Urinary 8-Hydroxy-2'-Deoxyguanosine Levels and Cardiovascular Disease Incidence in Japan.

abstract：AIM:To determine the effects of exercise training on total and high molecular weight (HMW) adiponectin and adiponectin oligomeric distribution. METHODS:A randomized parallel-design study (n=53; 40 women and 13 men; age range, 32?65 years) was conducted at a fitness club between April 2006 and July 2007. Participants w...

journal_title：Journal of atherosclerosis and thrombosis

authors： Ando D,Hosaka Y,Suzuki K,Yamagata Z

更新日期：2009-01-01 00:00:00

abstract：AIMS:Patients with chronic kidney disease (CKD) have a higher burden of cardiovascular morbidity and mortality than the general population. Endothelial dysfunction has been suggested to play a role in both glomerular filtration rate loss and cardiovascular damage. Thus, the present study aimed to evaluate the relations...

journal_title：Journal of atherosclerosis and thrombosis

authors： Li Y,Cui R,Liu K,Eshak ES,Cui M,Dong J,Imano H,Muraki I,Kiyama M,Kitamura A,Okada T,Yamagishi K,Umesawa M,Ohira T,Iso H,CIRCS investigators.

更新日期：2020-09-02 00:00:00

abstract：AIM:A new antibody reacted with an epitope in Lp(a) that has undergone oxidation treatment, but is not present in native Lp(a), was developed. Thus, we determined serum oxidized Lp(a) concentration in healthy volunteers, and coronary artery disease (CAD), diabetes mellitus (DM), and hypertensive patients. METHODS:We m...

journal_title：Journal of atherosclerosis and thrombosis

authors： Morishita R,Ishii J,Kusumi Y,Yamada S,Komai N,Ohishi M,Nomura M,Hishida H,Niihashi M,Mitsumata M

更新日期：2009-08-01 00:00:00

abstract：AIM:Recent studies have suggested that hyperinsulinemia is associated with high cardiovascular risk. The purpose of this study was to assess the relationship between the serum insulin level and coronary artery calcification (CAC). METHODS:We performed a cross-sectional study of 582 consecutive and nondiabetic particip...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tanaka M,Fukui M,Tomiyasu K,Akabame S,Nakano K,Hasegawa G,Oda Y,Nakamura N

更新日期：2010-10-27 00:00:00

abstract：AIM:Ezetimibe, an inhibitor of cholesterol intestinal absorption, is a lipid lowering agent. However, anti-atherogenic effects of ezetimibe have not been fully elucidated. Therefore, the objective in this study was to clarify the vascular protective effects of ezetimibe in patients with hypercholesterolemia. METHODS:E...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kurobe H,Aihara K,Higashida M,Hirata Y,Nishiya M,Matsuoka Y,Kanbara T,Nakayama T,Kinoshita H,Sugano M,Fujimoto E,Kurobe A,Sugasawa N,Kitaichi T,Akaike M,Sata M,Matsumoto T,Kitagawa T

更新日期：2011-01-01 00:00:00

abstract：AIM:The clinical relevance of the suggested pleiotropic effects of hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) is controversial. Aggressive statins effectively reduce lipid levels, but whether their other effects are more powerful than those of regular statins is unknown. METHODS:We enrolled 32 pat...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hoshiga M,Arishiro K,Nakakoji T,Miyazaki N,Negoro N,Okabe T,Kohbayashi E,Ishihara T,Hanafusa T

更新日期：2010-07-30 00:00:00

abstract：:Inflammation and oxidative stress play key roles in atherosclerotic plaque instability, and plaque rupture/erosion and subsequent thrombus formation constitute the principal mechanisms of total vessel occlusion and acute ST-elevation myocardial infarction (STEMI). Plaque disruption triggers the formation of initial pl...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yunoki K,Naruko T,Sugioka K,Inaba M,Itoh A,Haze K,Yoshiyama M,Ueda M

更新日期：2013-01-01 00:00:00

abstract：AIM:The Japan EPA Lipid Intervention Study (JELIS) was the first prospective randomized clinical trial to demonstrate prevention of coronary events by pure eicosapentaenoic acid (EPA). The aim of this study was to examine the relationships between various plasma fatty acid concentrations and the risk of coronary events...

journal_title：Journal of atherosclerosis and thrombosis

authors： Itakura H,Yokoyama M,Matsuzaki M,Saito Y,Origasa H,Ishikawa Y,Oikawa S,Sasaki J,Hishida H,Kita T,Kitabatake A,Nakaya N,Sakata T,Shimada K,Shirato K,Matsuzawa Y,JELIS Investigators.

更新日期：2011-01-01 00:00:00

abstract：AIMS:Statins not only reduce low-density lipoprotein (LDL) cholesterol, but also prevent the progression of kidney dysfunction. Ezetimibe, a cholesterol-absorption inhibitor, also lowers LDL cholesterol levels when added to statins; however, the effect of add-on ezetimibe on kidney function has had conflicting results....

journal_title：Journal of atherosclerosis and thrombosis

authors： Kinouchi K,Ichihara A,Bokuda K,Morimoto S,Itoh H

更新日期：2013-01-01 00:00:00

abstract：:Although abdominal obesity or visceral obesity is considered to be one of the components of metabolic syndrome and to have an important role in a cluster of cardiovascular risks, there is no consensus about the definition and diagnostic criteria for this syndrome, probably because there is considerable disagreement ab...

journal_title：Journal of atherosclerosis and thrombosis

authors： Matsuzawa Y,Funahashi T,Nakamura T

更新日期：2011-01-01 00:00:00

abstract：AIMS:The present study aimed to determine the epidemiological aspects of medico-legal autopsies and manifestation of coronary atherosclerosis. METHODS:This was a cross sectional study involving 222 cases recruited from National Institute of Forensic Medicine (NIFM) Hospital Kuala Lumpur (HKL) and Department of Forensi...

journal_title：Journal of atherosclerosis and thrombosis

authors： Rahimi R,Singh MKC,Noor NM,Omar E,Noor SM,Mahmood MS,Abdullah N,Nawawi HM

更新日期：2018-05-01 00:00:00

abstract：AIM:To investigate the association between arterial stiffness (present with brachial-ankle pulse wave velocity (baPWV)) and metabolic syndrome (MetS) in a population-based study of middle-aged Chinese. METHODS:MetS was defined using the AHA/NHLBI criteria. A total of 1,018 subjects aged 40 years and over were recruite...

journal_title：Journal of atherosclerosis and thrombosis

authors： Lin WY,Lai MM,Li CI,Lin CC,Li TC,Chen CC,Lin T,Liu CS

更新日期：2009-04-01 00:00:00

abstract：:The agarose gel electrophoresis and differential staining system is an easy and quick method for analyzing the serum lipid composition of each lipoprotein fraction. It has been reported in adults that measured values obtained by this method strongly correlated with those obtained by ultracentrifugation. The aim of thi...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kuromori Y,Okada T,Miyashita M,Harada K

更新日期：2006-10-01 00:00:00

abstract：:Blood lipid levels are highly heritable and modifiable risk factors for coronary artery disease (CAD), and are the leading cause of death worldwide. These facts have motivated human genetic association studies that have the substantial potential to define the risk factors that are causal and to identify pathways and t...

journal_title：Journal of atherosclerosis and thrombosis

authors： Tada H,Kawashiri MA,Konno T,Yamagishi M,Hayashi K

更新日期：2016-01-01 00:00:00

abstract：:Arterial stiffness is increased in type 2 diabetes mellitus, and diabetes preferentially affects arterial stiffness of the central (elastic, capacitive) over peripheral (muscular, conduit) arteries. We hypothesized that arterial stiffness of the central artery may be more closely associated with ischemic heart disease...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hatsuda S,Shoji T,Shinohara K,Kimoto E,Mori K,Fukumoto S,Koyama H,Emoto M,Nishizawa Y

更新日期：2006-04-01 00:00:00

abstract：AIM:To demonstrate the clinical benefit of inhibiting intestinal cholesterol absorption, we evaluated the effects of ezetimibe on surrogate markers of cholesterol absorption and synthesis, lipid and glucose metabolism, and markers of obesity and inflammation. METHODS:A total of 120 patients with dyslipidemia (46 men; ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hiramitsu S,Ishiguro Y,Matsuyama H,Yamada K,Kato K,Noba M,Uemura A,Yoshida S,Matsubara Y,Kani A,Hasegawa K,Hishida H,Ozaki Y

更新日期：2010-02-01 00:00:00

abstract：AIM:Recent evidence suggests that small dense low-density lipoprotein (sd-LDL) particles are more atherogenic than large-LDL in spite of their lower cholesterol content. This study aimed to determine whether sd-LDL-cholesterol (sd-LDL-C) is superior to LDL-C as a biomarker of coronary heart disease (CHD). METHODS:LDL ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Koba S,Yokota Y,Hirano T,Ito Y,Ban Y,Tsunoda F,Sato T,Shoji M,Suzuki H,Geshi E,Kobayashi Y,Katagiri T

更新日期：2008-10-01 00:00:00

abstract：:To determine the recent serum lipid levels and other serum variables in the general Japanese population and trends in their changes over the past 40 years, a nationwide survey of serum lipid levels was conducted in 36 institutes from various districts around Japan in 2000. The total number of subjects was 12,839, aged...

journal_title：Journal of atherosclerosis and thrombosis

authors： Arai H,Yamamoto A,Matsuzawa Y,Saito Y,Yamada N,Oikawa S,Mabuchi H,Teramoto T,Sasaki J,Nakaya N,Itakura H,Ishikawa Y,Ouchi Y,Horibe H,Kita T

更新日期：2005-01-01 00:00:00

abstract：AIM:Increasing evidence indicates that antimicrobial peptides, human neutrophil peptide-1, -2, and -3 (HNP1-3) and human antimicrobial peptide LL-37 are involved in the pathophysiology of atherosclerosis; however, little is known about their circulating protein levels in acute myocardial infarction (AMI). We therefore ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Zhao H,Yan H,Yamashita S,Li W,Liu C,Chen Y,Zhou P,Chi Y,Wang S,Zhao B,Song L

更新日期：2012-01-01 00:00:00

abstract：AIM:To examine the impact of C-reactive protein on the risks of stroke and its subtypes, particularly among Asian populations in which median C-reactive protein levels are typically lower than in Western populations. METHODS:A prospective, nested case-control study was conducted to examine the associations between hig...

journal_title：Journal of atherosclerosis and thrombosis

authors： Iso H,Noda H,Ikeda A,Yamagishi K,Inoue M,Iwasaki M,Tsugane S

更新日期：2012-01-01 00:00:00

abstract：:Patients with chronic kidney disease (CKD) are at an increased risk not only for end-stage kidney disease (ESKD) but also for cardiovascular disease (CVD). In this review article, we summarize the current evidence of CKD as a high-risk condition for CVD based on reports from Japan and other countries to draw attention...

journal_title：Journal of atherosclerosis and thrombosis

authors： Shoji T,Abe T,Matsuo H,Egusa G,Yamasaki Y,Kashihara N,Shirai K,Kashiwagi A,Committee of Renal and Peripheral Arteries, Japan Atherosclerosis Society.

更新日期：2012-01-01 00:00:00

abstract：:Bilirubin is a fundamental metabolic end product of heme degradation. Despite acting as a cytotoxic metabolite at high concentrations, bilirubin at physiological concentrations has antioxidant effects, such as scavenging reactive oxygen species, leading to a decrease in oxidative stress. Endothelial dysfunction is an ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Maruhashi T,Kihara Y,Higashi Y

更新日期：2019-08-01 00:00:00

abstract：AIM:This study was designed to analyze microparticles (MPs) from endothelial cells (EMPs) and immune cells from healthy individuals and paitents with Takayasu arteritis (TA), and any possible relationships between MPs and TA acitivity. METHODS:MPs derived from the plasma of 51 subjects were analyzed, including 32 pati...

journal_title：Journal of atherosclerosis and thrombosis

authors： Cheng X,Dang A,Lv N,Zhao T

更新日期：2019-06-01 00:00:00

abstract：AIMS:Profiling of lipoproteins can predict risk of cardiovascular disease; gel permeation high-performance liquid chromatography (HPLC) improves prediction accuracy by providing detailed data for specific lipoprotein subclasses. This study applied HPLC to examine the effects of evolocumab, which effectively treats hype...

journal_title：Journal of atherosclerosis and thrombosis

authors： Masuda D,Kiyosue A,Hirayama A,Shimauchi J,López JAG,Miyawaki K,Yamashita S

更新日期：2020-11-01 00:00:00

abstract：AIM:Withholding effective treatment is clinically prevalent. The CEntralized Pan-Asian survey on tHE Under-treatment of hypercholeSterolemia (CEPHEUS-PA) indicated suboptimal low-density lipoprotein cholesterol (LDL-C) goal attainment in Taiwan, which may be attributable to clinical inertia. We herein analyzed the Taiw...

journal_title：Journal of atherosclerosis and thrombosis

authors： Wang KL,Wu CH,Wang KF,Chang CC,Chen LC,Lu TM,Lin SJ,Chiang CE

更新日期：2014-01-01 00:00:00

abstract：AIM:To examine the association between renal vasculature changes and generalized atherosclerosis using autopsy cases. METHODS:We histologically examined 107 autopsy patients(mean age, 68.4 years; 64% men; 81% non-CVD) to investigate the association between renal vasculature changes and generalized atherosclerosis. We ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Iwakiri T,Sato Y,Matsuura Y,Hatakeyama K,Marutsuka K,Yamashita A,Fujimoto S,Kitamura K,Asada Y

更新日期：2014-01-01 00:00:00

abstract：:The effects of combination therapy of angiotensin II receptor blockers (ARBs) and a calcium antagonist, benidipine hydrochloride, on glucose and lipid metabolism and pulse pressure were studied in elderly hypertensive patients with type 2 diabetes mellitus. Twenty-five hypertensive diabetic patients aged 65 years or o...

journal_title：Journal of atherosclerosis and thrombosis

authors： Sasaki H,Kanai S,Oyama T,Miyashita Y,Yamamura S,Shirai K

更新日期：2006-06-01 00:00:00

abstract：AIM:Nephrotic syndrome (NS) is associated with an increased rate of cardiovascular events. The YKL-40 level is associated with atherosclerosis, endothelial dysfunction and proteinuria in renal and non-renal populations. The aim of this study was to investigate the relationships between the YKL-40 level and both vascula...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kocyigit I,Gungor O,Dogan E,Karadavut S,Karakukcu C,Eroglu E,Orscelik O,Unal A,Dogan A,Sipahioglu MH,Tokgoz B,Oymak O

更新日期：2015-01-01 00:00:00

abstract：:In atherosclerotic lesions, matrix metalloproteinases produced by foam cells (macrophages) are thought to increase plaque instability, promote plaque rupture, by degradating extracellular matrix. To investigate the relationship between the expression of these proteinases and the histologic appearance of atheromas, imm...

journal_title：Journal of atherosclerosis and thrombosis

authors： Okamoto Y,Satomura K,Ohsuzu F,Nakamura H,Takeuchi K,Yoshioka M

更新日期：2001-01-01 00:00:00

abstract：AIM:We examined the effects of mild hyperbaric oxygen on the properties of the soleus muscle in rats with metabolic syndrome. METHODS:Five-week-old metabolic syndrome (SHR/NDmcr-cp, cp/cp) rats were divided into normobaric (CP) and mild hyperbaric oxygen (CP-H) groups (n=5/group). In addition, 5-week-old Wistar rats w...

journal_title：Journal of atherosclerosis and thrombosis

authors： Takemura A,Ishihara A

更新日期：2017-01-01 00:00:00