Abstract：
:Hearts from subjects with different ages have different Ca(2+) signaling. Release of Ca(2+) from intracellular stores in response to an action potential initiates cardiac contraction. Both depolarization-stimulated and spontaneous Ca(2+) releases, Ca(2+) transients and Ca(2+) sparks, demonstrate the main events of excitation-contraction coupling (ECC). Global increase in free Ca(2+) concentration ([Ca(2+)]( i )) consists of summation of Ca(2+) release events in cardiomyocytes. Since the Ca(2+) flux induced by Ca(2+) sparks reports a summation of ryanodine-sensitive Ca(2+) release channels (RyR2s)'s behavior in a spark cluster, evaluation of the properties of Ca(2+) sparks and Ca(2+) transients may provide insight into the role of RyR2s on altered heart function between 3-month-old (young adult) and 6-month-old (mature adult) rats. Basal [Ca(2+)]( i ) and Ca(2+) sparks frequency were significantly higher in mature adult rats compared to those of young adults. Moreover, amplitudes of Ca(2+) sparks and Ca(2+) transients were significantly smaller in mature adults than those of young adults with longer time courses. A smaller L-type Ca(2+) current density and decreased SR Ca(2+) load was observed in mature adult rats. In addition, RyR2s were markedly hyperphosphorylated, and phosphorylation levels of PKA and CaMKII were higher in heart from mature adults compared to those of young adults, whereas their SERCA protein levels were similar. Our data demonstrate that hearts from rats with different ages have different Ca(2+) signaling including hyperphosphorylation of RyR2s and higher basal [Ca(2+)]( i ) together with increased oxidized protein-thiols in mature adult rats compared to those of young adults, which play important roles in ECC. Finally, we report that ECC efficiency changes with age during maturation, partially related with an increased cellular oxidation level leading to reduced free protein-thiols in cardiomyocytes.
journal_name
J Physiol Biochemjournal_title
Journal of physiology and biochemistryauthors
Kandilci HB,Tuncay E,Zeydanli EN,Sozmen NN,Turan Bdoi
10.1007/s13105-011-0077-3subject
Has Abstractpub_date
2011-09-01 00:00:00pages
317-30issue
3eissn
1138-7548issn
1877-8755journal_volume
67pub_type
杂志文章abstract：:Although pigs are adapted to starch-rich diets and have high turnover rates of glucose, very scarce information is available on the molecular basis of glucose transport. Therefore, the present study attempted a systematic screening for the presence of mRNA of glucose transport proteins in main organs of glucose absorp...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03180578
更新日期：2009-09-01 00:00:00
abstract：:Paeonol (Pae) is the main active ingredient from the root bark of Paeonia moutan and the grass of Radix Cynanchi Paniculati. Numerous reports indicate that Pae effectively inhibits several types of cancer lines. In this study, we report that Pae hinders prostate cancer growth both in vivo and in vitro. Human prostate ...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-016-0537-x
更新日期：2017-05-01 00:00:00
abstract：:There have been numerous reports that infusion of either natural bile or bile salts into the duodenum evokes a rapid increase in pancreatic secretion through the release of the hormone secretin from the duodenal mucosa. We have extended this observation by the demonstration of an additional late increase in secretion ...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-012-0165-z
更新日期：2012-12-01 00:00:00
abstract：:The purpose of this study was to apply the new approach for Metabolic Individual Risk-factor And Clustering Estimation (MIRACLE) score in a group of Spanish obese children and adolescents and to describe its relationship with other metabolic risk factors. 153 children with simple obesity were studied: 79 males and 74 ...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03165766
更新日期：2007-12-01 00:00:00
abstract：:Vitamin A or retinol plays a major role in the regulation of cellular homeostasis. Retinyl palmitate remains the main chemical form of vitamin A storage and is mainly located in hepatic stellate cells (HSCs) in lipid droplets resembling those found in adipose cells. White adipose tissue (WAT), is essentially involved ...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
doi：10.1007/s13105-011-0101-7
更新日期：2011-09-01 00:00:00
abstract：:Previous studies with different results have suggested that total and bioavailable testosterone levels are modified by physical exercise. Such changes may be related to modifications in cortisol levels and could be reflected in some urine androgens. To determine how weight lifting training may affect serum and urinary...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-010-0018-6
更新日期：2010-06-01 00:00:00
abstract：:To investigate the effects of pectin on cholesterol metabolism, normal rats were fed for three weeks a diet containing 2.5 or 5 % apple or orange pectin, or without pectin (control). Cholesterol concentrations were determined in faeces after 1, 2 and 3 weeks of treatment, and in liver and serum at the end of the exper...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：:Low shear stress (LSS) occurs in areas where atherosclerosis is prevalent. Many studies have revealed that signal transducer and activator of transcription 1 (STAT1) plays a significant role in cardiovascular disease. Nonetheless, the mechanism underlying the connection between STAT1 and LSS is not fully understood. T...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-020-00729-1
更新日期：2020-02-01 00:00:00
abstract：:A large number of researches have led to a substantial growth of knowledge about exercise and oxidative stress. Initial investigations reported that physical exercise generates free radical-mediated damages to cells; however, in recent years, studies have shown that regular exercise can upregulate endogenous antioxida...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
doi：10.1007/s13105-018-0633-1
更新日期：2018-08-01 00:00:00
abstract：:The present review aims to illustrate current knowledge about the efficacy of omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) in treating/preventing several metabolic pathologies. We reviewed systematically the published evidence on the effectiveness of n-3 LC-PUFAs fish consumption or n-3 LC-PUFAs suppl...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
doi：10.1007/s13105-013-0265-4
更新日期：2013-09-01 00:00:00
abstract：:O-Acetylserine(thiol)lyase (OASTL) enzyme catalyzes the cysteine biosynthesis in photosynthetic organisms. In mature Arabidopsis thaliana the highest activity level is observed in non-photosynthetic tissues like roots, that also show significant amount of protein detected by Western blot analysis. By means of specific...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:Several meta-analyses describing the effect of n-3 polyunsaturated fatty acids on the survival rate of the victims of an acute coronary event do not clearly support a beneficial impact of these fatty acids. Yet, animal studies consistently show n-3 PUFA-induced protection against ischemia-reperfusion-induced myocardia...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
doi：10.1007/s13105-019-00670-y
更新日期：2019-08-01 00:00:00
abstract：:The number of patients that suffer some type of spinal cord lesion in recent years are high and have increased because of factors such as traffic accidents. Although their life expectancy has increased, cardiovascular illnesses is one of the main causes of morbidity and mortality. Since the degree of physical fitness ...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03179863
更新日期：2003-03-01 00:00:00
abstract：:Diabetes is a risk factor for cardiovascular disease that has a multifactorial etiology, with oxidative stress as an important component. Our previous observation of a significant diabetes-related increase in rat cardiac catalase (CAT) activity suggested that CAT could play a major role in delaying the development of ...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-014-0363-y
更新日期：2014-12-01 00:00:00
abstract：:Opioid receptors play an important role in modulation of hyperalgesia in inflamed tissues, but chronic morphine application induces such side effects as tolerance. There is near communications between cytokines and mu opioid receptor expression. This study was aimed to assess the role of serum IL-10 in morphine tolera...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-014-0330-7
更新日期：2014-06-01 00:00:00
abstract：:Cells are armed with a vast repertoire of antioxidant defence mechanisms to prevent the accumulation of oxidative damage. The cellular adaptive response is an important antioxidant mechanism against physiological and pathophysiological oxidative alterations in a cell's microenvironment. The aim of this paper was to st...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03165787
更新日期：2007-09-01 00:00:00
abstract：:Transcriptional factors are easily susceptible to any stimuli, including exercise. Exercise can significantly influence PGC-1 α and AMPK-SIRT1 pathway, as it is involved in the regulation of energy metabolism and mitochondrial biogenesis. Exercise is a major energy deprivation process by which many of transcription fa...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
doi：10.1007/s13105-017-0576-y
更新日期：2017-11-01 00:00:00
abstract：:The weight loss observed in consumers of extracts of Citrus aurantium (bitter orange) has been tentatively attributed to the lipolytic and thermogenic effects of the alkaloids abundant in the unripe fruit. Synephrine, octopamine, tyramine, and other alkaloids have been repeatedly identified and quantified in Citrus me...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-011-0078-2
更新日期：2011-09-01 00:00:00
abstract：:Thrombospondin 1 (TSP-1), an antiangiogenic factor and transforming growth factor (TGF)-β activity regulator, has been recently recognized as an adipokine that correlates with obesity, inflammation and insulin resistance processes. In the present study, epididymal adipocytes of rats that were fed a chow or a high-fat ...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-011-0081-7
更新日期：2011-09-01 00:00:00
abstract：:Iron is a trace element and a structural part of antioxidant enzymes, and its requirements vary according to age and gender. We hypothesized that iron deficiency (ID) leads to an increase in free radicals which mainly affect the brain, and the severity of damage would therefore be dependent on age and gender. Two grou...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-016-0529-x
更新日期：2017-02-01 00:00:00
abstract：:In traditional herbal medicine, Rock Tea (Jasonia glutinosa) is known for its prophylactic and therapeutic value in various disorders including arterial hypertension. However, the mechanism by which Rock Tea exerts blood pressure-lowering actions has not been elucidated yet. Our aim was to demonstrate vasorelaxing eff...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-015-0442-8
更新日期：2015-12-01 00:00:00
abstract：:In the absence of progesterone (P), the anti-P at the receptor RU486 reduces basal and GnRH-stimulated LH secretion both in vivo and in vitro, demonstrating the existence of a ligand-independent activation of progesterone receptor (LIAPR). The aim of the present study was to determine which component of the intracellu...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03165804
更新日期：2006-03-01 00:00:00
abstract：:There are a number of hypothetical explanations for the actions of ethanol on the exocrine pancreas; among them, the cholinergic hypothesis has received special attention. According to this hypothesis, chronic alcohol consumption induces alterations in the control of exocrine pancreatic function resulting in cholinerg...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03179781
更新日期：2000-09-01 00:00:00
abstract：:In response to stress, the hypothalamus releases cortiticotropin releasing hormone (CRH) that travels to the anterior pituitary, where it stimulates the release of adrenocorticotropic hormone (ACTH). ACTH travels to the adrenal cortex, where it stimulates the release of cortisol and other steroids that liberate energy...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
doi：10.1007/s13105-012-0227-2
更新日期：2013-09-01 00:00:00
abstract：:High fat diet (HFD) is a common cause of metabolic syndrome and type 2 diabetes mellitus. Published data showed that HFD and subsequent dyslipidemia are major triggers for oxidative stress. Forty-eight male Sprague-Dawley rats, weighing 170-200 g, were divided into six groups: control, control with vitamin E (100 mg/k...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-013-0250-y
更新日期：2013-12-01 00:00:00
abstract：:Type 2 diabetes (T2D) is a complicated systemic disease, and the exact pathogenetic molecular mechanism is unclear. Distinct histone modifications regulate gene expression in certain diseases, but little is known about histone epigenetics in diabetes. In the current study, C57BL/6 J mice were used to build T2D model, ...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-015-0385-0
更新日期：2015-03-01 00:00:00
abstract：:Isoflavones are a group of natural phytoestrogens including the compound genistein. Health beneficial effects have been attributed to the consumption of this compound, but the fact that it has estrogen-like activity has raised doubts regarding its potential risk in infants, newborns, or in the fetus and placenta durin...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03179062
更新日期：2009-06-01 00:00:00
abstract：:The influence of maternal fat mass and obesity (FTO) gene polymorphism on neonatal insulin sensitivity/resistance biomarkers and lipoprotein profile has not been tested. The study aimed to assess the association between the FTO rs9939609 polymorphism in mother-neonate couples and neonatal anthropometrical measurements...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-016-0467-7
更新日期：2016-06-01 00:00:00
abstract：:We examined the serum concentrations of leptin in a homogeneous group of 52 postmenopausal Mediterranean women, calculating body fat mass distribution by waist-to-hip circumference ratio (WHR) and other anthropometric measurements. Significant correlations were found between leptin and weight (r=0.59), Body Mass Index...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03179888
更新日期：2003-12-01 00:00:00
abstract：:The presence of metabolic syndrome (MS) per se or its separated components in HIV-infected patients contributes to an accelerated aging and increased cardiovascular risk. Gut microbiota (GM) dysbiosis has been linked with chronic inflammation associated with MS in a general non-infected population. However, no studies...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-019-00673-9
更新日期：2019-08-01 00:00:00
