Abstract:
AIM:Moderate alcohol consumption appears to confer some protection against coronary heart disease, which is related to an increase in high-density lipoprotein cholesterol (HDL-C). The genotype of aldehyde dehydrogenase 2 (ALDH2) is closely related to alcohol metabolism but a relationship between ALDH2 genotypes and HDL-C levels has not been proven. We undertook a large-scale correlation study between HDL-C levels and ALDH2 genotype among Japanese non-drinkers to investigate the possibility that HDL-C levels could be associated with ALDH2 genotype. METHODS:We examined a population-based sample of Japanese subjects who do not consume alcohol (n=1,736) to investigate the relationship between ALDH2 genotypes and lipid or lipoprotein concentrations in serum. We also investigated whether an association between ALDH2 genotype and HDL-C levels might be found in another Japanese sample. RESULTS:In an independent population of non-drinkers from a different geographical region of Japan, HDL-C levels were associated with the same ALDH2 genotypes. CONCLUSIONS:The results of the present study suggested that genetic variation in the ALDH2 gene can influence HDL-C levels, independent of alcohol consumption.
journal_name
J Atheroscler Thrombjournal_title
Journal of atherosclerosis and thrombosisauthors
Wada M,Daimon M,Emi M,Iijima H,Sato H,Koyano S,Tajima K,Kawanami T,Kurita K,Hunt SC,Hopkins PN,Kubota I,Kawata S,Kato Tdoi
10.5551/jat.e542subject
Has Abstractpub_date
2008-08-01 00:00:00pages
179-84issue
4eissn
1340-3478issn
1880-3873pii
JST.JSTAGE/jat/E542journal_volume
15pub_type
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
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journal_title:Journal of atherosclerosis and thrombosis
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abstract:AIM:Ezetimibe, an inhibitor of cholesterol intestinal absorption, is a lipid lowering agent. However, anti-atherogenic effects of ezetimibe have not been fully elucidated. Therefore, the objective in this study was to clarify the vascular protective effects of ezetimibe in patients with hypercholesterolemia. METHODS:E...
journal_title:Journal of atherosclerosis and thrombosis
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pub_type: 临床试验,杂志文章
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