Atrial fibrillation linked to vascular access thrombosis in chronic hemodialysis patients.


AIM:Atrial fibrillation (AF) is characterized by the development of thromboembolic events and is more prevalent among end-stage renal disease patients than in the general population. Vascular access thrombosis (VAT) is a major morbidity in chronic hemodialysis (HD) patients; however, the association between AF and VAT is unknown. METHODS:We retrospectively reviewed chronic HD patients with functional vascular access between 1997 and 2006. The association between AF and the development of VAT was analyzed using Kaplan-Meier analysis and multivariate Cox proportional hazards regression. RESULTS:A total of 568 chronic HD patients, including 55 (9.7%) patients with AF, were reviewed and 154 (27.1%) patients developed at least one episode of VAT. Patients with AF had worse VAT-free survival than patients without AF (p< 0.001). In Cox regression, age, type of vascular access, atrial fibrillation, diabetes, hypertension, and C-reactive protein were independently linked to the development of VAT ( p= 0.049, < 0.001, < 0.001, 0.001, 0.028 and 0.045). The hazard ratios were 2.1 (95% CI: 1.00-1.03) for arteriovenous graft, 2.47 (95% CI: 1.66-3.69) for AF, 1.72 (95% CI: 1.25-2.39) for diabetes and 1.09 (95% CI: 1.00-1.18) for serum C-reactive protein (every 1 mg/dL increase), respectively. CONCLUSION:Atrial fibrillaiton is linked to the development of vascular access thrombosis in chronic hemodialysis patients and is independent of traditional VAT risk factors.


J Atheroscler Thromb


Chou CY,Chen JY,Liu JH,Liu YL,Lin HH,Yang YF,Wang SM,Kuo HL,Huang CC




Has Abstract


2011-01-01 00:00:00














  • Effects of pitavastatin (LIVALO tablet) on the estimated glomerular filtration rate (eGFR) in hypercholesterolemic patients with chronic kidney disease. Sub-analysis of the LIVALO Effectiveness and Safety (LIVES) Study.

    abstract:AIM:In addition to the risk of progression to end-stage renal disease (ESRD), chronic kidney disease (CKD) is also known to be associated with an elevated risk of cardiovascular disease (CVD). Statins may improve renal function in CKD patients. METHODS:The database of the LIVALO Effectiveness and Safety (LIVES) Study,...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Kimura K,Shimano H,Yokote K,Urashima M,Teramoto T

    更新日期:2010-06-30 00:00:00

  • Relationship between high-density lipoprotein-cholesterol and malondialdehyde-modified low-density lipoprotein concentrations.

    abstract::Several reports have suggested that HDL has anti-oxidative actions. We investigated the relationship between HDL-cholesterol (HDL-C) and malondialdehyde-modified LDL (MDA-LDL) concentrations using enzyme linked immunosolvent assay. We divided our study subjects into four groups on the basis of concentrations of trigly...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Kondo A,Li J,Manabe M,Saito K,Kanno T,Maekawa M

    更新日期:2003-01-01 00:00:00

  • Awareness and Prophylaxis of Venous Thromboembolism in Patients with COVID-19: A National Cross-Sectional Survey in Epidemic Era.

    abstract:AIM:Patients with acute infectious diseases are at an increased risk of venous thromboembolism (VTE). Clinicians should be aware of the VTE risk in patients with COVID-19, many of whom present with severe coagulation disorders. METHOD:We used an online platform to conduct a cross-sectional questionnaire survey among d...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Zhang Z,Xi L,Zhang S,Zhang Y,Pang W,Wang Y,Li C,Zhai Z,Wang C

    更新日期:2020-10-01 00:00:00

  • Effects of pitavastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, on cardio-ankle vascular index in type 2 diabetic patients.

    abstract:AIM:A novel device has been developed for measuring the cardio-ankle vascular index (CAVI) as an indicator of arterial stiffness. In this study, we evaluated the effect of pitavastatin on CAVI in type 2 diabetic patients. METHODS:Forty-five type 2 diabetes mellitus patients with low-density lipoprotein cholesterolemia...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,随机对照试验


    authors: Miyashita Y,Endo K,Saiki A,Ban N,Yamaguchi T,Kawana H,Nagayama D,Ohira M,Oyama T,Shirai K

    更新日期:2009-10-01 00:00:00

  • The potential role of macrophage migration inhibitory factor on the migration of vascular smooth muscle cells.

    abstract:AIM:Macrophage migration inhibitory factor (MIF) is known as a pro-inflammatory cytokine that regulates a broad spectrum of inflammatory reactions. MIF is expressed in vascular smooth muscle cells (VSMCs), and inhibition of the progression of atherosclerosis was observed in MIF-deficient atherosclerotic mice. However, ...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Okamoto T,Atsumi T,Shimizu C,Yoshioka N,Koike T

    更新日期:2008-02-01 00:00:00

  • Intracoronary infusion of mononuclear bone marrow-derived stem cells is associated with a lower plaque burden after four years.

    abstract:AIM:To assess the long-term effects of intracoronary stem cell (SC) infusion following acute myocardial infarction (AMI) on the local atherosclerotic process at the site of infusion after four years of follow-up. METHODS:We evaluated 18 post-AMI patients. Group 1 consisted of nine patients given an intracoronary injec...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Benedek I,Bucur O,Benedek T

    更新日期:2014-01-01 00:00:00

  • Ten-year evaluation of homogeneous low-density lipoprotein cholesterol methods developed by Japanese manufacturers. Application of the Centers for Disease Control and Prevention/Cholesterol Reference Method Laboratory Network lipid standardization protoco

    abstract:AIM:The risk index for atherosclerotic cardiovascular diseases in the Japanese metabolic syndrome-focused health checkup program was changed from total cholesterol (TC) to low-density lipoprotein cholesterol (LDL-C). We discuss the validity of this change with respect to standardization. METHODS:The beta-quantificatio...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Nakamura M,Koyama I,Iso H,Sato S,Okazaki M,Kayamori Y,Kiyama M,Kitamura A,Shimamoto T,Ishikawa Y

    更新日期:2010-12-26 00:00:00

  • Five-Year Patency and its Predictors after Endovascular Therapy for Aortoiliac Occlusive Disease.

    abstract:AIM:Although current guidelines recommend surgical revascularization as the first-line therapy for chronic total occlusion of the abdominal aorta (Leriche syndrome), endovascular therapy (EVT) has been increasingly utilized because of the development of new technologies and techniques. EVT has demonstrated durable midt...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,多中心研究


    authors: Nanto K,Iida O,Fujihara M,Yokoi Y,Tomoi Y,Soga Y,Fujita M,Masuda M,Okamoto S,Ishihara T,Kanda T,Tsujimura T,Matsuda Y,Okuno S,Mano T

    更新日期:2019-11-01 00:00:00

  • Association of cardiomegaly with coronary artery histopathology and its relationship to atheroma.

    abstract:AIMS:Hypertrophied hearts at autopsy often display excessive coronary artery atherosclerosis, but the histopathology of coronary arteries in hearts with and without cardiomegaly has rarely been compared. METHODS:In this study, forensic autopsies provided hearts with unexplained enlargement plus comparison specimens. R...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Tracy RE

    更新日期:2011-01-01 00:00:00

  • Associations between plasma C-reactive protein levels and the severities of coronary and aortic atherosclerosis.

    abstract:AIM:Limited correlations between C-reactive protein (CRP) and coronary artery disease (CAD) have been reported. Recently, MRI became a useful tool for non-invasively evaluating atherosclerotic plaques in thoracic and abdominal aortas. METHODS:To elucidate the associations between plasma CRP levels and the severities o...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Momiyama Y,Ohmori R,Fayad ZA,Kihara T,Tanaka N,Kato R,Taniguchi H,Nagata M,Nakamura H,Ohsuzu F

    更新日期:2010-05-01 00:00:00

  • The History of the WHHL Rabbit, an Animal Model of Familial Hypercholesterolemia (II) - Contribution to the Development and Validation of the Therapeutics for Hypercholesterolemia and Atherosclerosis.

    abstract::A number of effective drugs have been developed through animal experiments, contributing to the health of many patients. In particular, the WHHL rabbit family (WHHL rabbits and its advanced strains (coronary atherosclerosis-prone WHHL-CA rabbits and myocardial infarction-prone WHHLMI rabbits) developed at Kobe Univers...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 历史文章,杂志文章


    authors: Shiomi M

    更新日期:2020-02-01 00:00:00

  • Development and Validation of a Risk Prediction Model for Atherosclerotic Cardiovascular Disease in Japanese Adults: The Hisayama Study.

    abstract:AIM:To develop and validate a new risk prediction model for predicting the 10-year risk of atherosclerotic cardiovascular disease (ASCVD) in Japanese adults. METHODS:A total of 2,454 participants aged 40-84 years without a history of cardiovascular disease (CVD) were prospectively followed up for 24 years. An incident...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Honda T,Chen S,Hata J,Yoshida D,Hirakawa Y,Furuta Y,Shibata M,Sakata S,Kitazono T,Ninomiya T

    更新日期:2021-01-22 00:00:00

  • Advanced endothelial dysfunction in diabetic patients with multiple risk factors; importance of insulin resistance.

    abstract:AIM:Endothelial dysfunction is considered an early event in the development of atherosclerosis. The present study was undertaken to determine whether the accumulation of cardiovascular risk factors and insulin resistance are associated with endothelial function in diabetic patients. METHODS:101 patients with type 2 di...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Tsuchiya K,Nakayama C,Iwashima F,Sakai H,Izumiyama H,Doi M,Hirata Y

    更新日期:2007-12-01 00:00:00

  • Hormones and arterial stiffness in patients with chronic kidney disease.

    abstract::Cardiovascular disease constitutes the major cause of mortality in patients with chronic kidney disease. Arterial stiffness is an important contributor to the occurrence and progression of cardiovascular disease. Various risk factors, including altered hormone levels, have been suggested to be associated with arterial...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,评审


    authors: Gungor O,Kircelli F,Voroneanu L,Covic A,Ok E

    更新日期:2013-01-01 00:00:00

  • Exposure to particulate matter and long-term risk of cardiovascular mortality in Japan: NIPPON DATA80.

    abstract:AIM:It remains uncertain whether chronic exposure to particulate air pollution is associated with increased mortality in Japan because Japan has a different distribution pattern of cardiovascular disease and its risk factors compared to Western countries. We investigated the association between long-term exposure to pa...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,随机对照试验


    authors: Ueda K,Nagasawa SY,Nitta H,Miura K,Ueshima H,NIPPON DATA80 Research Group.

    更新日期:2012-01-01 00:00:00

  • CD40 ligand and MCP-1 as predictors of cardiovascular events in diabetic patients with stroke.

    abstract:AIM:Up-regulation of soluble CD40 ligand (sCD40L) and of monocyte chemoattractant protein-1 (MCP-1) has been found in diabetes and in patients with acute cerebral ischemia. We asked whether (i) the two molecules are similarly upregulated among non-lacunar and lacunar diabetic strokes and (ii) sCD40L and/or MCP-1 predic...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Davì G,Tuttolomondo A,Santilli F,Basili S,Ferrante E,Di Raimondo D,Pinto A,Licata G

    更新日期:2009-01-01 00:00:00

  • Association of Total Energy Intake with 29-Year Mortality in the Japanese: NIPPON DATA80.

    abstract:AIM:In animals, dietary energy restriction is reported to increase longevity, whereas in humans, all cohort studies from Western countries have not shown an association between the low energy intake and longevity. We examined the association between total energy intake and longevity in Japan where dietary pattern is di...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Nagai M,Ohkubo T,Miura K,Fujiyoshi A,Okuda N,Hayakawa T,Yoshita K,Arai Y,Nakagawa H,Nakamura K,Miyagawa N,Takashima N,Kadota A,Murakami Y,Nakamura Y,Abbott RD,Okamura T,Okayama A,Ueshima H,NIPPON DATA80 Research Gro

    更新日期:2016-01-01 00:00:00

  • Association between the CHADS2 score and an ankle-brachial index of <0.9 in patients without atrial fibrillation.

    abstract:AIM:The ankle-brachial index(ABI) is an easy-to-use, non-invasive and reliable diagnostic tool for assessing peripheral arterial occlusive disease(PAOD). The CHADS2(congestive heart failure, hypertension, age ≧75 years, diabetes, prior stroke) score is a simple and popular clinical parameter that is used to assess the ...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Hsu PC,Lin TH,Lee WH,Chu CY,Chiu CA,Lee HH,Su HM,Voon WC,Lai WT,Sheu SH

    更新日期:2014-01-01 00:00:00

  • Expression of matrix metalloproteinase 3 in experimental atherosclerotic plaques.

    abstract::In atherosclerotic lesions, matrix metalloproteinases produced by foam cells (macrophages) are thought to increase plaque instability, promote plaque rupture, by degradating extracellular matrix. To investigate the relationship between the expression of these proteinases and the histologic appearance of atheromas, imm...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Okamoto Y,Satomura K,Ohsuzu F,Nakamura H,Takeuchi K,Yoshioka M

    更新日期:2001-01-01 00:00:00

  • Effects of calorie-restricted low-carbohydrate diet on glucose and lipid metabolism in Otsuka Long Evans Tokushima Fatty rats.

    abstract:AIM:We investigated the effects of a calorie-restricted low-carbohydrate diet on glucose and lipid metabolism, and body fat distribution, especially on the secretion of leptin and lipoprotein lipase from adipose tissue in Otsuka Long Evans Tokushima Fatty (OLETF) rats. METHODS:Forty-three week-old male OLETF rats were...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Koide N,Oyama T,Miyashita Y,Shirai K

    更新日期:2007-10-01 00:00:00

  • Platelet function measured using a whole blood aggregometer can predict bleeding events.

    abstract:AIM:We hypothesized that excessive suppression of platelet function due to antiplatelet therapy can increase the incidence of bleeding complications. The aim of the present study was to find whether we could predict bleeding events by measuring platelet function. METHODS:We enrolled 743 subjects whose platelet functio...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Sairaku A,Nakano Y,Eno S,Hondo T,Matsuda K,Kisaka T,Kihara Y

    更新日期:2011-01-01 00:00:00

  • Mild Hyperbaric Oxygen Inhibits Growth-related Decrease in Muscle Oxidative Capacity of Rats with Metabolic Syndrome.

    abstract:AIM:We examined the effects of mild hyperbaric oxygen on the properties of the soleus muscle in rats with metabolic syndrome. METHODS:Five-week-old metabolic syndrome (SHR/NDmcr-cp, cp/cp) rats were divided into normobaric (CP) and mild hyperbaric oxygen (CP-H) groups (n=5/group). In addition, 5-week-old Wistar rats w...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Takemura A,Ishihara A

    更新日期:2017-01-01 00:00:00

  • Completeness of carotid intima media thickness measurements depends on body composition: the RADIANCE 1 and 2 trials.

    abstract:AIM:Ultrasound protocols to measure carotid intima media thickness (CIMT) differ considerably with regard to the inclusion of the number of carotid segments and angles used. Detailed information on the completeness of CIMT information is often lacking in published reports, and at most, overall percentages are presented...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Dogan S,Duivenvoorden R,Grobbee DE,Kastelein JJ,Shear CL,Evans GW,Visseren FL,Bots ML,Radiance 1 and 2 Study Groups.

    更新日期:2010-05-01 00:00:00

  • Clinical impact of the leptin to soluble leptin receptor ratio on subclinical carotid atherosclerosis in patients with type 2 diabetes.

    abstract:AIM:The adipocyte-derived hormone leptin plays a key role in the regulation of food intake and energy expenditure. Recent studies have suggested that leptin is also involved in the pathogenesis of obesity-associated atherosclerosis and cardiovascular disease. In this study, we investigated the associations of leptin an...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Yamazaki Y,Emoto M,Morioka T,Kawano N,Lee E,Urata H,Tsuchikura S,Motoyama K,Mori K,Fukumoto S,Shoji T,Nishizawa Y,Inaba M

    更新日期:2013-01-01 00:00:00

  • Predicting coronary heart disease using risk factor categories for a Japanese urban population, and comparison with the framingham risk score: the suita study.

    abstract:AIM:The Framingham risk score (FRS) is one of the standard tools used to predict the incidence of coronary heart disease (CHD). No previous study has investigated its efficacy for a Japanese population cohort. The purpose of this study was to develop new coronary prediction algorithms for the Japanese population in the...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,随机对照试验


    authors: Nishimura K,Okamura T,Watanabe M,Nakai M,Takegami M,Higashiyama A,Kokubo Y,Okayama A,Miyamoto Y

    更新日期:2014-01-01 00:00:00

  • PCSK9 and Atherosclerosis - Lipids and Beyond.

    abstract::Even though it is only a little over a decade from the discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9) as a plasma protein that associates with both high and low cholesterol syndromes, a rich body of knowledge has developed, and drugs inhibiting this target have been approved in many markets. While ...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,评审


    authors: Shapiro MD,Fazio S

    更新日期:2017-05-01 00:00:00

  • Clinical Effects of Planned Endovascular Therapy for Critical Limb Ischemia Patients with Tissue Loss.

    abstract:AIM:The aim of this study was to investigate the clinical effect of planned endovascular therapy (EVT) for critical limb ischemia (CLI) patients with tissue loss. Although several rounds of EVT for CLI patients are required for complete wound healing, time required for complete wound healing depends on the wound severi...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Fukunaga M,Kawasaki D,Nishimura M,Yamagami M,Fujiwara R,Nakata T

    更新日期:2019-03-01 00:00:00

  • Ezetimibe monotherapy ameliorates vascular function in patients with hypercholesterolemia through decreasing oxidative stress.

    abstract:AIM:Ezetimibe, an inhibitor of cholesterol intestinal absorption, is a lipid lowering agent. However, anti-atherogenic effects of ezetimibe have not been fully elucidated. Therefore, the objective in this study was to clarify the vascular protective effects of ezetimibe in patients with hypercholesterolemia. METHODS:E...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Kurobe H,Aihara K,Higashida M,Hirata Y,Nishiya M,Matsuoka Y,Kanbara T,Nakayama T,Kinoshita H,Sugano M,Fujimoto E,Kurobe A,Sugasawa N,Kitaichi T,Akaike M,Sata M,Matsumoto T,Kitagawa T

    更新日期:2011-01-01 00:00:00

  • Exposure to Parental Smoking in Childhood is Associated with High C-Reactive Protein in Adulthood: The Cardiovascular Risk in Young Finns Study.

    abstract:AIM:Children exposed to parental smoking are at increased long-term risk of subclinical atherosclerosis in adulthood. However, it has not been quantified if exposure to parental smoking in childhood is associated with adult systemic inflammation. This study aimed to determine if childhood exposure to parental smoking w...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章


    authors: Wang D,Juonala M,Viikari JSA,Wu F,Hutri-Kähönen N,Raitakari OT,Magnussen CG

    更新日期:2017-12-01 00:00:00

  • Role of molecular regulation in vascular calcification.

    abstract::Calcium deposits account for most of the dry weight of atherosclerotic lesions. Previously considered uncommon, vascular calcification is now known to be present in 80% of significant lesions and in at least 90% of patients with coronary artery disease. Previously considered a passive process, it is increasingly recog...

    journal_title:Journal of atherosclerosis and thrombosis

    pub_type: 杂志文章,评审


    authors: Parhami F,Boström K,Watson K,Demer LL

    更新日期:1996-01-01 00:00:00