当前位置： SCI文献检索 > Journal of Atherosclerosis and Thrombosis期刊下所有文献 > Vascular complications and coagulation-related changes in the perioperative period in Japanese patients undergoing non-cardiac surgery.

Vascular complications and coagulation-related changes in the perioperative period in Japanese patients undergoing non-cardiac surgery.

Abstract：

AIM:To properly assess the guidance for perioperative management, we undertook a clinical epidemiology study with the primary aim of evaluating the incidence of perioperative vascular complications and their associated factors in a cohort of Japanese patients who underwent non-cardiac surgery in a tertiary medical care center. METHODS:This observational study comprised two parts. In the first part, thrombotic and bleeding events and their risk factors in the perioperative period were evaluated in a total of 2,654 consecutive patients. In the second part, perioperative changes in coagulation-related factors, including the thrombin-antithrombin complex(TAT) and platelet aggregation activity, were serially characterized in 82 individuals randomly chosen from the consecutive patients. RESULTS:The incidence of perioperative vascular complications was as follows: 1.0% for major bleeding, 0.21% for stroke and 0.21% for venous thromboembolism. No episodes of symptomatic myocardial infarction were identified in the studied population. Perioperative changes in coagulation-related factors were found to be complex and correlated in the mixed direction of pro- and anticoagulation. The TAT values showed prolonged(across postoperative days 1-5) and prominent(>116% increase) perioperative activation of coagulation, whereas global coagulation parameters, such as the prothrombin time, showed a tendency of anticoagulation in the immediate postoperative period. CONCLUSIONS:Our data confirm the relatively low incidence of perioperative vascular complications in the general Japanese non-cardiac surgical population. Given the delicate balance between thrombotic and bleeding events, it is important to comprehensively understand the associations between the patient's baseline risk factors and vascular complications for effective clinical management.

journal_name

J Atheroscler Thromb

journal_title

Journal of atherosclerosis and thrombosis

authors

Aoyama-Mani C,Kawachi S,Ogawa Y,Kato N

doi

10.5551/jat.21139

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

414-34

issue

eissn

1340-3478

issn

1880-3873

pii

DN/JST.JSTAGE/jat/21139

journal_volume

pub_type

杂志文章

在线工具

Vascular complications and coagulation-related changes in the perioperative period in Japanese patients undergoing non-cardiac surgery.