Expression of matrix metalloproteinase 3 in experimental atherosclerotic plaques.

abstract：AIM:We investigated whether any seasonal variation is observed in the incidence, severity and prognosis of critical limb ischemia (CLI) requiring endovascular therapy. METHODS:We analyzed a multicenter database of 1,568 consecutive CLI cases undergoing primary endovascular therapy for infrainguinal lesions between Jul...

journal_title：Journal of atherosclerosis and thrombosis

authors： Takahara M,Iida O,Soga Y,Hirano K,Yamaoka T,Kawasaki D,Suzuki K,Suematsu N,Shintani Y,Miyashita Y,Kaneto H,Shimomura I

更新日期：2013-01-01 00:00:00

abstract：AIM:The Vietnamese develop type 2 diabetes (T2D) and metabolic syndrome (MS) at a lower BMI than other ethnicities. Thus, biomarkers that identify subjects at an increased risk of T2D independently of obesity are being sought. Recent studies show that circulating NO metabolites (NOx) are increased in T2D. We investigat...

journal_title：Journal of atherosclerosis and thrombosis

authors： Binh PN,Abe Y,Tien PG,Son le NT,Hanh TT,Diep do TN,Qui le TK,Kawano M,Maruyama C

更新日期：2011-01-01 00:00:00

abstract：:Dysregulation of adipose tissue-derived bioactive molecules, termed adipokines, is recognized as common ground for insulin resistance and metabolic syndrome associated with obesity. However, adipokine dysregulation is paradoxically associated with lipodystrophy and lipoatrophy with aging. In familial partial lipodystr...

journal_title：Journal of atherosclerosis and thrombosis

authors： Arai Y,Takayama M,Abe Y,Hirose N

更新日期：2011-01-01 00:00:00

abstract：AIM:To develop and validate a new risk prediction model for predicting the 10-year risk of atherosclerotic cardiovascular disease (ASCVD) in Japanese adults. METHODS:A total of 2,454 participants aged 40-84 years without a history of cardiovascular disease (CVD) were prospectively followed up for 24 years. An incident...

journal_title：Journal of atherosclerosis and thrombosis

authors： Honda T,Chen S,Hata J,Yoshida D,Hirakawa Y,Furuta Y,Shibata M,Sakata S,Kitazono T,Ninomiya T

更新日期：2021-01-22 00:00:00

abstract：AIM:To demonstrate the clinical benefit of inhibiting intestinal cholesterol absorption, we evaluated the effects of ezetimibe on surrogate markers of cholesterol absorption and synthesis, lipid and glucose metabolism, and markers of obesity and inflammation. METHODS:A total of 120 patients with dyslipidemia (46 men; ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Hiramitsu S,Ishiguro Y,Matsuyama H,Yamada K,Kato K,Noba M,Uemura A,Yoshida S,Matsubara Y,Kani A,Hasegawa K,Hishida H,Ozaki Y

更新日期：2010-02-01 00:00:00

abstract：AIM:Homocysteine is associated with increased arterial resistance and eventually causes luminal reduction. The purpose of the present study was to evaluate an association between the plasma concentration of total homocysteine (tHcy) and stenosis or occlusion of the internal carotid artery (ICA) in patients with ischemi...

journal_title：Journal of atherosclerosis and thrombosis

authors： Jeong SK,Seo JY,Cho YI

更新日期：2010-09-30 00:00:00

abstract：AIM:Because the prevalence of hyperuricemia is lower in females than in males, the association between hyperuricemia and cardiovascular disease has been frequently reported in females. Increased serum uric acid levels are associated with the presence of cardiovascular risk factors such as hypertension, renal dysfunctio...

journal_title：Journal of atherosclerosis and thrombosis

authors： Ando K,Takahashi H,Watanabe T,Daidoji H,Otaki Y,Nishiyama S,Arimoto T,Shishido T,Miyashita T,Miyamoto T,Kubota I

更新日期：2016-08-01 00:00:00

abstract：AIM:Paraoxonase-1 (PON1) is an antioxidant enzyme located in high density lipoprotein (HDL). PON1 was defined as a protective factor against atherosclerosis. The aim of this study was to investigate the possible relationship between serum paraoxonase (PONase), homocysteine thiolactonase (HTase) activities and PON1 Q192...

journal_title：Journal of atherosclerosis and thrombosis

authors： Bayrak A,Bayrak T,Tokgözoglu SL,Volkan-Salanci B,Deniz A,Yavuz B,Alikasifoglu M,Demirpençe E

更新日期：2012-01-01 00:00:00

abstract：AIM:Resistin is an adipocytokine that may link inflammation and atherosclerosis.We studied the associations of resistin levels with cardiovascular events and restenosis. METHODS:We measured pre-procedural serum resistin levels in 140 patients with coronary artery disease undergoing elective percutaneous coronary inter...

journal_title：Journal of atherosclerosis and thrombosis

authors： Momiyama Y,Ohmori R,Uto-Kondo H,Tanaka N,Kato R,Taniguchi H,Arakawa K,Nakamura H,Ohsuzu F

更新日期：2011-01-01 00:00:00

abstract：AIM:The association between urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), an oxidative stress marker, and the incidence of cardiovascular disease (CVD) has not been confirmed because no previous studies evaluated 24-hour 8-OHdG excretion levels in the general population. We aimed to confirm the association between 24-h...

journal_title：Journal of atherosclerosis and thrombosis

authors： Nagao M,Kobashi G,Umesawa M,Cui R,Yamagishi K,Imano H,Okada T,Kiyama M,Kitamura A,Sairenchi T,Haruyama Y,Ohira T,Iso H,CIRCS Investigators.

更新日期：2020-10-01 00:00:00

abstract：AIM:Changes in indexes of obesity, such as waist circumference (WC) and body mass index (BMI), may influence some glucose metabolism-related parameters in both obese and non-obese subjects. We have investigated the impact of changes in WC and in BMI on data related to glucose metabolism over a one-year period. METHODS...

journal_title：Journal of atherosclerosis and thrombosis

authors： Sakamoto A,Ishizaka Y,Toda E,Nagai R,Koike K,Yamakado M,Ishizaka N

更新日期：2010-12-26 00:00:00

abstract：AIM:Inter-arm blood pressure difference (IAD) is known to be associated with a composite of cardiovascular disease (CVD) and with CVD risk factors. However, only limited information is available regarding the contribution of diabetes mellitus to IAD and the association of IAD with individual CVDs, such as coronary arte...

journal_title：Journal of atherosclerosis and thrombosis

authors： Miyashima M,Shoji T,Kakutani Y,Yamazaki Y,Ochi A,Morioka T,Shinohara-Mitsuki K,Fukumoto S,Shioi A,Inaba M,Emoto M

更新日期：2020-08-01 00:00:00

abstract：:The purpose of the present study was to investigate the relationship between insulin resistance, sex hormones and sex hormone-binding globulin (SHBG) in regard to the serum lipid and lipoprotein profiles of 82 Japanese postmenopausal women. A multiple regression analysis for lipids, lipoproteins, and apoproteins as de...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kumagai S,Kai Y,Sasaki H

更新日期：2001-01-01 00:00:00

abstract：AIM:Heterozygous patients with familial hypercholesterolemia (FH) are known to be associated with a high risk of coronary artery disease (CAD), which is a major determinant of their clinical outcome. The prognosis of heterozygous FH patients substantially varies, being dependent on the level of their CAD risk, and thei...

journal_title：Journal of atherosclerosis and thrombosis

authors： Sugisawa T,Okamura T,Makino H,Watanabe M,Kishimoto I,Miyamoto Y,Iwamoto N,Yamamoto A,Yokoyama S,Harada-Shiba M

更新日期：2012-01-01 00:00:00

abstract：AIM:The arterial pressure-volume index (API) and arterial velocity-pulse index (AVI) are novel measurement indices of arterial stiffness. This study was performed to examine the screening validity of the API and AVI for preclinical atherosclerosis in Japanese community-dwelling adults. METHODS:We conducted a cross-sec...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yamanashi H,Koyamatsu J,Nagayoshi M,Shimizu Y,Kawashiri SY,Kondo H,Fukui S,Tamai M,Maeda T

更新日期：2018-09-01 00:00:00

abstract：AIMS:Patients with chronic kidney disease (CKD) have a higher burden of cardiovascular morbidity and mortality than the general population. Endothelial dysfunction has been suggested to play a role in both glomerular filtration rate loss and cardiovascular damage. Thus, the present study aimed to evaluate the relations...

journal_title：Journal of atherosclerosis and thrombosis

authors： Li Y,Cui R,Liu K,Eshak ES,Cui M,Dong J,Imano H,Muraki I,Kiyama M,Kitamura A,Okada T,Yamagishi K,Umesawa M,Ohira T,Iso H,CIRCS investigators.

更新日期：2020-09-02 00:00:00

abstract：AIM:Recent evidence suggests that small dense low-density lipoprotein (sd-LDL) particles are more atherogenic than large-LDL in spite of their lower cholesterol content. This study aimed to determine whether sd-LDL-cholesterol (sd-LDL-C) is superior to LDL-C as a biomarker of coronary heart disease (CHD). METHODS:LDL ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Koba S,Yokota Y,Hirano T,Ito Y,Ban Y,Tsunoda F,Sato T,Shoji M,Suzuki H,Geshi E,Kobayashi Y,Katagiri T

更新日期：2008-10-01 00:00:00

abstract：:Measurement of arterial stiffness in routine medical practice is important to assess the progression of arteriosclerosis. So far, many parameters have been proposed to quantitatively represent arterial stiffness. Among these, pulse wave velocity (PWV) has been most frequently applied to clinical medicine because those...

journal_title：Journal of atherosclerosis and thrombosis

authors： Saiki A,Sato Y,Watanabe R,Watanabe Y,Imamura H,Yamaguchi T,Ban N,Kawana H,Nagumo A,Nagayama D,Ohira M,Endo K,Tatsuno I

更新日期：2016-01-01 00:00:00

abstract：AIM:To examine the association between renal vasculature changes and generalized atherosclerosis using autopsy cases. METHODS:We histologically examined 107 autopsy patients(mean age, 68.4 years; 64% men; 81% non-CVD) to investigate the association between renal vasculature changes and generalized atherosclerosis. We ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Iwakiri T,Sato Y,Matsuura Y,Hatakeyama K,Marutsuka K,Yamashita A,Fujimoto S,Kitamura K,Asada Y

更新日期：2014-01-01 00:00:00

abstract：AIMS:Statins not only reduce low-density lipoprotein (LDL) cholesterol, but also prevent the progression of kidney dysfunction. Ezetimibe, a cholesterol-absorption inhibitor, also lowers LDL cholesterol levels when added to statins; however, the effect of add-on ezetimibe on kidney function has had conflicting results....

journal_title：Journal of atherosclerosis and thrombosis

authors： Kinouchi K,Ichihara A,Bokuda K,Morimoto S,Itoh H

更新日期：2013-01-01 00:00:00

abstract：:A number of effective drugs have been developed through animal experiments, contributing to the health of many patients. In particular, the WHHL rabbit family (WHHL rabbits and its advanced strains (coronary atherosclerosis-prone WHHL-CA rabbits and myocardial infarction-prone WHHLMI rabbits) developed at Kobe Univers...

journal_title：Journal of atherosclerosis and thrombosis

authors： Shiomi M

更新日期：2020-02-01 00:00:00

abstract：AIM:Evidence is lacking about whether urinary stones are associated with the subsequent risk of cardiovascular diseases. Herein, we investigated the association between history of urinary stones and the risk of coronary heart disease (CHD) and stroke among middle-aged Japanese. METHODS:This cohort study included 89,03...

journal_title：Journal of atherosclerosis and thrombosis

authors： Arafa A,Eshak ES,Iso H,Shirai K,Muraki I,Sawada N,Tsugane S,JPHC Study Group.

更新日期：2020-11-01 00:00:00

abstract：AIM:Nephrotic syndrome (NS) is associated with an increased rate of cardiovascular events. The YKL-40 level is associated with atherosclerosis, endothelial dysfunction and proteinuria in renal and non-renal populations. The aim of this study was to investigate the relationships between the YKL-40 level and both vascula...

journal_title：Journal of atherosclerosis and thrombosis

authors： Kocyigit I,Gungor O,Dogan E,Karadavut S,Karakukcu C,Eroglu E,Orscelik O,Unal A,Dogan A,Sipahioglu MH,Tokgoz B,Oymak O

更新日期：2015-01-01 00:00:00

abstract：AIM:Central pulse pressure and measures of arterial stiffness (augmentation index (AIx) and aortic pulse wave velocity (PWV)) predict morbidity and mortality in patients with stage 2-4 chronic kidney disease (CKD). Although statin therapy may be of vascular benefit in patients with CKD, the long-term effect of statins ...

journal_title：Journal of atherosclerosis and thrombosis

authors： Fassett RG,Robertson IK,Ball MJ,Geraghty DP,Sharman JE,Coombes JS

更新日期：2010-03-31 00:00:00

abstract：:Generally, it is considered that visceral fat brings insulin resistance and hyper-insulinemia, in the mechanisms of metabolic syndromes. However, whether hyperinsulinemia brings about accumulation of visceral fat is not clear. We followed a case of insulinoma that caused primary hyperinsulinemia, and measured the chan...

journal_title：Journal of atherosclerosis and thrombosis

authors： Saiki A,Miyashita Y,Wakabayashi M,Kameda N,Shirai K

更新日期：2004-01-01 00:00:00

abstract：:Recent findings suggest that the oxidative modification of low-density lipoproteins (LDL) and an increase in triglyceride-rich lipoprotein particles including chylomicron remnants contribute to the progression of atherosclerosis, as does the inflammatory response. We therefore examined whether and how these lipoprotei...

journal_title：Journal of atherosclerosis and thrombosis

authors： Okumura T,Fujioka Y,Morimoto S,Masai M,Sakoda T,Tsujino T,Kashiwamura S,Okamura H,Ohyanagi M

更新日期：2006-02-01 00:00:00

abstract：:The aim was to give on overview of the profile of cardiovascular disease, vascular pathology and the relationships between lifestyle and cardiovascular disease in Japanese. Compared with the United States and Europe, the higher mortality from stroke and lower mortality from coronary heart disease constitute a unique c...

journal_title：Journal of atherosclerosis and thrombosis

authors： Iso H

更新日期：2011-01-01 00:00:00

abstract：AIM:The Framingham risk score (FRS) is one of the standard tools used to predict the incidence of coronary heart disease (CHD). No previous study has investigated its efficacy for a Japanese population cohort. The purpose of this study was to develop new coronary prediction algorithms for the Japanese population in the...

journal_title：Journal of atherosclerosis and thrombosis

authors： Nishimura K,Okamura T,Watanabe M,Nakai M,Takegami M,Higashiyama A,Kokubo Y,Okayama A,Miyamoto Y

更新日期：2014-01-01 00:00:00

abstract：AIM:In animals, dietary energy restriction is reported to increase longevity, whereas in humans, all cohort studies from Western countries have not shown an association between the low energy intake and longevity. We examined the association between total energy intake and longevity in Japan where dietary pattern is di...

journal_title：Journal of atherosclerosis and thrombosis

authors： Nagai M,Ohkubo T,Miura K,Fujiyoshi A,Okuda N,Hayakawa T,Yoshita K,Arai Y,Nakagawa H,Nakamura K,Miyagawa N,Takashima N,Kadota A,Murakami Y,Nakamura Y,Abbott RD,Okamura T,Okayama A,Ueshima H,NIPPON DATA80 Research Gro

更新日期：2016-01-01 00:00:00

abstract：:Although the human liver comprises approximately 2.8% of the body weight, it plays a central role in the control of energy metabolism. While the biochemistry of energy substrates such as glucose, fatty acids, and ketone bodies in the liver is well understood, many aspects of the overall control system for hepatic meta...

journal_title：Journal of atherosclerosis and thrombosis

authors： Yahagi N

更新日期：2017-01-01 00:00:00