikawa S

更新日期：2019-12-01 00:00:00

abstract：:The aim was to give on overview of the profile of cardiovascular disease, vascular pathology and the relationships between lifestyle and cardiovascular disease in Japanese. Compared with the United States and Europe, the higher mortality from stroke and lower mortality from coronary heart disease constitute a unique c...

journal_title：Journal of atherosclerosis and thrombosis

authors： Iso H

更新日期：2011-01-01 00:00:00

abstract：AIM:This study was designed to analyze microparticles (MPs) from endothelial cells (EMPs) and immune cells from healthy individuals and paitents with Takayasu arteritis (TA), and any possible relationships between MPs and TA acitivity. METHODS:MPs derived from the plasma of 51 subjects were analyzed, including 32 pati...

journal_title：Journal of atherosclerosis and thrombosis

authors： Cheng X,Dang A,Lv N,Zhao T

更新日期：2019-06-01 00:00:00

abstract：AIM:Carotid intima-media thickness (CIMT) measurements are used as a disease outcome in randomized controlled trials that assess the effects of lipid-modifying treatment. It is unclear whether common CIMT or mean maximum CIMT should be used as the primary outcome. We directly compared both measurements using aspects th...

journal_title：Journal of atherosclerosis and thrombosis

authors： Dogan S,Kastelein JJ,Grobbee DE,Bots ML

更新日期：2011-01-01 00:00:00

abstract：AIM:Ultrasound protocols to measure carotid intima media thickness (CIMT) differ considerably with regard to the inclusion of the number of carotid segments and angles used. Detailed information on the completeness of CIMT information is often lacking in published reports, and at most, overall percentages are presented...

journal_title：Journal of atherosclerosis and thrombosis

authors： Dogan S,Duivenvoorden R,Grobbee DE,Kastelein JJ,Shear CL,Evans GW,Visseren FL,Bots ML,Radiance 1 and 2 Study Groups.

更新日期：2010-05-01 00:00:00

abstract：AIM:The aim of the current study was to investigate circulating adiponectin levels and their associated factors in young lean healthy Japanese women. METHODS:We recruited 82 healthy Japanese women in their twenties and thirties with their body mass index <25 kg/m(2), and performed anthropometric, sphygmomanometric, an...

journal_title：Journal of atherosclerosis and thrombosis

authors： Takahara M,Katakami N,Kishida K,Kaneto H,Funahashi T,Shimomura I,Matsunaga S,Kubo S,Fukamizu H,Otsuka A,Ichihara K,Nakamura T

更新日期：2013-01-01 00:00:00

abstract：AIM:Inter-arm blood pressure difference (IAD) is known to be associated with a composite of cardiovascular disease (CVD) and with CVD risk factors. However, only limited information is available regarding the contribution of diabetes mellitus to IAD and the association of IAD with individual CVDs, such as coronary arte...

journal_title：Journal of atherosclerosis and thrombosis

authors： Miyashima M,Shoji T,Kakutani Y,Yamazaki Y,Ochi A,Morioka T,Shinohara-Mitsuki K,Fukumoto S,Shioi A,Inaba M,Emoto M

更新日期：2020-08-01 00:00:00

abstract：AIM:Increased levels of small dense low-density lipoproteins (sd-LDL) have been reported more atherogenic compared to total low-density lipoprotein (LDL); however, no definitive experiments using macrophages have examined this concept in vitro. METHOD AND RESULT:In this study, we isolated fractions of total LDL (densi...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tani M,Kawakami A,Mizuno Y,Imase R,Ito Y,Kondo K,Ishii H,Yoshida M

更新日期：2011-01-01 00:00:00

abstract：:Although the human liver comprises approximately 2.8% of the body weight, it plays a central role in the control of energy metabolism. While the biochemistry of energy substrates such as glucose, fatty acids, and ketone bodies in the liver is well understood, many aspects of the overall control system for hepatic meta...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yahagi N

更新日期：2017-01-01 00:00:00

abstract：AIM:Angiotensin-converting enzyme inhibitors (ACEIs) have been shown to block matrix metalloproteinase (MMP)-9 activity, which plays a role in atherogenesis. MMP-9 activity of macrophages is increased during foam cell formation. To investigate the contribution of ACEIs to foam cell formation, we studied the effects of ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kojima C,Ino J,Ishii H,Nitta K,Yoshida M

更新日期：2010-02-01 00:00:00

abstract：AIM:Since we previously reported that lower levels of HDL-C may be most useful for predicting coronary artery disease (CAD) as assessed by multi-detector row computed tomography (MDCT), we sought to confirm, among the levels of LDL-C, HDL-C, non-HDL-C (total cholesterol minus HDL-C) and the ratio of LDL-C to HDL-C (LDL...

journal_title：Journal of atherosclerosis and thrombosis

authors： Shiga Y,Miura S,Mitsutake R,Kawamura A,Uehara Y,Saku K

更新日期：2010-08-31 00:00:00

abstract：AIM:The arterial pressure-volume index (API) and arterial velocity-pulse index (AVI) are novel measurement indices of arterial stiffness. This study was performed to examine the screening validity of the API and AVI for preclinical atherosclerosis in Japanese community-dwelling adults. METHODS:We conducted a cross-sec...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yamanashi H,Koyamatsu J,Nagayoshi M,Shimizu Y,Kawashiri SY,Kondo H,Fukui S,Tamai M,Maeda T

更新日期：2018-09-01 00:00:00

abstract：AIM:All health insurers in Japan are mandated to provide Specific Health Checkups and Specific Health Guidance (SHG) focusing on metabolic syndrome (MetS) in middle-aged adults, beginning in 2008; intensive HG for individuals who have abdominal obesity and two or more additional MetS risk factors, and motivational HG f...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tsushita K,S Hosler A,Miura K,Ito Y,Fukuda T,Kitamura A,Tatara K

更新日期：2018-04-01 00:00:00

abstract：AIM:The clinical relevance of the suggested pleiotropic effects of hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) is controversial. Aggressive statins effectively reduce lipid levels, but whether their other effects are more powerful than those of regular statins is unknown. METHODS:We enrolled 32 pat...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hoshiga M,Arishiro K,Nakakoji T,Miyazaki N,Negoro N,Okabe T,Kohbayashi E,Ishihara T,Hanafusa T

更新日期：2010-07-30 00:00:00

abstract：:Oxidative stress induced by reactive oxygen species (ROS) plays an important role in atherogenesis, and the redox state is determined by the balance between antioxidants and the ROS generating system. To defend against enhanced ROS, mammalian cells have a complex network of antioxidant enzymes such as superoxide dismu...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kobayashi S,Inoue N,Azumi H,Seno T,Hirata K,Kawashima S,Hayashi Y,Itoh H,Yokozaki H,Yokoyama M

更新日期：2002-01-01 00:00:00

abstract：AIM:The prognostic value of homocysteine (HCY) in patients with coronary artery diseases (CAD) is still controversial. The objective of this study was to investigate whether elevated HCY level at admission predict long-term outcomes in patients after percutaneous coronary interventions (PCI) with coronary artery stenti...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yeh JK,Chen CC,Hsieh MJ,Tsai ML,Yang CH,Chen DY,Chang SH,Wang CY,Lee CH,Hsieh IC

更新日期：2017-07-01 00:00:00