Abstract:
AIM:To assess the long-term effects of intracoronary stem cell (SC) infusion following acute myocardial infarction (AMI) on the local atherosclerotic process at the site of infusion after four years of follow-up. METHODS:We evaluated 18 post-AMI patients. Group 1 consisted of nine patients given an intracoronary injection of autologous mononuclear SC, and group 2 consisted of nine patients given a placebo injection. The plaque count, plaque burden (PB) and coronary calcium score (CCS) were assessed using multislice 64 CT angiography of the coronary tree four years after SC injection. RESULTS:The total PB and CCS along the entire coronary segment distal to the site of infusion were significantly lower in the SC group (PB-702 mm(3) vs. 1.465 mm(3), p=0.0006; CCS-295 vs. 796, p< 0.0001).The mean PB per coronary artery was 112.12 mm(3)±16.82 mm(3) for the treated arteries vs. 189.56 mm(3)±20.98 mm(3) for the untreated arteries (p<0.0001), while the mean CCS was 53.12±16.4 vs. 106.43±10.86 (p<0.0001). In the SC group, there were significant differences in the mean PB (87.75 mm(3) vs. 112.12 mm(2), p= 0.005) and mean CCS (36.87 vs. 53.12, p=0.04) between the coronary segment infused with SC and the entire coronary artery. CONCLUSIONS:Multislice CT angiography of atheromatous plaques in the coronary tree four years after SC infusion in post-AMI patients indicates a significantly lower atheromatous plaque burden, as demonstrated by a lower plaque volume and lower CCS at the site of stem cell infusion compared with other coronary territories.
journal_name
J Atheroscler Thrombjournal_title
Journal of atherosclerosis and thrombosisauthors
Benedek I,Bucur O,Benedek Tdoi
10.5551/jat.19745subject
Has Abstractpub_date
2014-01-01 00:00:00pages
217-29issue
3eissn
1340-3478issn
1880-3873pii
DN/JST.JSTAGE/jat/19745journal_volume
21pub_type
杂志文章abstract:AIM:This study was designed to analyze microparticles (MPs) from endothelial cells (EMPs) and immune cells from healthy individuals and paitents with Takayasu arteritis (TA), and any possible relationships between MPs and TA acitivity. METHODS:MPs derived from the plasma of 51 subjects were analyzed, including 32 pati...
journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
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abstract:AIM:Speckle-tracking imaging has been introduced for the precise assessment of vessel mechanics. However, there are no data on the role of this imaging tool in assessing the changes in vasculature with statin therapy, which is known to enhance vascular elasticity. METHODS:This study was a prospective study including 4...
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journal_title:Journal of atherosclerosis and thrombosis
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
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更新日期:2003-01-01 00:00:00
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journal_title:Journal of atherosclerosis and thrombosis
pub_type: 杂志文章
doi:10.5551/jat1994.1.53
更新日期:1994-01-01 00:00:00
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