PCSK9 and Atherosclerosis - Lipids and Beyond.

Abstract:

:Even though it is only a little over a decade from the discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9) as a plasma protein that associates with both high and low cholesterol syndromes, a rich body of knowledge has developed, and drugs inhibiting this target have been approved in many markets. While the majority of research in recent years has focused on the impact of therapeutic antagonism of this molecule, important lines of investigation have emerged characterizing its unique physiology as it relates to cholesterol metabolism and atherosclerosis. The PCSK9 story is unfolding rapidly but is far from complete. One chapter that is of particular interest is the possible direct link between PCSK9 and atherosclerosis. This review specifically examines this relationship drawing from data produced from experimental models of plaque biology and inflammation, atherosclerosis imaging studies, and observational epidemiology.

journal_name

J Atheroscler Thromb

authors

Shapiro MD,Fazio S

doi

10.5551/jat.RV17003

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

462-472

issue

5

eissn

1340-3478

issn

1880-3873

journal_volume

24

pub_type

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